Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases

Stein Kaasa; Elisabeth Brenne; Jo-Asmund Lund; Peter Fayers; Ursula Falkmer; Matts Holmberg; Magnus Lagerlund; Oivind  Bruland

doi:10.1016/j.radonc.2006.05.006

Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases

Stein Kaasa, Elisabeth Brenne, Jo-Asmund Lund, Peter Fayers, Ursula Falkmer, Matts Holmberg, Magnus Lagerlund, Oivind Bruland

Applied Health Sciences

Research output: Contribution to journal › Article › peer-review

134 Citations (Scopus)

Abstract

Abstract
Background and purpose
To investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.

Patients and methods
The study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8 Gy×1) or multiple-fraction (3 Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue and global quality of life as the secondary endpoints.

Results
The data monitoring committee recommended closure of the study after 376 patients had been recruited because interim analyses indicated that, as in two other recently published trials, the treatment groups had similar outcomes. Both groups experienced similar pain relief within the first 4 months, and this was maintained throughout the 28-week follow-up. No differences were found for fatigue and global quality of life. Survival was similar in both groups, with median survival of 8–9 months.

Conclusions
Single-fraction 8 Gy and multiple-fraction radiotherapy provide similar pain benefit. These results, confirming those of other studies, indicate that single-fraction 8 Gy should be standard management policy for these patients.

Original language	English
Pages (from-to)	278-284
Number of pages	7
Journal	Radiotherapy and Oncology
Volume	79
Issue number	3
Early online date	21 Jun 2006
DOIs	https://doi.org/10.1016/j.radonc.2006.05.006
Publication status	Published - Jun 2006

Keywords

bone metastases
radiotherapy
single fraction
QUALITY-OF-LIFE
RADIATION-THERAPY
FOLLOW-UP
MULTIFRACTION RADIOTHERAPY
CANCER PATIENTS
PALLIATION
MANAGEMENT
SCHEDULES
RELIEF

UN SDGs

This output contributes to the following UN Sustainable Development Goals (SDGs)

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10.1016/j.radonc.2006.05.006Licence: Unspecified

Cite this

@article{4f9345268ef744ffa43825bf420bbb60,

title = "Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases",

abstract = "AbstractBackground and purposeTo investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.Patients and methodsThe study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8 Gy×1) or multiple-fraction (3 Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue and global quality of life as the secondary endpoints.ResultsThe data monitoring committee recommended closure of the study after 376 patients had been recruited because interim analyses indicated that, as in two other recently published trials, the treatment groups had similar outcomes. Both groups experienced similar pain relief within the first 4 months, and this was maintained throughout the 28-week follow-up. No differences were found for fatigue and global quality of life. Survival was similar in both groups, with median survival of 8–9 months.ConclusionsSingle-fraction 8 Gy and multiple-fraction radiotherapy provide similar pain benefit. These results, confirming those of other studies, indicate that single-fraction 8 Gy should be standard management policy for these patients.",

keywords = "bone metastases, radiotherapy, single fraction, QUALITY-OF-LIFE, RADIATION-THERAPY, FOLLOW-UP, MULTIFRACTION RADIOTHERAPY, CANCER PATIENTS, PALLIATION, MANAGEMENT, SCHEDULES, RELIEF",

author = "Stein Kaasa and Elisabeth Brenne and Jo-Asmund Lund and Peter Fayers and Ursula Falkmer and Matts Holmberg and Magnus Lagerlund and Oivind Bruland",

note = "Acknowledgements We thank Ingegerd Carlberg, Norrlands Hospital, Umea; Christina Lindemalm, Jan Fagerberg, Ingemar Na¨slund, Radiumhemmet, Karolinska Hospital, Stockholm; Roy Bremnes, Tromso University Hospital, Tromso; Anders Ask, Jacob Engellau, Lunds Hospital, Lund; Steinar Hagen, Ulleval University Hospital, Oslo and Mikael Kalkner, Uppsala University Hospital, Uppsala for recruiting patients to this study.",

year = "2006",

month = jun,

doi = "10.1016/j.radonc.2006.05.006",

language = "English",

volume = "79",

pages = "278--284",

journal = "Radiotherapy and Oncology",

issn = "0167-8140",

publisher = "Elsevier Ireland Ltd",

number = "3",

}

TY - JOUR

T1 - Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases

AU - Kaasa, Stein

AU - Brenne, Elisabeth

AU - Lund, Jo-Asmund

AU - Fayers, Peter

AU - Falkmer, Ursula

AU - Holmberg, Matts

AU - Lagerlund, Magnus

AU - Bruland, Oivind

N1 - Acknowledgements We thank Ingegerd Carlberg, Norrlands Hospital, Umea; Christina Lindemalm, Jan Fagerberg, Ingemar Na¨slund, Radiumhemmet, Karolinska Hospital, Stockholm; Roy Bremnes, Tromso University Hospital, Tromso; Anders Ask, Jacob Engellau, Lunds Hospital, Lund; Steinar Hagen, Ulleval University Hospital, Oslo and Mikael Kalkner, Uppsala University Hospital, Uppsala for recruiting patients to this study.

PY - 2006/6

Y1 - 2006/6

N2 - AbstractBackground and purposeTo investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.Patients and methodsThe study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8 Gy×1) or multiple-fraction (3 Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue and global quality of life as the secondary endpoints.ResultsThe data monitoring committee recommended closure of the study after 376 patients had been recruited because interim analyses indicated that, as in two other recently published trials, the treatment groups had similar outcomes. Both groups experienced similar pain relief within the first 4 months, and this was maintained throughout the 28-week follow-up. No differences were found for fatigue and global quality of life. Survival was similar in both groups, with median survival of 8–9 months.ConclusionsSingle-fraction 8 Gy and multiple-fraction radiotherapy provide similar pain benefit. These results, confirming those of other studies, indicate that single-fraction 8 Gy should be standard management policy for these patients.

AB - AbstractBackground and purposeTo investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.Patients and methodsThe study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8 Gy×1) or multiple-fraction (3 Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue and global quality of life as the secondary endpoints.ResultsThe data monitoring committee recommended closure of the study after 376 patients had been recruited because interim analyses indicated that, as in two other recently published trials, the treatment groups had similar outcomes. Both groups experienced similar pain relief within the first 4 months, and this was maintained throughout the 28-week follow-up. No differences were found for fatigue and global quality of life. Survival was similar in both groups, with median survival of 8–9 months.ConclusionsSingle-fraction 8 Gy and multiple-fraction radiotherapy provide similar pain benefit. These results, confirming those of other studies, indicate that single-fraction 8 Gy should be standard management policy for these patients.

KW - bone metastases

KW - radiotherapy

KW - single fraction

KW - QUALITY-OF-LIFE

KW - RADIATION-THERAPY

KW - FOLLOW-UP

KW - MULTIFRACTION RADIOTHERAPY

KW - CANCER PATIENTS

KW - PALLIATION

KW - MANAGEMENT

KW - SCHEDULES

KW - RELIEF

U2 - 10.1016/j.radonc.2006.05.006

DO - 10.1016/j.radonc.2006.05.006

M3 - Article

VL - 79

SP - 278

EP - 284

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 3

ER -

Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases

Abstract

Keywords

UN SDGs

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