Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width

Hamideh Ghazizadeh; Mohammad Reza Mirinezhad; Seyed Mohammad Reza Seyedi; Fatemeh Sadabadi; Mahsa Ahmadnezhad; Naghme Jaberi; Alireza Pasdar; Gordon A. Ferns; Habibollah Esmaily; Majid Ghayour-Mobarhan

doi:10.1016/j.arcmed.2020.02.006

Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width

Hamideh Ghazizadeh, Mohammad Reza Mirinezhad, Seyed Mohammad Reza Seyedi, Fatemeh Sadabadi, Mahsa Ahmadnezhad, Naghme Jaberi, Alireza Pasdar, Gordon A. Ferns, Habibollah Esmaily, Majid Ghayour-Mobarhan^*

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

15 Citations (Scopus)

Abstract

Background. Several chronic diseases are mediated by oxidative stress. Oxidative stress affects cell morphology and function and is associated with alterations in the serum protein component. In the current study, we analyzed four individual prognostic factors associating with serum Pro-Oxidant-Antioxidant Balance (PAB): neutrophil to lymphocyte ratio (NLR), Vitamin D, anti-heat shock protein 27 (anti-hsp27) antibody titer, and red blood cell distribution width (RDW) to evaluate them as the potential prognostic markers. In the current study, we attempted to investigate the relationship between serum PAB, RDW, NLR, serum vitamin D and anti-hsp27 concentration.

Methods. A total of 852 participants (438 males and 414 females) aged 47.64 +/- 7.77 years were recruited in a cross-sectional study based on the Mashhad stroke and heart atherosclerotic disorders (MASHAD) cohort study data. Hematological parameters, and vitamin D, PAB and anti-hsp27 antibody titers were measured using the Sysmex auto analyzer system and enzyme-linked immune sorbent assay (ELISA), respectively.

Results. The results showed a significant correlation between Vitamin D and anti-hsp27 antibody titers (r = -0.13 and p 0.05) we found a significant association between serum PAB and serum anti hsp-27 antibody titers. Subjects with PAB levels 36.31-82.63 had a higher risk (1.83 fold) of having an increased anti-hsp27 antibody titers in comparison to the reference group (PAB level

Conclusion. The present study shows that serum vitamin D can be associated with reduction in inflammatory status probably by decreasing levels of serum anti-hsp27 antibody titers, reduction in oxidative stress and therefore may reduce the risk of cardiovascular diseases. Anti-hsp27 antibody titers are associated with oxidative stress through the serum PAB, therefore these factors may be of prognostic values in detecting oxidative stress and risk of atherosclerosis. The evaluation of these factors in a larger population may help further confirm these findings. (C) 2020 IMSS. Published by Elsevier Inc.

Original language	English
Pages (from-to)	261-267
Number of pages	7
Journal	Archives of medical research
Volume	51
Issue number	3
Early online date	26 Feb 2020
DOIs	https://doi.org/10.1016/j.arcmed.2020.02.006
Publication status	Published - 3 Apr 2020

Bibliographical note

Acknowledgments:
We would like to thank Mashhad University of Medical Sciences Research council for their financial support. The study was approved by the Ethics Committee of Mashhad University of Medical Sciences (Ethics number: IR.MUMS.REC.1386.250).
Funding: Research reported in this publication was supported by the Mashhad University of Medical Sciences, Mashhad, Iran.

Keywords

Red blood cell distribution width (RDW)
Pro-oxidant-antioxidant balance (PAB)
Neutrophil to lymphocyte ratio (NLR)
Vitamin D
anti-hsp27
Oxidative Stress/physiology
Prognosis
Neutrophils/cytology
Humans
Middle Aged
Erythrocyte Indices
Lymphocytes/cytology
Male
Adult
Biomarkers/blood
Female
Molecular Chaperones/immunology
Vitamin D/metabolism
Reactive Oxygen Species/metabolism
Antibodies/blood
Cross-Sectional Studies
Atherosclerosis/epidemiology
HSP27 Heat-Shock Proteins/immunology
Antioxidants/metabolism
Lymphocyte Count
Cohort Studies
Heat-Shock Proteins/immunology

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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Cite this

Ghazizadeh, H., Mirinezhad, M. R., Seyedi, S. M. R., Sadabadi, F., Ahmadnezhad, M., Jaberi, N., Pasdar, A., Ferns, G. A., Esmaily, H., & Ghayour-Mobarhan, M. (2020). Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width. Archives of medical research, 51(3), 261-267. https://doi.org/10.1016/j.arcmed.2020.02.006

Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width. / Ghazizadeh, Hamideh; Mirinezhad, Mohammad Reza; Seyedi, Seyed Mohammad Reza et al.
In: Archives of medical research, Vol. 51, No. 3, 03.04.2020, p. 261-267.

