Progenitor cell dynamics in the newt telencephalon during homeostasis and neuronal regeneration

Matthew Kirkham*, L. Shahul Hameed, Daniel A. Berg, Heng Wang, András Simon

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

28 Citations (Scopus)

Abstract

The adult newt brain has a marked neurogenic potential and is highly regenerative. Ventricular, radial glia-like ependymoglia cells give rise to neurons both during normal homeostasis and after injury, but subpopulations among ependymoglia cells have not been defined. We show here that a substantial portion of GFAP+ ependymoglia cells in the proliferative hot spots of the telencephalon has transit-amplifying characteristics. In contrast, proliferating ependymoglia cells, which are scattered along the ventricular wall, have stem cell features in terms of label retention and insensitivity to AraC treatment. Ablation of neurons remodels the proliferation dynamics and leads to de novo formation of regions displaying features of neurogenic niches, such as the appearance of cells with transit-amplifying features and proliferating neuroblasts. The results have implication both for our understanding of the evolutionary diversification of radial glia cells as well as the processes regulating neurogenesis and regeneration in the adult vertebrate brain.

Original languageEnglish
Pages (from-to)507-519
Number of pages13
JournalStem Cell Reports
Volume2
Issue number4
Early online date20 Mar 2014
DOIs
Publication statusPublished - 8 Apr 2014

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