Progress and challenges in analyzing rodent energy expenditure

Rodrigo Fernández-Verdejo, Eric Ravussin, John R Speakman, Jose E Galgani*

*Corresponding author for this work

Research output: Contribution to journalComment/debate

Abstract

Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.
Original languageEnglish
Pages (from-to)797-799
Number of pages3
JournalNature methods
Volume16
Early online date7 Aug 2019
DOIs
Publication statusPublished - Sep 2019

Fingerprint

Energy Metabolism
Rodentia
Body Size
Tissue

Keywords

  • MISUSE

ASJC Scopus subject areas

  • Molecular Biology
  • Biochemistry
  • Biotechnology
  • Cell Biology

Cite this

Progress and challenges in analyzing rodent energy expenditure. / Fernández-Verdejo, Rodrigo; Ravussin, Eric; Speakman, John R; Galgani, Jose E.

In: Nature methods, Vol. 16, 09.2019, p. 797-799.

Research output: Contribution to journalComment/debate

Fernández-Verdejo, Rodrigo ; Ravussin, Eric ; Speakman, John R ; Galgani, Jose E. / Progress and challenges in analyzing rodent energy expenditure. In: Nature methods. 2019 ; Vol. 16. pp. 797-799.
@article{a44dab86454c4977b14b4aed3b261853,
title = "Progress and challenges in analyzing rodent energy expenditure",
abstract = "Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.",
keywords = "MISUSE",
author = "Rodrigo Fern{\'a}ndez-Verdejo and Eric Ravussin and Speakman, {John R} and Galgani, {Jose E}",
note = "R.F.V. was supported by Fondecyt #11180361 (Conicyt, Chile). J.E.G was supported by Fondecyt #1170117 (Conicyt, Chile).",
year = "2019",
month = "9",
doi = "10.1038/s41592-019-0513-9",
language = "English",
volume = "16",
pages = "797--799",
journal = "Nature methods",
issn = "1548-7105",
publisher = "Nature Publishing Group",

}

TY - JOUR

T1 - Progress and challenges in analyzing rodent energy expenditure

AU - Fernández-Verdejo, Rodrigo

AU - Ravussin, Eric

AU - Speakman, John R

AU - Galgani, Jose E

N1 - R.F.V. was supported by Fondecyt #11180361 (Conicyt, Chile). J.E.G was supported by Fondecyt #1170117 (Conicyt, Chile).

PY - 2019/9

Y1 - 2019/9

N2 - Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.

AB - Whole-body energy expenditure is the summed metabolic activities of tissues and, to remove the influence of body size, ratios of energy expenditure to body mass are often applied but can generate spurious differences. In 2011, a group of experts proposed adoption of ANCOVA for the analysis of metabolic rate but, seven years later, analyses based on ratios remain the most frequent. We discuss some of the barriers to adopting better analytical procedures.

KW - MISUSE

UR - http://www.scopus.com/inward/record.url?scp=85070284724&partnerID=8YFLogxK

U2 - 10.1038/s41592-019-0513-9

DO - 10.1038/s41592-019-0513-9

M3 - Comment/debate

C2 - 31391589

VL - 16

SP - 797

EP - 799

JO - Nature methods

JF - Nature methods

SN - 1548-7105

ER -