Proinflammatory cytokine expression in the early phase of Trypanosoma brucei rhodesiense infection in vervet monkeys (Cercopithecus aethiops)

N. Maina, J. M. Ngotho, T. Were, J. K. Thuita, D. M. Mwangangi, J. M. Kagira, J. M. Ndung'u, Jeremy M Sternberg

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Abstract

A vervet monkey model of trypanosomiasis was used to study inflammatory cytokine responses in serum and cerebrospinal fuid (CSF). Gamma interferon levels were transiently up-regulated in serum between days 6 and 8 of infection, followed by a sustained up-regulation of tumor necrosis factor alpha (TNF-alpha) and soluble TNF receptor 1. At no time were these cytokines detectable in the CSF.

Original languageEnglish
Pages (from-to)3063-3065
Number of pages2
JournalInfection and Immunity
Volume72
Issue number5
DOIs
Publication statusPublished - 2004

Keywords

  • CENTRAL-NERVOUS-SYSTEM
  • TUMOR-NECROSIS-FACTOR
  • AFRICAN TRYPANOSOMIASIS
  • NITRIC-OXIDE
  • INTERFERON-GAMMA
  • MICE
  • ACTIVATION

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