Projections from the Dorsomedial Division of the Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei in the Mouse

Marie Barbier; J. Antonio González; Christophe  Houdayer; Denis Burdakov; Pierre‐Yves  Risold; Sophie  Croizier

doi:10.1002/cne.24988

Projections from the Dorsomedial Division of the Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei in the Mouse

Marie Barbier, J. Antonio González, Christophe Houdayer , Denis Burdakov, Pierre‐Yves Risold, Sophie Croizier^* (Corresponding Author)

^*Corresponding author for this work

The Rowett Institute of Nutrition and Health

Research output: Contribution to journal › Article › peer-review

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Abstract

As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti‐related peptide (AgRP), melanin‐concentrating‐hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST.
Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress‐related feeding behaviors.

Original language	English
Pages (from-to)	929-956
Number of pages	28
Journal	Journal of Comparative Neurology
Volume	529
Issue number	5
Early online date	3 Aug 2020
DOIs	https://doi.org/10.1002/cne.24988
Publication status	Published - 1 Apr 2021

Bibliographical note

Acknowledgments: All the authors contributed to perform the experiments. SC designed the experiments, analyzed the data and wrote the paper. MB, JAG, DB and PYR edited the manuscript. This work was supported by the Region Franche-Comté, France (PYR), by The Francis Crick Institute (DB), by the Swiss National Science Foundation (PZ00P3_167934/1) and the Novartis Foundation for medical-biological research (19B145) (SC)
The data that support the findings of this study are available from the corresponding author upon reasonable request.

Keywords

dorsomedial division of the bed nucleus of the stria terminalis
hypothalamic nuclei
MCH
ORX
POMC
AgRP/NPY
anterograde and retrograde tract tracing

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Cite this

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title = "Projections from the Dorsomedial Division of the Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei in the Mouse",

abstract = "As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti‐related peptide (AgRP), melanin‐concentrating‐hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST.Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress‐related feeding behaviors.",

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author = "Marie Barbier and Gonz{\'a}lez, {J. Antonio} and Christophe Houdayer and Denis Burdakov and Pierre‐Yves Risold and Sophie Croizier",

note = "Acknowledgments: All the authors contributed to perform the experiments. SC designed the experiments, analyzed the data and wrote the paper. MB, JAG, DB and PYR edited the manuscript. This work was supported by the Region Franche-Comt{\'e}, France (PYR), by The Francis Crick Institute (DB), by the Swiss National Science Foundation (PZ00P3_167934/1) and the Novartis Foundation for medical-biological research (19B145) (SC) The data that support the findings of this study are available from the corresponding author upon reasonable request. ",

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AU - Risold, Pierre‐Yves

AU - Croizier, Sophie

N1 - Acknowledgments: All the authors contributed to perform the experiments. SC designed the experiments, analyzed the data and wrote the paper. MB, JAG, DB and PYR edited the manuscript. This work was supported by the Region Franche-Comté, France (PYR), by The Francis Crick Institute (DB), by the Swiss National Science Foundation (PZ00P3_167934/1) and the Novartis Foundation for medical-biological research (19B145) (SC) The data that support the findings of this study are available from the corresponding author upon reasonable request.

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N2 - As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti‐related peptide (AgRP), melanin‐concentrating‐hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST.Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress‐related feeding behaviors.

AB - As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti‐related peptide (AgRP), melanin‐concentrating‐hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST.Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress‐related feeding behaviors.

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JF - Journal of Comparative Neurology

IS - 5

ER -

Projections from the Dorsomedial Division of the Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei in the Mouse

Abstract

Bibliographical note

Keywords

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