Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

J. W. M. van der Linden*, M. C. Arendrup, Aafje Warris, K. Lagrou, H. Pelloux, P. M. Hauser, E. Chryssanthou, E. Mellado, S. E. Kidd, A. M. Tortorano, E. Dannaoui, P. Gaustad, J. W. Baddley, A. Uekoetter, C. Lass-Floerl, N. Klimko, C. B. Moore, D. W. Denning, A. C. Pasqualotto, C. KibblerS. Arikan-Akdagli, D. Andes, J. Meletiadis, L. Naumiuk, M. Nucci, W. J. G. Melchers, P. E. Verweij

*Corresponding author for this work

Research output: Contribution to journalArticle

176 Citations (Scopus)

Abstract

To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

Original languageEnglish
Pages (from-to)1041-1044
Number of pages4
JournalEmerging Infectious Diseases
Volume21
Issue number6
DOIs
Publication statusPublished - Jun 2015

Keywords

  • Azole resistance
  • Aspergillus fumigatus
  • Aspergillus diseases

Cite this

van der Linden, J. W. M., Arendrup, M. C., Warris, A., Lagrou, K., Pelloux, H., Hauser, P. M., Chryssanthou, E., Mellado, E., Kidd, S. E., Tortorano, A. M., Dannaoui, E., Gaustad, P., Baddley, J. W., Uekoetter, A., Lass-Floerl, C., Klimko, N., Moore, C. B., Denning, D. W., Pasqualotto, A. C., ... Verweij, P. E. (2015). Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus. Emerging Infectious Diseases, 21(6), 1041-1044. https://doi.org/10.3201/eid2106.140717