Progress toward whole-body proton-electron double-resonance imaging of free radicals

David J. Lurie*

*Corresponding author for this work

Research output: Contribution to journalArticle

8 Citations (Scopus)

Abstract

Proton-electron double-resonance imaging (PEDRI) has been developed recently for imaging free radicals in biological samples and small animals. This article summarizes the techniques of PEDRI and the related field-cycled method, FC-PEDRI, and discusses the difficulties in scaling the techniques up to whole-body size. Imaging free radicals with broad EPR lines in humans would require excessive radiofrequency (RF) power, but the use of magnetic field cycling alleviates this problem and improves the signal-to-noise ratio. The results of computer simulations of field-cycled PEDRI are presented, which show that optimum EPR irradiation frequencies exist, depending on the free radical's electron relaxation times and on the applied RF power.

Original languageEnglish
Pages (from-to)267-271
Number of pages5
JournalMagma: Magnetic Resonance Materials in Physics, Biology, and Medicine
Volume2
Issue number3
DOIs
Publication statusPublished - 1 Oct 1994

Keywords

  • DNP
  • double resonance
  • field cycling
  • free radicals
  • imaging

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