Research output: Contribution to journal › Article › peer-review

Ghazizadeh, H, Mirinezhad, MR, Seyedi, SMR, Sadabadi, F, Ahmadnezhad, M, Jaberi, N, Pasdar, A, Ferns, GA, Esmaily, H & Ghayour-Mobarhan, M 2020, 'Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width', Archives of medical research, vol. 51, no. 3, pp. 261-267. https://doi.org/10.1016/j.arcmed.2020.02.006

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abstract = "Background. Several chronic diseases are mediated by oxidative stress. Oxidative stress affects cell morphology and function and is associated with alterations in the serum protein component. In the current study, we analyzed four individual prognostic factors associating with serum Pro-Oxidant-Antioxidant Balance (PAB): neutrophil to lymphocyte ratio (NLR), Vitamin D, anti-heat shock protein 27 (anti-hsp27) antibody titer, and red blood cell distribution width (RDW) to evaluate them as the potential prognostic markers. In the current study, we attempted to investigate the relationship between serum PAB, RDW, NLR, serum vitamin D and anti-hsp27 concentration.Methods. A total of 852 participants (438 males and 414 females) aged 47.64 +/- 7.77 years were recruited in a cross-sectional study based on the Mashhad stroke and heart atherosclerotic disorders (MASHAD) cohort study data. Hematological parameters, and vitamin D, PAB and anti-hsp27 antibody titers were measured using the Sysmex auto analyzer system and enzyme-linked immune sorbent assay (ELISA), respectively.Results. The results showed a significant correlation between Vitamin D and anti-hsp27 antibody titers (r = -0.13 and p 0.05) we found a significant association between serum PAB and serum anti hsp-27 antibody titers. Subjects with PAB levels 36.31-82.63 had a higher risk (1.83 fold) of having an increased anti-hsp27 antibody titers in comparison to the reference group (PAB levelConclusion. The present study shows that serum vitamin D can be associated with reduction in inflammatory status probably by decreasing levels of serum anti-hsp27 antibody titers, reduction in oxidative stress and therefore may reduce the risk of cardiovascular diseases. Anti-hsp27 antibody titers are associated with oxidative stress through the serum PAB, therefore these factors may be of prognostic values in detecting oxidative stress and risk of atherosclerosis. The evaluation of these factors in a larger population may help further confirm these findings. (C) 2020 IMSS. Published by Elsevier Inc.",

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author = "Hamideh Ghazizadeh and Mirinezhad, {Mohammad Reza} and Seyedi, {Seyed Mohammad Reza} and Fatemeh Sadabadi and Mahsa Ahmadnezhad and Naghme Jaberi and Alireza Pasdar and Ferns, {Gordon A.} and Habibollah Esmaily and Majid Ghayour-Mobarhan",

note = "Acknowledgments: We would like to thank Mashhad University of Medical Sciences Research council for their financial support. The study was approved by the Ethics Committee of Mashhad University of Medical Sciences (Ethics number: IR.MUMS.REC.1386.250). Funding: Research reported in this publication was supported by the Mashhad University of Medical Sciences, Mashhad, Iran.",

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doi = "10.1016/j.arcmed.2020.02.006",

language = "English",

volume = "51",

pages = "261--267",

journal = "Archives of medical research",

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T1 - Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width

AU - Ghazizadeh, Hamideh

AU - Mirinezhad, Mohammad Reza

AU - Seyedi, Seyed Mohammad Reza

AU - Sadabadi, Fatemeh

AU - Ahmadnezhad, Mahsa

AU - Jaberi, Naghme

AU - Pasdar, Alireza

AU - Ferns, Gordon A.

AU - Esmaily, Habibollah

AU - Ghayour-Mobarhan, Majid

N1 - Acknowledgments: We would like to thank Mashhad University of Medical Sciences Research council for their financial support. The study was approved by the Ethics Committee of Mashhad University of Medical Sciences (Ethics number: IR.MUMS.REC.1386.250). Funding: Research reported in this publication was supported by the Mashhad University of Medical Sciences, Mashhad, Iran.

