Progress in the identification of plasma biomarkers of colorectal cancer

Caroline Coghlin, Graeme I. Murray

Research output: Contribution to journalLiterature review

15 Citations (Scopus)

Abstract

Proteomic analysis of human tissue and plasma samples has been a useful tool in recent years for the identification of potential biomarkers to aid in the early diagnosis of colorectal cancer. However, biomarkers relating to the crucial transition between adenomatous lesions and invasive colorectal malignancy have not previously been described. The work of Choi et al. (Proteomics 2013, 13, 2361–2374) attempts to address this issue. Using plasma samples from age-matched patients with colorectal adenomas or invasive disease this group identified a range of plasma proteins and cytokines that were differentially expressed. This information not only provides insights into the biology of the adenoma to carcinoma progression sequence but it also represents a step towards the goal of achieving diagnostically accurate and clinically acceptable biomarkers in early colorectal cancer.
Original languageEnglish
Pages (from-to)2227-2228
Number of pages2
JournalProteomics
Volume13
Issue number15
Early online date2 Aug 2013
DOIs
Publication statusPublished - Aug 2013

Keywords

  • biomarker
  • biomedicine
  • colorectal cancer
  • screening

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