Prospects of stem cell therapy in osteoarthritis

Sally Roberts, Paul Genever, Andrew McCaskie, Cosimo De Bari

Research output: Contribution to journalArticle

36 Citations (Scopus)

Abstract

Osteoarthritis is a common disorder in which there is not only extensive degeneration but also an aberrant attempt at repair in joints. Stem cell therapy could provide a permanent, biological solution, with all sources of stem cells (embryonic, fetal and adult) showing some degree of potential. Mesenchymal stromal/stem cells, however, appear to be the leading candidates because of their ability to be sourced from many or all joint tissues. They may also modulate the immune response of individuals, in a manner influenced by local factors. This biological behavior of stem cells renders the application of regulatory standardizations challenging in comparison to pharmaceutical therapies. However, this would not be an issue if endogenous stem cells were activated to effect repair of an arthritic joint.
Original languageEnglish
Pages (from-to)351-366
Number of pages16
JournalRegenerative Medicine
Volume6
Issue number3
DOIs
Publication statusPublished - 2011

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Cell- and Tissue-Based Therapy
Stem cells
Osteoarthritis
Stem Cells
Joints
Mesenchymal Stromal Cells
Fetal Stem Cells
Adult Stem Cells
Embryonic Stem Cells
Repair
Arthritis
Drug products
Standardization
Pharmaceutical Preparations
Tissue
Therapeutics

Keywords

  • Humans
  • Joints
  • Osteoarthritis
  • Stem Cell Niche
  • Stem Cell Transplantation
  • Stem Cells

Cite this

Prospects of stem cell therapy in osteoarthritis. / Roberts, Sally; Genever, Paul; McCaskie, Andrew; De Bari, Cosimo.

In: Regenerative Medicine, Vol. 6, No. 3, 2011, p. 351-366.

Research output: Contribution to journalArticle

Roberts, Sally ; Genever, Paul ; McCaskie, Andrew ; De Bari, Cosimo. / Prospects of stem cell therapy in osteoarthritis. In: Regenerative Medicine. 2011 ; Vol. 6, No. 3. pp. 351-366.
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