Progressive genome-wide introgression in agricultural Campylobacter coli

Samuel K Sheppard; Xavier Didelot; Keith A Jolley; Aaron E Darling; Ben Pascoe; Guillaume Meric; David J Kelly; Alison Cody; Frances M Colles; Norval J C Strachan; Iain D Ogden; Ken Forbes; Nigel P French; Philip Carter; William G Miller; Noel D McCarthy; Robert Owen; Eva Litrup; Michael Egholm; Jason P Affourtit; Stephen D Bentley; Julian Parkhill; Martin C J Maiden; Daniel Falush

doi:10.1111/mec.12162

Progressive genome-wide introgression in agricultural Campylobacter coli

Samuel K Sheppard, Xavier Didelot, Keith A Jolley, Aaron E Darling, Ben Pascoe, Guillaume Meric, David J Kelly, Alison Cody, Frances M Colles, Norval J C Strachan, Iain D Ogden, Ken Forbes, Nigel P French, Philip Carter, William G Miller, Noel D McCarthy, Robert Owen, Eva Litrup, Michael Egholm, Jason P AffourtitStephen D Bentley, Julian Parkhill, Martin C J Maiden, Daniel Falush

Research output: Contribution to journal › Article › peer-review

100 Citations (Scopus)

Abstract

Hybridization between distantly related organisms can facilitate rapid adaptation to novel environments, but is potentially constrained by epistatic fitness interactions among cell components. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleotide level, corresponding to an average of nearly 40 amino acids per protein-coding gene. Using whole genome sequencing, we show that a single C. coli lineage, which has successfully colonized an agricultural niche, has been progressively accumulating C. jejuni DNA. Members of this lineage belong to two groups, the ST-828 and ST-1150 clonal complexes. The ST-1150 complex is less frequently isolated and has undergone a substantially greater amount of introgression leading to replacement of up to 23% of the C. coli core genome as well as import of novel DNA. By contrast, the more commonly isolated ST-828 complex bacteria have 10-11% introgressed DNA, and C. jejuni and nonagricultural C. coli lineages each have

Original language	English
Pages (from-to)	1051-1064
Number of pages	14
Journal	Molecular Ecology
Volume	22
Issue number	4
Early online date	20 Dec 2012
DOIs	https://doi.org/10.1111/mec.12162
Publication status	Published - Feb 2013

Keywords

adaptation
campylobacter
epistasis
genomics
introgression

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10.1111/mec.12162

Data from: Progressive genome-wide introgression in agricultural Campylobacter coli
Sheppard, S. K. (Creator), Didelot, X. (Creator), Jolley, K. A. (Creator), Darling, A. E. (Creator), Kelly, D. J. (Creator), Cody, A. J. (Creator), Colles, F. M. (Creator), Strachan, N. (Creator), Ogden, I. (Creator), Forbes, K. (Creator), French, N. P. (Creator), Carter, P. (Creator), Miller, W. G. (Creator), McCarthy, N. D. (Creator), Owen, R. (Creator), Litrup, E. (Creator), Egholm, M. (Creator), Bentley, S. D. (Creator), Parkhill, J. (Creator), Maiden, M. C. J. (Creator), Falush, D. (Creator), Affourtit, J. P. (Creator), Pascoe, B. (Creator), Meric, G. (Creator) & Edwards, P. (Data Manager), Dryad Digital Repository, 9 Nov 2012
DOI: 10.5061/dryad.215jd
Dataset

Cite this

Sheppard, S. K., Didelot, X., Jolley, K. A., Darling, A. E., Pascoe, B., Meric, G., Kelly, D. J., Cody, A., Colles, F. M., Strachan, N. J. C., Ogden, I. D., Forbes, K., French, N. P., Carter, P., Miller, W. G., McCarthy, N. D., Owen, R., Litrup, E., Egholm, M., ... Falush, D. (2013). Progressive genome-wide introgression in agricultural Campylobacter coli. Molecular Ecology, 22(4), 1051-1064. https://doi.org/10.1111/mec.12162

Sheppard, SK, Didelot, X, Jolley, KA, Darling, AE, Pascoe, B, Meric, G, Kelly, DJ, Cody, A, Colles, FM, Strachan, NJC, Ogden, ID, Forbes, K, French, NP, Carter, P, Miller, WG, McCarthy, ND, Owen, R, Litrup, E, Egholm, M, Affourtit, JP, Bentley, SD, Parkhill, J, Maiden, MCJ & Falush, D 2013, 'Progressive genome-wide introgression in agricultural Campylobacter coli', Molecular Ecology, vol. 22, no. 4, pp. 1051-1064. https://doi.org/10.1111/mec.12162

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abstract = "Hybridization between distantly related organisms can facilitate rapid adaptation to novel environments, but is potentially constrained by epistatic fitness interactions among cell components. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleotide level, corresponding to an average of nearly 40 amino acids per protein-coding gene. Using whole genome sequencing, we show that a single C. coli lineage, which has successfully colonized an agricultural niche, has been progressively accumulating C. jejuni DNA. Members of this lineage belong to two groups, the ST-828 and ST-1150 clonal complexes. The ST-1150 complex is less frequently isolated and has undergone a substantially greater amount of introgression leading to replacement of up to 23% of the C. coli core genome as well as import of novel DNA. By contrast, the more commonly isolated ST-828 complex bacteria have 10-11% introgressed DNA, and C. jejuni and nonagricultural C. coli lineages each have ",

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author = "Sheppard, {Samuel K} and Xavier Didelot and Jolley, {Keith A} and Darling, {Aaron E} and Ben Pascoe and Guillaume Meric and Kelly, {David J} and Alison Cody and Colles, {Frances M} and Strachan, {Norval J C} and Ogden, {Iain D} and Ken Forbes and French, {Nigel P} and Philip Carter and Miller, {William G} and McCarthy, {Noel D} and Robert Owen and Eva Litrup and Michael Egholm and Affourtit, {Jason P} and Bentley, {Stephen D} and Julian Parkhill and Maiden, {Martin C J} and Daniel Falush",

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AU - Bentley, Stephen D

AU - Parkhill, Julian

AU - Maiden, Martin C J

AU - Falush, Daniel

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AB - Hybridization between distantly related organisms can facilitate rapid adaptation to novel environments, but is potentially constrained by epistatic fitness interactions among cell components. The zoonotic pathogens Campylobacter coli and C. jejuni differ from each other by around 15% at the nucleotide level, corresponding to an average of nearly 40 amino acids per protein-coding gene. Using whole genome sequencing, we show that a single C. coli lineage, which has successfully colonized an agricultural niche, has been progressively accumulating C. jejuni DNA. Members of this lineage belong to two groups, the ST-828 and ST-1150 clonal complexes. The ST-1150 complex is less frequently isolated and has undergone a substantially greater amount of introgression leading to replacement of up to 23% of the C. coli core genome as well as import of novel DNA. By contrast, the more commonly isolated ST-828 complex bacteria have 10-11% introgressed DNA, and C. jejuni and nonagricultural C. coli lineages each have

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KW - epistasis

KW - genomics

KW - introgression

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DO - 10.1111/mec.12162

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Progressive genome-wide introgression in agricultural Campylobacter coli

Abstract

Keywords

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Data from: Progressive genome-wide introgression in agricultural Campylobacter coli

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