Proliferation is associated with 2-Deoxy-D-[1-3H]glucose uptake by T47D breast tumour and SW480 and SW620 colonic tumour cells

Timothy Andrew Davies Smith; Jenny Titley; Ralph McReady

doi:10.1016/S0969-8051(98)00014-6

Proliferation is associated with 2-Deoxy-D-[1-3H]glucose uptake by T47D breast tumour and SW480 and SW620 colonic tumour cells

Timothy Andrew Davies Smith, Jenny Titley, Ralph McReady

Applied Medicine

Research output: Contribution to journal › Article › peer-review

14 Citations (Scopus)

Abstract

The interpretation of therapy-induced changes in the uptake of fluorodeoxyglucose by tumours, detected using PET, is dependent on which tumour characteristics are associated with its uptake. In this study the relationship between proliferation (S-phase fraction) and the uptake of 2-deoxy-d-[1-3H]glucose by T47D breast tumour and SW480 and SW620 colonic tumour cells was measured between 2 and 12 days after seeding. Strong correlations (p < 0.001) were observed between viable cell number and the uptake of 2-deoxy-d-[1-3H]glucose/flask by each of the cell lines. Uptake of this compound was also found to correlate with S phase fraction in the T47D line (p < 0.05) and the SW480 (p < 0.01) and the SW620 (p < 0.001) colonic tumour lines. The findings of the present study suggest that therapy-induced changs in the uptake of this compound may at least partially reflect changes in proliferative fraction.

Original language	English
Pages (from-to)	281-285
Number of pages	5
Journal	Nuclear Medicine and Biology
Volume	25
Issue number	5
DOIs	https://doi.org/10.1016/S0969-8051(98)00014-6
Publication status	Published - Jul 1998

Keywords

deoxyglucose
proliferation
tumour cell lines

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@article{38c62560a23e4190bbdd3183ae7e4353,

title = "Proliferation is associated with 2-Deoxy-D-[1-3H]glucose uptake by T47D breast tumour and SW480 and SW620 colonic tumour cells",

abstract = "The interpretation of therapy-induced changes in the uptake of fluorodeoxyglucose by tumours, detected using PET, is dependent on which tumour characteristics are associated with its uptake. In this study the relationship between proliferation (S-phase fraction) and the uptake of 2-deoxy-d-[1-3H]glucose by T47D breast tumour and SW480 and SW620 colonic tumour cells was measured between 2 and 12 days after seeding. Strong correlations (p < 0.001) were observed between viable cell number and the uptake of 2-deoxy-d-[1-3H]glucose/flask by each of the cell lines. Uptake of this compound was also found to correlate with S phase fraction in the T47D line (p < 0.05) and the SW480 (p < 0.01) and the SW620 (p < 0.001) colonic tumour lines. The findings of the present study suggest that therapy-induced changs in the uptake of this compound may at least partially reflect changes in proliferative fraction.",

keywords = "deoxyglucose, proliferation, tumour cell lines",

author = "Smith, {Timothy Andrew Davies} and Jenny Titley and Ralph McReady",

note = "The financial support of the Royal Marsden NHS Trust and the Institute of Cancer Research is gratefully acknowledged.",

year = "1998",

month = jul,

doi = "10.1016/S0969-8051(98)00014-6",

language = "English",

volume = "25",

pages = "281--285",

journal = "Nuclear Medicine and Biology",

issn = "0969-8051",

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TY - JOUR

T1 - Proliferation is associated with 2-Deoxy-D-[1-3H]glucose uptake by T47D breast tumour and SW480 and SW620 colonic tumour cells

AU - Smith, Timothy Andrew Davies

AU - Titley, Jenny

AU - McReady, Ralph

N1 - The financial support of the Royal Marsden NHS Trust and the Institute of Cancer Research is gratefully acknowledged.

PY - 1998/7

Y1 - 1998/7

N2 - The interpretation of therapy-induced changes in the uptake of fluorodeoxyglucose by tumours, detected using PET, is dependent on which tumour characteristics are associated with its uptake. In this study the relationship between proliferation (S-phase fraction) and the uptake of 2-deoxy-d-[1-3H]glucose by T47D breast tumour and SW480 and SW620 colonic tumour cells was measured between 2 and 12 days after seeding. Strong correlations (p < 0.001) were observed between viable cell number and the uptake of 2-deoxy-d-[1-3H]glucose/flask by each of the cell lines. Uptake of this compound was also found to correlate with S phase fraction in the T47D line (p < 0.05) and the SW480 (p < 0.01) and the SW620 (p < 0.001) colonic tumour lines. The findings of the present study suggest that therapy-induced changs in the uptake of this compound may at least partially reflect changes in proliferative fraction.

AB - The interpretation of therapy-induced changes in the uptake of fluorodeoxyglucose by tumours, detected using PET, is dependent on which tumour characteristics are associated with its uptake. In this study the relationship between proliferation (S-phase fraction) and the uptake of 2-deoxy-d-[1-3H]glucose by T47D breast tumour and SW480 and SW620 colonic tumour cells was measured between 2 and 12 days after seeding. Strong correlations (p < 0.001) were observed between viable cell number and the uptake of 2-deoxy-d-[1-3H]glucose/flask by each of the cell lines. Uptake of this compound was also found to correlate with S phase fraction in the T47D line (p < 0.05) and the SW480 (p < 0.01) and the SW620 (p < 0.001) colonic tumour lines. The findings of the present study suggest that therapy-induced changs in the uptake of this compound may at least partially reflect changes in proliferative fraction.

KW - deoxyglucose

KW - proliferation

KW - tumour cell lines

U2 - 10.1016/S0969-8051(98)00014-6

DO - 10.1016/S0969-8051(98)00014-6

M3 - Article

VL - 25

SP - 281

EP - 285

JO - Nuclear Medicine and Biology

JF - Nuclear Medicine and Biology

SN - 0969-8051

IS - 5

ER -

Proliferation is associated with 2-Deoxy-D-[1-3H]glucose uptake by T47D breast tumour and SW480 and SW620 colonic tumour cells

Abstract

Keywords

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