Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases

Stein Kaasa, Elisabeth Brenne, Jo-Asmund Lund, Peter Fayers, Ursula Falkmer, Matts Holmberg, Magnus Lagerlund, Oivind Bruland

Research output: Contribution to journalArticle

116 Citations (Scopus)

Abstract

Abstract
Background and purpose
To investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.

Patients and methods
The study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8 Gy×1) or multiple-fraction (3 Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue and global quality of life as the secondary endpoints.

Results
The data monitoring committee recommended closure of the study after 376 patients had been recruited because interim analyses indicated that, as in two other recently published trials, the treatment groups had similar outcomes. Both groups experienced similar pain relief within the first 4 months, and this was maintained throughout the 28-week follow-up. No differences were found for fatigue and global quality of life. Survival was similar in both groups, with median survival of 8–9 months.

Conclusions
Single-fraction 8 Gy and multiple-fraction radiotherapy provide similar pain benefit. These results, confirming those of other studies, indicate that single-fraction 8 Gy should be standard management policy for these patients.
Original languageEnglish
Pages (from-to)278-284
Number of pages7
JournalRadiotherapy and Oncology
Volume79
Issue number3
Early online date21 Jun 2006
DOIs
Publication statusPublished - Jun 2006

Keywords

  • bone metastases
  • radiotherapy
  • single fraction
  • QUALITY-OF-LIFE
  • RADIATION-THERAPY
  • FOLLOW-UP
  • MULTIFRACTION RADIOTHERAPY
  • CANCER PATIENTS
  • PALLIATION
  • MANAGEMENT
  • SCHEDULES
  • RELIEF

Cite this

Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases. / Kaasa, Stein; Brenne, Elisabeth; Lund, Jo-Asmund; Fayers, Peter; Falkmer, Ursula; Holmberg, Matts; Lagerlund, Magnus; Bruland, Oivind .

In: Radiotherapy and Oncology, Vol. 79, No. 3, 06.2006, p. 278-284.

Research output: Contribution to journalArticle

Kaasa, Stein ; Brenne, Elisabeth ; Lund, Jo-Asmund ; Fayers, Peter ; Falkmer, Ursula ; Holmberg, Matts ; Lagerlund, Magnus ; Bruland, Oivind . / Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases. In: Radiotherapy and Oncology. 2006 ; Vol. 79, No. 3. pp. 278-284.
@article{4f9345268ef744ffa43825bf420bbb60,
title = "Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases",
abstract = "AbstractBackground and purposeTo investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.Patients and methodsThe study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8 Gy×1) or multiple-fraction (3 Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue and global quality of life as the secondary endpoints.ResultsThe data monitoring committee recommended closure of the study after 376 patients had been recruited because interim analyses indicated that, as in two other recently published trials, the treatment groups had similar outcomes. Both groups experienced similar pain relief within the first 4 months, and this was maintained throughout the 28-week follow-up. No differences were found for fatigue and global quality of life. Survival was similar in both groups, with median survival of 8–9 months.ConclusionsSingle-fraction 8 Gy and multiple-fraction radiotherapy provide similar pain benefit. These results, confirming those of other studies, indicate that single-fraction 8 Gy should be standard management policy for these patients.",
keywords = "bone metastases, radiotherapy, single fraction, QUALITY-OF-LIFE, RADIATION-THERAPY, FOLLOW-UP, MULTIFRACTION RADIOTHERAPY, CANCER PATIENTS, PALLIATION, MANAGEMENT, SCHEDULES, RELIEF",
author = "Stein Kaasa and Elisabeth Brenne and Jo-Asmund Lund and Peter Fayers and Ursula Falkmer and Matts Holmberg and Magnus Lagerlund and Oivind Bruland",
note = "Acknowledgements We thank Ingegerd Carlberg, Norrlands Hospital, Umea; Christina Lindemalm, Jan Fagerberg, Ingemar Na¨slund, Radiumhemmet, Karolinska Hospital, Stockholm; Roy Bremnes, Tromso University Hospital, Tromso; Anders Ask, Jacob Engellau, Lunds Hospital, Lund; Steinar Hagen, Ulleval University Hospital, Oslo and Mikael Kalkner, Uppsala University Hospital, Uppsala for recruiting patients to this study.",
year = "2006",
month = "6",
doi = "10.1016/j.radonc.2006.05.006",
language = "English",
volume = "79",
pages = "278--284",
journal = "Radiotherapy and Oncology",
issn = "0167-8140",
publisher = "Elsevier Ireland Ltd",
number = "3",

