Prospective Multicenter International Surveillance of Azole Resistance in Aspergillus fumigatus

J. W. M. van der Linden*, M. C. Arendrup, Aafje Warris, K. Lagrou, H. Pelloux, P. M. Hauser, E. Chryssanthou, E. Mellado, S. E. Kidd, A. M. Tortorano, E. Dannaoui, P. Gaustad, J. W. Baddley, A. Uekoetter, C. Lass-Floerl, N. Klimko, C. B. Moore, D. W. Denning, A. C. Pasqualotto, C. KibblerS. Arikan-Akdagli, D. Andes, J. Meletiadis, L. Naumiuk, M. Nucci, W. J. G. Melchers, P. E. Verweij

*Corresponding author for this work

Research output: Contribution to journalArticlepeer-review

252 Citations (Scopus)


To investigate azole resistance in clinical Aspergillus isolates, we conducted prospective multicenter international surveillance. A total of 3,788 Aspergillus isolates were screened in 22 centers from 19 countries. Azole-resistant A. fumigatus was more frequently found (3.2% prevalence) than previously acknowledged, causing resistant invasive and noninvasive aspergillosis and severely compromising clinical use of azoles.

Original languageEnglish
Pages (from-to)1041-1044
Number of pages4
JournalEmerging Infectious Diseases
Issue number6
Publication statusPublished - Jun 2015


  • Azole resistance
  • Aspergillus fumigatus
  • Aspergillus diseases


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