Progress in the identification of plasma biomarkers of colorectal cancer

Caroline Coghlin, Graeme I. Murray

Research output: Contribution to journalLiterature review

15 Citations (Scopus)

Abstract

Proteomic analysis of human tissue and plasma samples has been a useful tool in recent years for the identification of potential biomarkers to aid in the early diagnosis of colorectal cancer. However, biomarkers relating to the crucial transition between adenomatous lesions and invasive colorectal malignancy have not previously been described. The work of Choi et al. (Proteomics 2013, 13, 2361–2374) attempts to address this issue. Using plasma samples from age-matched patients with colorectal adenomas or invasive disease this group identified a range of plasma proteins and cytokines that were differentially expressed. This information not only provides insights into the biology of the adenoma to carcinoma progression sequence but it also represents a step towards the goal of achieving diagnostically accurate and clinically acceptable biomarkers in early colorectal cancer.
Original languageEnglish
Pages (from-to)2227-2228
Number of pages2
JournalProteomics
Volume13
Issue number15
Early online date2 Aug 2013
DOIs
Publication statusPublished - Aug 2013

Fingerprint

Biomarkers
Colorectal Neoplasms
Plasmas
Adenoma
Proteomics
Early Detection of Cancer
Blood Proteins
Tissue
Cytokines
Carcinoma
Neoplasms

Keywords

  • biomarker
  • biomedicine
  • colorectal cancer
  • screening

Cite this

Progress in the identification of plasma biomarkers of colorectal cancer. / Coghlin, Caroline; Murray, Graeme I.

In: Proteomics, Vol. 13, No. 15, 08.2013, p. 2227-2228.

Research output: Contribution to journalLiterature review

@article{0fd8908c70184b87ac59e5a4e096fc69,
title = "Progress in the identification of plasma biomarkers of colorectal cancer",
abstract = "Proteomic analysis of human tissue and plasma samples has been a useful tool in recent years for the identification of potential biomarkers to aid in the early diagnosis of colorectal cancer. However, biomarkers relating to the crucial transition between adenomatous lesions and invasive colorectal malignancy have not previously been described. The work of Choi et al. (Proteomics 2013, 13, 2361–2374) attempts to address this issue. Using plasma samples from age-matched patients with colorectal adenomas or invasive disease this group identified a range of plasma proteins and cytokines that were differentially expressed. This information not only provides insights into the biology of the adenoma to carcinoma progression sequence but it also represents a step towards the goal of achieving diagnostically accurate and clinically acceptable biomarkers in early colorectal cancer.",
keywords = "biomarker, biomedicine, colorectal cancer, screening",
author = "Caroline Coghlin and Murray, {Graeme I.}",
year = "2013",
month = "8",
doi = "10.1002/pmic.201300245",
language = "English",
volume = "13",
pages = "2227--2228",
journal = "Proteomics",
issn = "1615-9853",
publisher = "John Wiley & Sons, Ltd",
number = "15",

}

TY - JOUR

T1 - Progress in the identification of plasma biomarkers of colorectal cancer

AU - Coghlin, Caroline

AU - Murray, Graeme I.

PY - 2013/8

Y1 - 2013/8

N2 - Proteomic analysis of human tissue and plasma samples has been a useful tool in recent years for the identification of potential biomarkers to aid in the early diagnosis of colorectal cancer. However, biomarkers relating to the crucial transition between adenomatous lesions and invasive colorectal malignancy have not previously been described. The work of Choi et al. (Proteomics 2013, 13, 2361–2374) attempts to address this issue. Using plasma samples from age-matched patients with colorectal adenomas or invasive disease this group identified a range of plasma proteins and cytokines that were differentially expressed. This information not only provides insights into the biology of the adenoma to carcinoma progression sequence but it also represents a step towards the goal of achieving diagnostically accurate and clinically acceptable biomarkers in early colorectal cancer.

AB - Proteomic analysis of human tissue and plasma samples has been a useful tool in recent years for the identification of potential biomarkers to aid in the early diagnosis of colorectal cancer. However, biomarkers relating to the crucial transition between adenomatous lesions and invasive colorectal malignancy have not previously been described. The work of Choi et al. (Proteomics 2013, 13, 2361–2374) attempts to address this issue. Using plasma samples from age-matched patients with colorectal adenomas or invasive disease this group identified a range of plasma proteins and cytokines that were differentially expressed. This information not only provides insights into the biology of the adenoma to carcinoma progression sequence but it also represents a step towards the goal of achieving diagnostically accurate and clinically acceptable biomarkers in early colorectal cancer.

KW - biomarker

KW - biomedicine

KW - colorectal cancer

KW - screening

U2 - 10.1002/pmic.201300245

DO - 10.1002/pmic.201300245

M3 - Literature review

VL - 13

SP - 2227

EP - 2228

JO - Proteomics

JF - Proteomics

SN - 1615-9853

IS - 15

ER -