Prospective analysis of Body Mass Index, physical activity, and colorectal cancer risk associated with β-catenin (CTNNB1) status

Teppei Morikawa, Aya Kuchiba, Paul Lochhead, Reiko Nishihara, Mai Yamauchi, Yu Imamura, Xiaoyun Liao, Zhi Rong Qian, Kimmie Ng, Andrew T Chan, Jeffrey A Meyerhardt, Edward Giovannucci, Charles S Fuchs, Shuji Ogino

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Abstract

Dysregulation of the WNT/β-catenin (CTNNB1) signaling pathway is implicated in colorectal carcinoma and metabolic diseases. Considering these roles and cancer prevention, we hypothesized that tumor CTNNB1 status might influence cellular sensitivity to obesity and physical activity. In clinical follow-up of 109,046 women in the Nurses' Health Study and 47,684 men in the Health Professionals Follow-up Study, there were 861 incident rectal and colon cancers with tissue immunohistochemistry data on nuclear CTNNB1 expression. Using this molecular pathological epidemiology database, we conducted Cox proportional hazards regression analysis using data duplication method to assess differential associations of body mass index (BMI) or exercise activity with colorectal cancer risk according to tumor CTNNB1 status. Greater BMI was associated with a significantly higher risk of CTNNB1-negative cancer [multivariate HR = 1.34; 95% confidence interval (CI), 1.18–1.53 for 5.0 kg/m2 increment; Ptrend = 0.0001] but not with CTNNB1-positive cancer risk (multivariate HR = 1.07; 95% CI, 0.92–1.25 for 5.0 kg/m2 increment; Ptrend = 0.36; Pheterogeneity = 0.027, between CTNNB1-negative and CTNNB1-positive cancer risks). Physical activity level was associated with a lower risk of CTNNB1-negative cancer (multivariate HR = 0.93; 95% CI, 0.87–1.00 for 10 MET-h/wk increment; Ptrend = 0.044) but not with CTNNB1-positive cancer risk (multivariate HR = 0.98; 95% CI, 0.91–1.05 for 10 MET-h/wk increment; Ptrend = 0.60). Our findings argue that obesity and physical inactivity are associated with a higher risk of CTNNB1-negative colorectal cancer but not with CTNNB1-positive cancer risk. Furthermore, they suggest that energy balance and metabolism status exerts its effect in a specific carcinogenesis pathway that is less likely dependent on WNT/CTNNB1 activation. Cancer Res; 73(5); 1600–10. ©2012 AACR.
Original languageEnglish
Article number1600
Number of pages12
JournalCancer Research
Volume73
Issue number5
DOIs
Publication statusPublished - 1 Mar 2013

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Catenins
Colorectal Neoplasms
Body Mass Index
Exercise
Neoplasms
Confidence Intervals
Obesity
Men's Health
Molecular Epidemiology
Metabolic Diseases
Rectal Neoplasms
Colonic Neoplasms
Energy Metabolism
Carcinogenesis
Immunohistochemistry
Nurses
Regression Analysis
Databases

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Prospective analysis of Body Mass Index, physical activity, and colorectal cancer risk associated with β-catenin (CTNNB1) status. / Morikawa, Teppei; Kuchiba, Aya; Lochhead, Paul; Nishihara, Reiko; Yamauchi, Mai; Imamura, Yu; Liao, Xiaoyun; Qian, Zhi Rong; Ng, Kimmie; Chan, Andrew T; Meyerhardt, Jeffrey A; Giovannucci, Edward; Fuchs, Charles S; Ogino, Shuji.

In: Cancer Research, Vol. 73, No. 5, 1600, 01.03.2013.

Research output: Contribution to journalArticle

Morikawa, T, Kuchiba, A, Lochhead, P, Nishihara, R, Yamauchi, M, Imamura, Y, Liao, X, Qian, ZR, Ng, K, Chan, AT, Meyerhardt, JA, Giovannucci, E, Fuchs, CS & Ogino, S 2013, 'Prospective analysis of Body Mass Index, physical activity, and colorectal cancer risk associated with β-catenin (CTNNB1) status', Cancer Research, vol. 73, no. 5, 1600. https://doi.org/10.1158/0008-5472.CAN-12-2276
Morikawa, Teppei ; Kuchiba, Aya ; Lochhead, Paul ; Nishihara, Reiko ; Yamauchi, Mai ; Imamura, Yu ; Liao, Xiaoyun ; Qian, Zhi Rong ; Ng, Kimmie ; Chan, Andrew T ; Meyerhardt, Jeffrey A ; Giovannucci, Edward ; Fuchs, Charles S ; Ogino, Shuji. / Prospective analysis of Body Mass Index, physical activity, and colorectal cancer risk associated with β-catenin (CTNNB1) status. In: Cancer Research. 2013 ; Vol. 73, No. 5.
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AU - Yamauchi, Mai

AU - Imamura, Yu

AU - Liao, Xiaoyun

AU - Qian, Zhi Rong

AU - Ng, Kimmie

AU - Chan, Andrew T

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AB - Dysregulation of the WNT/β-catenin (CTNNB1) signaling pathway is implicated in colorectal carcinoma and metabolic diseases. Considering these roles and cancer prevention, we hypothesized that tumor CTNNB1 status might influence cellular sensitivity to obesity and physical activity. In clinical follow-up of 109,046 women in the Nurses' Health Study and 47,684 men in the Health Professionals Follow-up Study, there were 861 incident rectal and colon cancers with tissue immunohistochemistry data on nuclear CTNNB1 expression. Using this molecular pathological epidemiology database, we conducted Cox proportional hazards regression analysis using data duplication method to assess differential associations of body mass index (BMI) or exercise activity with colorectal cancer risk according to tumor CTNNB1 status. Greater BMI was associated with a significantly higher risk of CTNNB1-negative cancer [multivariate HR = 1.34; 95% confidence interval (CI), 1.18–1.53 for 5.0 kg/m2 increment; Ptrend = 0.0001] but not with CTNNB1-positive cancer risk (multivariate HR = 1.07; 95% CI, 0.92–1.25 for 5.0 kg/m2 increment; Ptrend = 0.36; Pheterogeneity = 0.027, between CTNNB1-negative and CTNNB1-positive cancer risks). Physical activity level was associated with a lower risk of CTNNB1-negative cancer (multivariate HR = 0.93; 95% CI, 0.87–1.00 for 10 MET-h/wk increment; Ptrend = 0.044) but not with CTNNB1-positive cancer risk (multivariate HR = 0.98; 95% CI, 0.91–1.05 for 10 MET-h/wk increment; Ptrend = 0.60). Our findings argue that obesity and physical inactivity are associated with a higher risk of CTNNB1-negative colorectal cancer but not with CTNNB1-positive cancer risk. Furthermore, they suggest that energy balance and metabolism status exerts its effect in a specific carcinogenesis pathway that is less likely dependent on WNT/CTNNB1 activation. Cancer Res; 73(5); 1600–10. ©2012 AACR.

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