Progress toward whole-body proton-electron double-resonance imaging of free radicals

David J. Lurie

doi:10.1007/BF01705251

Progress toward whole-body proton-electron double-resonance imaging of free radicals

David J. Lurie^*

^*Corresponding author for this work

Applied Medicine

Research output: Contribution to journal › Article › peer-review

8 Citations (Scopus)

Abstract

Proton-electron double-resonance imaging (PEDRI) has been developed recently for imaging free radicals in biological samples and small animals. This article summarizes the techniques of PEDRI and the related field-cycled method, FC-PEDRI, and discusses the difficulties in scaling the techniques up to whole-body size. Imaging free radicals with broad EPR lines in humans would require excessive radiofrequency (RF) power, but the use of magnetic field cycling alleviates this problem and improves the signal-to-noise ratio. The results of computer simulations of field-cycled PEDRI are presented, which show that optimum EPR irradiation frequencies exist, depending on the free radical's electron relaxation times and on the applied RF power.

Original language	English
Pages (from-to)	267-271
Number of pages	5
Journal	Magma: Magnetic Resonance Materials in Physics, Biology, and Medicine
Volume	2
Issue number	3
DOIs	https://doi.org/10.1007/BF01705251
Publication status	Published - 1 Oct 1994

Keywords

DNP
double resonance
field cycling
free radicals
imaging

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10.1007/BF01705251

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title = "Progress toward whole-body proton-electron double-resonance imaging of free radicals",

abstract = "Proton-electron double-resonance imaging (PEDRI) has been developed recently for imaging free radicals in biological samples and small animals. This article summarizes the techniques of PEDRI and the related field-cycled method, FC-PEDRI, and discusses the difficulties in scaling the techniques up to whole-body size. Imaging free radicals with broad EPR lines in humans would require excessive radiofrequency (RF) power, but the use of magnetic field cycling alleviates this problem and improves the signal-to-noise ratio. The results of computer simulations of field-cycled PEDRI are presented, which show that optimum EPR irradiation frequencies exist, depending on the free radical's electron relaxation times and on the applied RF power.",

keywords = "DNP, double resonance, field cycling, free radicals, imaging",

author = "Lurie, {David J.}",

note = "The author thanks the Medical Research Council and the University of Aberdeen Research Committee for their continued support of this project. ",

year = "1994",

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T1 - Progress toward whole-body proton-electron double-resonance imaging of free radicals

AU - Lurie, David J.

N1 - The author thanks the Medical Research Council and the University of Aberdeen Research Committee for their continued support of this project.

PY - 1994/10/1

Y1 - 1994/10/1

N2 - Proton-electron double-resonance imaging (PEDRI) has been developed recently for imaging free radicals in biological samples and small animals. This article summarizes the techniques of PEDRI and the related field-cycled method, FC-PEDRI, and discusses the difficulties in scaling the techniques up to whole-body size. Imaging free radicals with broad EPR lines in humans would require excessive radiofrequency (RF) power, but the use of magnetic field cycling alleviates this problem and improves the signal-to-noise ratio. The results of computer simulations of field-cycled PEDRI are presented, which show that optimum EPR irradiation frequencies exist, depending on the free radical's electron relaxation times and on the applied RF power.

AB - Proton-electron double-resonance imaging (PEDRI) has been developed recently for imaging free radicals in biological samples and small animals. This article summarizes the techniques of PEDRI and the related field-cycled method, FC-PEDRI, and discusses the difficulties in scaling the techniques up to whole-body size. Imaging free radicals with broad EPR lines in humans would require excessive radiofrequency (RF) power, but the use of magnetic field cycling alleviates this problem and improves the signal-to-noise ratio. The results of computer simulations of field-cycled PEDRI are presented, which show that optimum EPR irradiation frequencies exist, depending on the free radical's electron relaxation times and on the applied RF power.

KW - DNP

KW - double resonance

KW - field cycling

KW - free radicals

KW - imaging

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JO - Magnetic Resonance Materials in Physics, Biology and Medicine

JF - Magnetic Resonance Materials in Physics, Biology and Medicine

SN - 0968-5243

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ER -

Progress toward whole-body proton-electron double-resonance imaging of free radicals

Abstract

Keywords

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