Prognosis of multi-lobar pneumonia in community-acquired pneumonia: a systematic review and meta-analysis

Gurdeep Singh Mannu, Yoon Kong Loke, James Peter Curtain, Kelum Nadeesha Pelpola, Phyo Kyaw Myint

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Background
Pneumonia is the leading cause of infection related mortality. Multilobar pneumonia (MLP) may have poorer outcomes and is a constituent of some prognostic indices. Our aim was to systematically-review and meta-analyse the impact of multi-lobar involvement in pneumonia.

Methods
We searched PubMed in June 2012 for studies reporting on the association between MLP and clinical outcomes. Potentially relevant studies were cross checked by two independent reviewers before final inclusion. Odds-ratios (OR) for the association between MLP and mortality, unfavourable outcomes, and poor treatment response were pooled using random effects meta-analysis.

Results
Twenty-two studies were included in this report. There were a total of 11,456 pneumonia patients including 2897 (25.3%) patients with MLP. As there was substantial clinical and statistical heterogeneity in the overall dataset, we limited the main meta-analysis to patients with community-acquired pneumonia (CAP). This showed that MLP was associated with increased mortality, OR 2.57 (95% CI: 1.83–3.61), with no statistical heterogeneity (I2 = 0%). Evidence from other settings suggests that MLP may also be associated with higher likelihood of other poor outcomes such as worsening clinical/radiological status, delayed resolution, and need for mechanical ventilation.

Conclusion
MLP appears to be an independent risk factor for mortality in CAP. It may be possible to improve commonly used prognostic indices in CAP by addition of MLP as a criterion.
Original languageEnglish
Pages (from-to)857-863
Number of pages7
JournalEuropean Journal of Internal Medicine
Volume24
Issue number8
Early online date6 Jun 2013
DOIs
Publication statusPublished - Dec 2013

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Meta-Analysis
Pneumonia
Mortality
Odds Ratio
Artificial Respiration
PubMed

Keywords

  • multilobar pneumonia
  • community-acquired pneumonia
  • prognosis
  • complications
  • outcomes

Cite this

Prognosis of multi-lobar pneumonia in community-acquired pneumonia : a systematic review and meta-analysis. / Mannu, Gurdeep Singh; Loke, Yoon Kong; Curtain, James Peter; Pelpola, Kelum Nadeesha; Myint, Phyo Kyaw.

In: European Journal of Internal Medicine, Vol. 24, No. 8, 12.2013, p. 857-863.

Research output: Contribution to journalArticle

Mannu, Gurdeep Singh ; Loke, Yoon Kong ; Curtain, James Peter ; Pelpola, Kelum Nadeesha ; Myint, Phyo Kyaw. / Prognosis of multi-lobar pneumonia in community-acquired pneumonia : a systematic review and meta-analysis. In: European Journal of Internal Medicine. 2013 ; Vol. 24, No. 8. pp. 857-863.
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abstract = "BackgroundPneumonia is the leading cause of infection related mortality. Multilobar pneumonia (MLP) may have poorer outcomes and is a constituent of some prognostic indices. Our aim was to systematically-review and meta-analyse the impact of multi-lobar involvement in pneumonia.MethodsWe searched PubMed in June 2012 for studies reporting on the association between MLP and clinical outcomes. Potentially relevant studies were cross checked by two independent reviewers before final inclusion. Odds-ratios (OR) for the association between MLP and mortality, unfavourable outcomes, and poor treatment response were pooled using random effects meta-analysis.ResultsTwenty-two studies were included in this report. There were a total of 11,456 pneumonia patients including 2897 (25.3{\%}) patients with MLP. As there was substantial clinical and statistical heterogeneity in the overall dataset, we limited the main meta-analysis to patients with community-acquired pneumonia (CAP). This showed that MLP was associated with increased mortality, OR 2.57 (95{\%} CI: 1.83–3.61), with no statistical heterogeneity (I2 = 0{\%}). Evidence from other settings suggests that MLP may also be associated with higher likelihood of other poor outcomes such as worsening clinical/radiological status, delayed resolution, and need for mechanical ventilation.ConclusionMLP appears to be an independent risk factor for mortality in CAP. It may be possible to improve commonly used prognostic indices in CAP by addition of MLP as a criterion.",
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AU - Pelpola, Kelum Nadeesha

AU - Myint, Phyo Kyaw

N1 - Copyright © 2013 European Federation of Internal Medicine. Published by Elsevier B.V. All rights reserved.

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N2 - BackgroundPneumonia is the leading cause of infection related mortality. Multilobar pneumonia (MLP) may have poorer outcomes and is a constituent of some prognostic indices. Our aim was to systematically-review and meta-analyse the impact of multi-lobar involvement in pneumonia.MethodsWe searched PubMed in June 2012 for studies reporting on the association between MLP and clinical outcomes. Potentially relevant studies were cross checked by two independent reviewers before final inclusion. Odds-ratios (OR) for the association between MLP and mortality, unfavourable outcomes, and poor treatment response were pooled using random effects meta-analysis.ResultsTwenty-two studies were included in this report. There were a total of 11,456 pneumonia patients including 2897 (25.3%) patients with MLP. As there was substantial clinical and statistical heterogeneity in the overall dataset, we limited the main meta-analysis to patients with community-acquired pneumonia (CAP). This showed that MLP was associated with increased mortality, OR 2.57 (95% CI: 1.83–3.61), with no statistical heterogeneity (I2 = 0%). Evidence from other settings suggests that MLP may also be associated with higher likelihood of other poor outcomes such as worsening clinical/radiological status, delayed resolution, and need for mechanical ventilation.ConclusionMLP appears to be an independent risk factor for mortality in CAP. It may be possible to improve commonly used prognostic indices in CAP by addition of MLP as a criterion.

AB - BackgroundPneumonia is the leading cause of infection related mortality. Multilobar pneumonia (MLP) may have poorer outcomes and is a constituent of some prognostic indices. Our aim was to systematically-review and meta-analyse the impact of multi-lobar involvement in pneumonia.MethodsWe searched PubMed in June 2012 for studies reporting on the association between MLP and clinical outcomes. Potentially relevant studies were cross checked by two independent reviewers before final inclusion. Odds-ratios (OR) for the association between MLP and mortality, unfavourable outcomes, and poor treatment response were pooled using random effects meta-analysis.ResultsTwenty-two studies were included in this report. There were a total of 11,456 pneumonia patients including 2897 (25.3%) patients with MLP. As there was substantial clinical and statistical heterogeneity in the overall dataset, we limited the main meta-analysis to patients with community-acquired pneumonia (CAP). This showed that MLP was associated with increased mortality, OR 2.57 (95% CI: 1.83–3.61), with no statistical heterogeneity (I2 = 0%). Evidence from other settings suggests that MLP may also be associated with higher likelihood of other poor outcomes such as worsening clinical/radiological status, delayed resolution, and need for mechanical ventilation.ConclusionMLP appears to be an independent risk factor for mortality in CAP. It may be possible to improve commonly used prognostic indices in CAP by addition of MLP as a criterion.

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