TY - JOUR
T1 - Prognostic Factors Associating with Pro-oxidant-antioxidant Balance; Neutrophils to Lymphocytes Ratio, Vitamin D, Heat Shock Protein 27, and Red Cell Distribution Width
AU - Ghazizadeh, Hamideh
AU - Mirinezhad, Mohammad Reza
AU - Seyedi, Seyed Mohammad Reza
AU - Sadabadi, Fatemeh
AU - Ahmadnezhad, Mahsa
AU - Jaberi, Naghme
AU - Pasdar, Alireza
AU - Ferns, Gordon A.
AU - Esmaily, Habibollah
AU - Ghayour-Mobarhan, Majid
N1 - Acknowledgments:
We would like to thank Mashhad University of Medical Sciences Research council for their financial support. The study was approved by the Ethics Committee of Mashhad University of Medical Sciences (Ethics number: IR.MUMS.REC.1386.250).
Funding: Research reported in this publication was supported by the Mashhad University of Medical Sciences, Mashhad, Iran.
PY - 2020/4/3
Y1 - 2020/4/3
N2 - Background. Several chronic diseases are mediated by oxidative stress. Oxidative stress affects cell morphology and function and is associated with alterations in the serum protein component. In the current study, we analyzed four individual prognostic factors associating with serum Pro-Oxidant-Antioxidant Balance (PAB): neutrophil to lymphocyte ratio (NLR), Vitamin D, anti-heat shock protein 27 (anti-hsp27) antibody titer, and red blood cell distribution width (RDW) to evaluate them as the potential prognostic markers. In the current study, we attempted to investigate the relationship between serum PAB, RDW, NLR, serum vitamin D and anti-hsp27 concentration.Methods. A total of 852 participants (438 males and 414 females) aged 47.64 +/- 7.77 years were recruited in a cross-sectional study based on the Mashhad stroke and heart atherosclerotic disorders (MASHAD) cohort study data. Hematological parameters, and vitamin D, PAB and anti-hsp27 antibody titers were measured using the Sysmex auto analyzer system and enzyme-linked immune sorbent assay (ELISA), respectively.Results. The results showed a significant correlation between Vitamin D and anti-hsp27 antibody titers (r = -0.13 and p 0.05) we found a significant association between serum PAB and serum anti hsp-27 antibody titers. Subjects with PAB levels 36.31-82.63 had a higher risk (1.83 fold) of having an increased anti-hsp27 antibody titers in comparison to the reference group (PAB levelConclusion. The present study shows that serum vitamin D can be associated with reduction in inflammatory status probably by decreasing levels of serum anti-hsp27 antibody titers, reduction in oxidative stress and therefore may reduce the risk of cardiovascular diseases. Anti-hsp27 antibody titers are associated with oxidative stress through the serum PAB, therefore these factors may be of prognostic values in detecting oxidative stress and risk of atherosclerosis. The evaluation of these factors in a larger population may help further confirm these findings. (C) 2020 IMSS. Published by Elsevier Inc.
AB - Background. Several chronic diseases are mediated by oxidative stress. Oxidative stress affects cell morphology and function and is associated with alterations in the serum protein component. In the current study, we analyzed four individual prognostic factors associating with serum Pro-Oxidant-Antioxidant Balance (PAB): neutrophil to lymphocyte ratio (NLR), Vitamin D, anti-heat shock protein 27 (anti-hsp27) antibody titer, and red blood cell distribution width (RDW) to evaluate them as the potential prognostic markers. In the current study, we attempted to investigate the relationship between serum PAB, RDW, NLR, serum vitamin D and anti-hsp27 concentration.Methods. A total of 852 participants (438 males and 414 females) aged 47.64 +/- 7.77 years were recruited in a cross-sectional study based on the Mashhad stroke and heart atherosclerotic disorders (MASHAD) cohort study data. Hematological parameters, and vitamin D, PAB and anti-hsp27 antibody titers were measured using the Sysmex auto analyzer system and enzyme-linked immune sorbent assay (ELISA), respectively.Results. The results showed a significant correlation between Vitamin D and anti-hsp27 antibody titers (r = -0.13 and p 0.05) we found a significant association between serum PAB and serum anti hsp-27 antibody titers. Subjects with PAB levels 36.31-82.63 had a higher risk (1.83 fold) of having an increased anti-hsp27 antibody titers in comparison to the reference group (PAB levelConclusion. The present study shows that serum vitamin D can be associated with reduction in inflammatory status probably by decreasing levels of serum anti-hsp27 antibody titers, reduction in oxidative stress and therefore may reduce the risk of cardiovascular diseases. Anti-hsp27 antibody titers are associated with oxidative stress through the serum PAB, therefore these factors may be of prognostic values in detecting oxidative stress and risk of atherosclerosis. The evaluation of these factors in a larger population may help further confirm these findings. (C) 2020 IMSS. Published by Elsevier Inc.
KW - Red blood cell distribution width (RDW)
KW - Pro-oxidant-antioxidant balance (PAB)
KW - Neutrophil to lymphocyte ratio (NLR)
KW - Vitamin D
KW - anti-hsp27
KW - Oxidative Stress/physiology
KW - Prognosis
KW - Neutrophils/cytology
KW - Humans
KW - Middle Aged
KW - Erythrocyte Indices
KW - Lymphocytes/cytology
KW - Male
KW - Adult
KW - Biomarkers/blood
KW - Female
KW - Molecular Chaperones/immunology
KW - Vitamin D/metabolism
KW - Reactive Oxygen Species/metabolism
KW - Antibodies/blood
KW - Cross-Sectional Studies
KW - Atherosclerosis/epidemiology
KW - HSP27 Heat-Shock Proteins/immunology
KW - Antioxidants/metabolism
KW - Lymphocyte Count
KW - Cohort Studies
KW - Heat-Shock Proteins/immunology
UR - http://www.scopus.com/inward/record.url?scp=85080062351&partnerID=8YFLogxK
U2 - 10.1016/j.arcmed.2020.02.006
DO - 10.1016/j.arcmed.2020.02.006
M3 - Article
C2 - 32111498
VL - 51
SP - 261
EP - 267
JO - Archives of medical research
JF - Archives of medical research
SN - 0188-4409
IS - 3
ER -
