Progress and Opportunities in Molecular Pathological Epidemiology of Colorectal Premalignant Lesions

Paul Lochhead, Andrew T Chan, Edward Giovannucci, Charles S Fuchs, Kana Wu, Reiko Nishihara, Michael O'Brien, Shuji Ogino

Research output: Contribution to journalArticle

32 Citations (Scopus)

Abstract

Molecular pathological epidemiology (MPE) is an integrative molecular and population health science that addresses the molecular pathogenesis and heterogeneity of disease processes. The MPE of colonic and rectal premalignant lesions (including hyperplastic polyps, tubular adenomas, tubulovillous adenomas, villous adenomas, traditional serrated adenomas, sessile serrated adenomas/sessile serrated polyps, and hamartomatous polyps) can provide unique opportunities for examining the influence of diet, lifestyle, and environmental exposures on specific pathways of carcinogenesis. Colorectal neoplasia can provide a practical model by which both malignant epithelial tumor (carcinoma) and its precursor are subjected to molecular pathological analyses. KRAS, BRAF, and PIK3CA oncogene mutations, microsatellite instability, CpG island methylator phenotype, and LINE-1 methylation are commonly examined tumor biomarkers. Future opportunities include interrogation of comprehensive genomic, epigenomic, or panomic datasets, and the adoption of in vivo pathology techniques. Considering the colorectal continuum hypothesis and emerging roles of gut microbiota and host immunity in tumorigenesis, detailed information on tumor location is important. There are unique strengths and caveats, especially with regard to case ascertainment by colonoscopy. The MPE of colorectal premalignant lesions can identify etiologic exposures associated with neoplastic initiation and progression, help us better understand colorectal carcinogenesis, and facilitate personalized prevention, screening, and therapy.Am J Gastroenterol advance online publication, 17 June 2014; doi:10.1038/ajg.2014.153.

Original languageEnglish
Pages (from-to)1205-1214
Number of pages10
JournalAmerican journal of gastroenterology
Volume109
Issue number8
Early online date17 Jun 2014
DOIs
Publication statusPublished - Aug 2014

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Molecular Epidemiology
Adenoma
Polyps
Carcinogenesis
Villous Adenoma
Carcinoma
Microsatellite Instability
CpG Islands
Environmental Exposure
Colonoscopy
Tumor Biomarkers
Oncogenes
Epigenomics
Methylation
Publications
Life Style
Immunity
Neoplasms
Pathology
Diet

Cite this

Lochhead, P., Chan, A. T., Giovannucci, E., Fuchs, C. S., Wu, K., Nishihara, R., ... Ogino, S. (2014). Progress and Opportunities in Molecular Pathological Epidemiology of Colorectal Premalignant Lesions. American journal of gastroenterology, 109(8), 1205-1214. https://doi.org/10.1038/ajg.2014.153

Progress and Opportunities in Molecular Pathological Epidemiology of Colorectal Premalignant Lesions. / Lochhead, Paul; Chan, Andrew T; Giovannucci, Edward; Fuchs, Charles S; Wu, Kana; Nishihara, Reiko; O'Brien, Michael; Ogino, Shuji.

In: American journal of gastroenterology, Vol. 109, No. 8, 08.2014, p. 1205-1214.

Research output: Contribution to journalArticle

Lochhead, P, Chan, AT, Giovannucci, E, Fuchs, CS, Wu, K, Nishihara, R, O'Brien, M & Ogino, S 2014, 'Progress and Opportunities in Molecular Pathological Epidemiology of Colorectal Premalignant Lesions', American journal of gastroenterology, vol. 109, no. 8, pp. 1205-1214. https://doi.org/10.1038/ajg.2014.153
Lochhead, Paul ; Chan, Andrew T ; Giovannucci, Edward ; Fuchs, Charles S ; Wu, Kana ; Nishihara, Reiko ; O'Brien, Michael ; Ogino, Shuji. / Progress and Opportunities in Molecular Pathological Epidemiology of Colorectal Premalignant Lesions. In: American journal of gastroenterology. 2014 ; Vol. 109, No. 8. pp. 1205-1214.
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