PY - 2020/4/3

Y1 - 2020/4/3

N2 - Background. Several chronic diseases are mediated by oxidative stress. Oxidative stress affects cell morphology and function and is associated with alterations in the serum protein component. In the current study, we analyzed four individual prognostic factors associating with serum Pro-Oxidant-Antioxidant Balance (PAB): neutrophil to lymphocyte ratio (NLR), Vitamin D, anti-heat shock protein 27 (anti-hsp27) antibody titer, and red blood cell distribution width (RDW) to evaluate them as the potential prognostic markers. In the current study, we attempted to investigate the relationship between serum PAB, RDW, NLR, serum vitamin D and anti-hsp27 concentration.Methods. A total of 852 participants (438 males and 414 females) aged 47.64 +/- 7.77 years were recruited in a cross-sectional study based on the Mashhad stroke and heart atherosclerotic disorders (MASHAD) cohort study data. Hematological parameters, and vitamin D, PAB and anti-hsp27 antibody titers were measured using the Sysmex auto analyzer system and enzyme-linked immune sorbent assay (ELISA), respectively.Results. The results showed a significant correlation between Vitamin D and anti-hsp27 antibody titers (r = -0.13 and p 0.05) we found a significant association between serum PAB and serum anti hsp-27 antibody titers. Subjects with PAB levels 36.31-82.63 had a higher risk (1.83 fold) of having an increased anti-hsp27 antibody titers in comparison to the reference group (PAB levelConclusion. The present study shows that serum vitamin D can be associated with reduction in inflammatory status probably by decreasing levels of serum anti-hsp27 antibody titers, reduction in oxidative stress and therefore may reduce the risk of cardiovascular diseases. Anti-hsp27 antibody titers are associated with oxidative stress through the serum PAB, therefore these factors may be of prognostic values in detecting oxidative stress and risk of atherosclerosis. The evaluation of these factors in a larger population may help further confirm these findings. (C) 2020 IMSS. Published by Elsevier Inc.

AB - Background. Several chronic diseases are mediated by oxidative stress. Oxidative stress affects cell morphology and function and is associated with alterations in the serum protein component. In the current study, we analyzed four individual prognostic factors associating with serum Pro-Oxidant-Antioxidant Balance (PAB): neutrophil to lymphocyte ratio (NLR), Vitamin D, anti-heat shock protein 27 (anti-hsp27) antibody titer, and red blood cell distribution width (RDW) to evaluate them as the potential prognostic markers. In the current study, we attempted to investigate the relationship between serum PAB, RDW, NLR, serum vitamin D and anti-hsp27 concentration.Methods. A total of 852 participants (438 males and 414 females) aged 47.64 +/- 7.77 years were recruited in a cross-sectional study based on the Mashhad stroke and heart atherosclerotic disorders (MASHAD) cohort study data. Hematological parameters, and vitamin D, PAB and anti-hsp27 antibody titers were measured using the Sysmex auto analyzer system and enzyme-linked immune sorbent assay (ELISA), respectively.Results. The results showed a significant correlation between Vitamin D and anti-hsp27 antibody titers (r = -0.13 and p 0.05) we found a significant association between serum PAB and serum anti hsp-27 antibody titers. Subjects with PAB levels 36.31-82.63 had a higher risk (1.83 fold) of having an increased anti-hsp27 antibody titers in comparison to the reference group (PAB levelConclusion. The present study shows that serum vitamin D can be associated with reduction in inflammatory status probably by decreasing levels of serum anti-hsp27 antibody titers, reduction in oxidative stress and therefore may reduce the risk of cardiovascular diseases. Anti-hsp27 antibody titers are associated with oxidative stress through the serum PAB, therefore these factors may be of prognostic values in detecting oxidative stress and risk of atherosclerosis. The evaluation of these factors in a larger population may help further confirm these findings. (C) 2020 IMSS. Published by Elsevier Inc.

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KW - Oxidative Stress/physiology

KW - Prognosis

KW - Neutrophils/cytology

KW - Humans

KW - Middle Aged

KW - Erythrocyte Indices

KW - Lymphocytes/cytology

KW - Male

KW - Adult

KW - Biomarkers/blood

KW - Female

KW - Molecular Chaperones/immunology

KW - Vitamin D/metabolism

KW - Reactive Oxygen Species/metabolism

KW - Antibodies/blood

KW - Cross-Sectional Studies

KW - Atherosclerosis/epidemiology

KW - HSP27 Heat-Shock Proteins/immunology

KW - Antioxidants/metabolism

KW - Lymphocyte Count

KW - Cohort Studies

KW - Heat-Shock Proteins/immunology

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Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width

Abstract

Bibliographical note

Keywords

UN SDGs

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