Proliferation is associated with 2-Deoxy-D-[1-3H]glucose uptake by T47D breast tumour and SW480 and SW620 colonic tumour cells

Timothy Andrew Davies Smith, Jenny Titley, Ralph McReady

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Abstract

The interpretation of therapy-induced changes in the uptake of fluorodeoxyglucose by tumours, detected using PET, is dependent on which tumour characteristics are associated with its uptake. In this study the relationship between proliferation (S-phase fraction) and the uptake of 2-deoxy-d-[1-3H]glucose by T47D breast tumour and SW480 and SW620 colonic tumour cells was measured between 2 and 12 days after seeding. Strong correlations (p < 0.001) were observed between viable cell number and the uptake of 2-deoxy-d-[1-3H]glucose/flask by each of the cell lines. Uptake of this compound was also found to correlate with S phase fraction in the T47D line (p < 0.05) and the SW480 (p < 0.01) and the SW620 (p < 0.001) colonic tumour lines. The findings of the present study suggest that therapy-induced changs in the uptake of this compound may at least partially reflect changes in proliferative fraction.
Original languageEnglish
Pages (from-to)281-285
Number of pages5
JournalNuclear Medicine and Biology
Volume25
Issue number5
DOIs
Publication statusPublished - Jul 1998

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Keywords

  • deoxyglucose
  • proliferation
  • tumour cell lines

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