Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)

N. Maina, J. M. Ngotho, T. Were, J. K. Thuita, D. M. Mwangangi, J. M. Kagira, J. M. Ndung'u, Jeremy M Sternberg

Research output: Contribution to journalArticle

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Abstract

A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

Original languageEnglish
Pages (from-to)3063-3065
Number of pages2
JournalInfection and Immunity
Volume72
Issue number5
DOIs
Publication statusPublished - 2004

Keywords

  • CENTRAL-NERVOUS-SYSTEM
  • TUMOR-NECROSIS-FACTOR
  • AFRICAN TRYPANOSOMIASIS
  • NITRIC-OXIDE
  • INTERFERON-GAMMA
  • MICE
  • ACTIVATION

Cite this

Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops). / Maina, N.; Ngotho, J. M.; Were, T.; Thuita, J. K.; Mwangangi, D. M.; Kagira, J. M.; Ndung'u, J. M.; Sternberg, Jeremy M.

In: Infection and Immunity, Vol. 72, No. 5, 2004, p. 3063-3065.

Research output: Contribution to journalArticle

Maina, N. ; Ngotho, J. M. ; Were, T. ; Thuita, J. K. ; Mwangangi, D. M. ; Kagira, J. M. ; Ndung'u, J. M. ; Sternberg, Jeremy M. / Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops). In: Infection and Immunity. 2004 ; Vol. 72, No. 5. pp. 3063-3065.
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AU - Maina, N.

AU - Ngotho, J. M.

AU - Were, T.

AU - Thuita, J. K.

AU - Mwangangi, D. M.

AU - Kagira, J. M.

AU - Ndung'u, J. M.

AU - Sternberg, Jeremy M

PY - 2004

Y1 - 2004

N2 - A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

AB - A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

KW - CENTRAL-NERVOUS-SYSTEM

KW - TUMOR-NECROSIS-FACTOR

KW - AFRICAN TRYPANOSOMIASIS

KW - NITRIC-OXIDE

KW - INTERFERON-GAMMA

KW - MICE

KW - ACTIVATION

U2 - 10.1128/IAI.72.5.3063-3065.2004

DO - 10.1128/IAI.72.5.3063-3065.2004

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JO - Infection and Immunity

JF - Infection and Immunity

SN - 0019-9567

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ER -