Projections from the Dorsomedial Division of the Bed Nucleus of the Stria Terminalis to Hypothalamic Nuclei in the Mouse

Marie Barbier, J. Antonio González, Christophe Houdayer , Denis Burdakov, Pierre‐Yves Risold, Sophie Croizier* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalArticle

Abstract

As stressful environment is a potent modulator of feeding, we seek in the present work to decipher the neuroanatomical basis for an interplay between stress and feeding behaviors. For this, we combined anterograde and retrograde tracing with immunohistochemical approaches to investigate the patterns of projections between the dorsomedial division of the bed nucleus of the stria terminalis (BNST), well connected to the amygdala, and hypothalamic structures such as the paraventricular (PVH) and dorsomedial (DMH), the arcuate (ARH) nuclei and the lateral hypothalamic areas (LHA) known to control feeding and motivated behaviors. We particularly focused our study on afferences to proopiomelanocortin (POMC), agouti‐related peptide (AgRP), melanin‐concentrating‐hormone (MCH) and orexin (ORX) neurons characteristics of the ARH and the LHA, respectively. We found light to intense innervation of all these hypothalamic nuclei. We particularly showed an innervation of POMC, AgRP, MCH and ORX neurons by the dorsomedial and dorsolateral divisions of the BNST.
Therefore, these results lay the foundation for a better understanding of the neuroanatomical basis of the stress‐related feeding behaviors.
Original languageEnglish
Number of pages28
JournalJournal of Comparative Neurology
Early online date3 Aug 2020
DOIs
Publication statusE-pub ahead of print - 3 Aug 2020

Keywords

  • dorsomedial division of the bed nucleus of the stria terminalis
  • hypothalamic nuclei
  • MCH
  • ORX
  • POMC
  • AgRP/NPY
  • anterograde and retrograde tract tracing
  • RAT
  • FOOD-INTAKE
  • ARCUATE NUCLEUS
  • ORGANIZATION
  • PARAVENTRICULAR NUCLEUS
  • NPY
  • NEURONS
  • AgRP
  • MELANIN-CONCENTRATING HORMONE
  • STRESS
  • BRAIN
  • MODULATION

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