Prognosis in Incident Parkinsonian Cohort: The Pine Study

Carl Counsell, Shona Fielding, Angus Macleod, Hazel Forbes, Clare Harris

Research output: Contribution to journalAbstract

Abstract


Background There are few prognostic data from community-based incident cohorts of people with Parkinson's disease (PD) or atypical parkinsonism.


Methods An incident cohort of people with degenerative or vascular parkinsonism and age-gender matched controls were followed up annually from diagnosis until death. Participants are seen yearly to gather data on multiple outcomes including survival, disability (dependency on others for activities of daily living) and institutionalisation. Research criteria are used to guide the clinical diagnosis. We analysed all-cause mortality, disability and institutionalisation by different diagnostic categories using survival analysis.


Results 361/377 (96%) incident patients (203 PD, 43 DLB, 43 Parkinson's plus, 39 vascular, 33 other; mean age at diagnosis 75 yrs) and 262 controls (mean age 75yrs) were followed up for a median of 5.5yrs. Mortality was higher in patients than controls (adjusted hazards ratio 2.01 for PD, 95% CI 1.30–3.12), especially for atypical parkinsonism (median survival PD 92 months, other disorders 25–39 months). At three years the rates of death or dependency were: controls 21%, PD 47%, atypical parkinsonism 95% whilst institutionalisation rates were: controls 2.5%, PD 7.5%, atypical parkinsonism 31–68%.


Conclusion Incident parkinsonian patients, particularly those with atypical parkinsonism, have significantly higher rates of death, dependency and institutionalisation than controls.
Original languageEnglish
Article numbere4
Number of pages1
JournalJournal of Neurology, Neurosurgery & Psychiatry
Volume85
Issue number10
DOIs
Publication statusPublished - Oct 2014
EventMeeting of the Associatiion-of-British-Neurologists - Cardiff, United Kingdom
Duration: 7 May 20149 May 2014

Cite this

Prognosis in Incident Parkinsonian Cohort : The Pine Study. / Counsell, Carl; Fielding, Shona; Macleod, Angus; Forbes, Hazel; Harris, Clare.

In: Journal of Neurology, Neurosurgery & Psychiatry, Vol. 85, No. 10, e4, 10.2014.

Research output: Contribution to journalAbstract

@article{b46e7092e0684f0ab8d30a379dbf37ad,
title = "Prognosis in Incident Parkinsonian Cohort: The Pine Study",
abstract = "Background There are few prognostic data from community-based incident cohorts of people with Parkinson's disease (PD) or atypical parkinsonism. Methods An incident cohort of people with degenerative or vascular parkinsonism and age-gender matched controls were followed up annually from diagnosis until death. Participants are seen yearly to gather data on multiple outcomes including survival, disability (dependency on others for activities of daily living) and institutionalisation. Research criteria are used to guide the clinical diagnosis. We analysed all-cause mortality, disability and institutionalisation by different diagnostic categories using survival analysis. Results 361/377 (96{\%}) incident patients (203 PD, 43 DLB, 43 Parkinson's plus, 39 vascular, 33 other; mean age at diagnosis 75 yrs) and 262 controls (mean age 75yrs) were followed up for a median of 5.5yrs. Mortality was higher in patients than controls (adjusted hazards ratio 2.01 for PD, 95{\%} CI 1.30–3.12), especially for atypical parkinsonism (median survival PD 92 months, other disorders 25–39 months). At three years the rates of death or dependency were: controls 21{\%}, PD 47{\%}, atypical parkinsonism 95{\%} whilst institutionalisation rates were: controls 2.5{\%}, PD 7.5{\%}, atypical parkinsonism 31–68{\%}. Conclusion Incident parkinsonian patients, particularly those with atypical parkinsonism, have significantly higher rates of death, dependency and institutionalisation than controls.",
author = "Carl Counsell and Shona Fielding and Angus Macleod and Hazel Forbes and Clare Harris",
year = "2014",
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language = "English",
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journal = "Journal of Neurology, Neurosurgery & Psychiatry",
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TY - JOUR

T1 - Prognosis in Incident Parkinsonian Cohort

T2 - The Pine Study

AU - Counsell, Carl

AU - Fielding, Shona

AU - Macleod, Angus

AU - Forbes, Hazel

AU - Harris, Clare

PY - 2014/10

Y1 - 2014/10

N2 - Background There are few prognostic data from community-based incident cohorts of people with Parkinson's disease (PD) or atypical parkinsonism. Methods An incident cohort of people with degenerative or vascular parkinsonism and age-gender matched controls were followed up annually from diagnosis until death. Participants are seen yearly to gather data on multiple outcomes including survival, disability (dependency on others for activities of daily living) and institutionalisation. Research criteria are used to guide the clinical diagnosis. We analysed all-cause mortality, disability and institutionalisation by different diagnostic categories using survival analysis. Results 361/377 (96%) incident patients (203 PD, 43 DLB, 43 Parkinson's plus, 39 vascular, 33 other; mean age at diagnosis 75 yrs) and 262 controls (mean age 75yrs) were followed up for a median of 5.5yrs. Mortality was higher in patients than controls (adjusted hazards ratio 2.01 for PD, 95% CI 1.30–3.12), especially for atypical parkinsonism (median survival PD 92 months, other disorders 25–39 months). At three years the rates of death or dependency were: controls 21%, PD 47%, atypical parkinsonism 95% whilst institutionalisation rates were: controls 2.5%, PD 7.5%, atypical parkinsonism 31–68%. Conclusion Incident parkinsonian patients, particularly those with atypical parkinsonism, have significantly higher rates of death, dependency and institutionalisation than controls.

AB - Background There are few prognostic data from community-based incident cohorts of people with Parkinson's disease (PD) or atypical parkinsonism. Methods An incident cohort of people with degenerative or vascular parkinsonism and age-gender matched controls were followed up annually from diagnosis until death. Participants are seen yearly to gather data on multiple outcomes including survival, disability (dependency on others for activities of daily living) and institutionalisation. Research criteria are used to guide the clinical diagnosis. We analysed all-cause mortality, disability and institutionalisation by different diagnostic categories using survival analysis. Results 361/377 (96%) incident patients (203 PD, 43 DLB, 43 Parkinson's plus, 39 vascular, 33 other; mean age at diagnosis 75 yrs) and 262 controls (mean age 75yrs) were followed up for a median of 5.5yrs. Mortality was higher in patients than controls (adjusted hazards ratio 2.01 for PD, 95% CI 1.30–3.12), especially for atypical parkinsonism (median survival PD 92 months, other disorders 25–39 months). At three years the rates of death or dependency were: controls 21%, PD 47%, atypical parkinsonism 95% whilst institutionalisation rates were: controls 2.5%, PD 7.5%, atypical parkinsonism 31–68%. Conclusion Incident parkinsonian patients, particularly those with atypical parkinsonism, have significantly higher rates of death, dependency and institutionalisation than controls.

U2 - 10.1136/jnnp-2014-309236.198

DO - 10.1136/jnnp-2014-309236.198

M3 - Abstract

VL - 85

JO - Journal of Neurology, Neurosurgery & Psychiatry

JF - Journal of Neurology, Neurosurgery & Psychiatry

SN - 0022-3050

IS - 10

M1 - e4

ER -