}

TY - JOUR

T1 - Prospective randomised multicenter trial on single fraction radiotherapy (8Gyx1) versus multiple fractions (3Gyx10) in the treatment of painful bone metastases

AU - Kaasa, Stein

AU - Brenne, Elisabeth

AU - Lund, Jo-Asmund

AU - Fayers, Peter

AU - Falkmer, Ursula

AU - Holmberg, Matts

AU - Lagerlund, Magnus

AU - Bruland, Oivind

N1 - Acknowledgements We thank Ingegerd Carlberg, Norrlands Hospital, Umea; Christina Lindemalm, Jan Fagerberg, Ingemar Na¨slund, Radiumhemmet, Karolinska Hospital, Stockholm; Roy Bremnes, Tromso University Hospital, Tromso; Anders Ask, Jacob Engellau, Lunds Hospital, Lund; Steinar Hagen, Ulleval University Hospital, Oslo and Mikael Kalkner, Uppsala University Hospital, Uppsala for recruiting patients to this study.

PY - 2006/6

Y1 - 2006/6

N2 - AbstractBackground and purposeTo investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.Patients and methodsThe study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8 Gy×1) or multiple-fraction (3 Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue and global quality of life as the secondary endpoints.ResultsThe data monitoring committee recommended closure of the study after 376 patients had been recruited because interim analyses indicated that, as in two other recently published trials, the treatment groups had similar outcomes. Both groups experienced similar pain relief within the first 4 months, and this was maintained throughout the 28-week follow-up. No differences were found for fatigue and global quality of life. Survival was similar in both groups, with median survival of 8–9 months.ConclusionsSingle-fraction 8 Gy and multiple-fraction radiotherapy provide similar pain benefit. These results, confirming those of other studies, indicate that single-fraction 8 Gy should be standard management policy for these patients.

AB - AbstractBackground and purposeTo investigate whether single-fraction radiotherapy is equal to multiple fractions in the treatment of painful metastases.Patients and methodsThe study planned to recruit 1000 patients with painful bone metastases from four Norwegian and six Swedish hospitals. Patients were randomized to single-fraction (8 Gy×1) or multiple-fraction (3 Gy×10) radiotherapy. The primary endpoint of the study was pain relief, with fatigue and global quality of life as the secondary endpoints.ResultsThe data monitoring committee recommended closure of the study after 376 patients had been recruited because interim analyses indicated that, as in two other recently published trials, the treatment groups had similar outcomes. Both groups experienced similar pain relief within the first 4 months, and this was maintained throughout the 28-week follow-up. No differences were found for fatigue and global quality of life. Survival was similar in both groups, with median survival of 8–9 months.ConclusionsSingle-fraction 8 Gy and multiple-fraction radiotherapy provide similar pain benefit. These results, confirming those of other studies, indicate that single-fraction 8 Gy should be standard management policy for these patients.

KW - bone metastases

KW - radiotherapy

KW - single fraction

KW - QUALITY-OF-LIFE

KW - RADIATION-THERAPY

KW - FOLLOW-UP

KW - MULTIFRACTION RADIOTHERAPY

KW - CANCER PATIENTS

KW - PALLIATION

KW - MANAGEMENT

KW - SCHEDULES

KW - RELIEF

U2 - 10.1016/j.radonc.2006.05.006

DO - 10.1016/j.radonc.2006.05.006

M3 - Article

VL - 79

SP - 278

EP - 284

JO - Radiotherapy and Oncology

JF - Radiotherapy and Oncology

SN - 0167-8140

IS - 3

ER -