Progression of varicose veins and chronic venous insufficiency in the general population in the Edinburgh Vein Study

Amanda J. Lee, Lindsay A. Robertson, Sheila M. Boghossian, Paul L. Allan, C. Vaughan Ruckley, F. Gerald R Fowkes*, Christine J. Evans

*Corresponding author for this work

Research output: Contribution to journalArticle

41 Citations (Scopus)


Objective: The natural history in the general population of chronic venous disease in the legs is not well understood. This has limited our ability to predict which patients will deteriorate and to assign clinical priorities. The aims of this study were to describe the progression of trunk varicose veins and chronic venous insufficiency (CVI) in the general population, to identify important lifestyle and clinical prognostic factors, and to determine the relationship between venous reflux and progression.

Methods:The Edinburgh Vein Study is a population-based cohort study in which randomly selected adults aged 18 to 64 years had an examination at baseline. This included a questionnaire on lifestyle and clinical factors, standardized assessment and classification of venous disease in the legs, and duplex scan to detect venous reflux in eight segments of each leg. A follow-up examination 13 years later included a reclassification of venous disease to ascertain progression in the development or increase in severity of varicose veins and CVI
Original languageEnglish
Pages (from-to)18-26
Number of pages9
JournalJournal of Vascular Surgery: Venous and Lymphatic Disorders
Issue number1
Early online date1 Nov 2014
Publication statusPublished - 1 Jan 2015


ASJC Scopus subject areas

  • Cardiology and Cardiovascular Medicine
  • Surgery

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