Prospective guidance in a free-swimming cell

Jonathan T. Delafield-Butt, Gert Jan Pepping, Colin D. McCaig, David N. Lee

Research output: Contribution to journalReview article

6 Citations (Scopus)

Abstract

Abstract A systems theory of movement control in animals is presented in this article and applied to explaining the controlled behaviour of the single-celledParamecium caudatum in an electric field. The theory-General Tau Theory-is founded on three basic principles: (i) all purposivemovement entails prospectively controlling the closure of action-gaps (e.g. a distance gap when reaching, or an angle gap when steering); (ii) the sole informational variable required for controlling gaps is the relative rate of change of the gap (the time derivative of the gap size divided by the size), which can be directly sensed; and (iii) a coordinated movement is achieved by keeping the relative rates of change of gaps in a constant ratio. The theory is supported by studies of controlled movement in mammals, birds and insects. We now show for the first time that it is also supported by single-celled paramecia steering to the cathode in a bi-polar electric field. General Tau Theory is deployed to explain this guided steering by the cell. This article presents the first computational model of prospective perceptual control in a non-neural, single-celled system.

Original languageEnglish
Pages (from-to)283-293
Number of pages11
JournalBiological Cybernetics
Volume106
Issue number4-5
Early online date22 Jun 2012
DOIs
Publication statusPublished - Jul 2012

Fingerprint

Electric fields
Paramecium
Urodela
Systems Theory
Mammals
Birds
System theory
Insects
Electrodes
Animals
Cathodes
Derivatives
Swimming

Keywords

  • Cellular guidance
  • Galvanotaxis
  • General Tau Theory
  • Paramecium
  • Tau-coupling

ASJC Scopus subject areas

  • Biotechnology
  • Computer Science(all)

Cite this

Delafield-Butt, J. T., Pepping, G. J., McCaig, C. D., & Lee, D. N. (2012). Prospective guidance in a free-swimming cell. Biological Cybernetics, 106(4-5), 283-293. https://doi.org/10.1007/s00422-012-0495-5

Prospective guidance in a free-swimming cell. / Delafield-Butt, Jonathan T.; Pepping, Gert Jan; McCaig, Colin D.; Lee, David N.

In: Biological Cybernetics, Vol. 106, No. 4-5, 07.2012, p. 283-293.

Research output: Contribution to journalReview article

Delafield-Butt, JT, Pepping, GJ, McCaig, CD & Lee, DN 2012, 'Prospective guidance in a free-swimming cell' Biological Cybernetics, vol. 106, no. 4-5, pp. 283-293. https://doi.org/10.1007/s00422-012-0495-5
Delafield-Butt, Jonathan T. ; Pepping, Gert Jan ; McCaig, Colin D. ; Lee, David N. / Prospective guidance in a free-swimming cell. In: Biological Cybernetics. 2012 ; Vol. 106, No. 4-5. pp. 283-293.
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