Protect us from poor-quality medical research

John P.A. Ioannidis, Siladitya Bhattacharya, J. L.H. Evers, Fulco Van Der Veen, Edgardo Somigliana, Christopher L.R. Barratt, Gianluca Bontempi, David T. Baird, Piergiorgio Crosignani*, Paul Devroey, Klaus Diedrich, Roy G. Farquharson, Lynn R. Fraser, Joep P.M. Geraedts, Luca Gianaroli, Carlo La Vecchia, Cristina Magli, Eva Negri, Arne Sunde, Juha S. Tapanainen & 3 others Basil C. Tarlatzis, Andre Van Steirteghem, Anna Veiga

*Corresponding author for this work

Research output: Contribution to journalArticle

9 Citations (Scopus)

Abstract

Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

Original languageEnglish
Pages (from-to)770-776
Number of pages7
JournalHuman Reproduction
Volume33
Issue number5
Early online date29 Mar 2018
DOIs
Publication statusPublished - 31 May 2018

Fingerprint

Biomedical Research
Observational Studies
Meta-Analysis
Randomized Controlled Trials
Research

Keywords

  • equipose
  • medical research
  • meta-analysis
  • P -value
  • randomized clinical trial

ASJC Scopus subject areas

  • Reproductive Medicine
  • Obstetrics and Gynaecology

Cite this

Ioannidis, J. P. A., Bhattacharya, S., Evers, J. L. H., Der Veen, F. V., Somigliana, E., Barratt, C. L. R., ... Veiga, A. (2018). Protect us from poor-quality medical research. Human Reproduction, 33(5), 770-776. https://doi.org/10.1093/humrep/dey056

Protect us from poor-quality medical research. / Ioannidis, John P.A.; Bhattacharya, Siladitya; Evers, J. L.H.; Der Veen, Fulco Van; Somigliana, Edgardo; Barratt, Christopher L.R.; Bontempi, Gianluca; Baird, David T.; Crosignani, Piergiorgio; Devroey, Paul; Diedrich, Klaus; Farquharson, Roy G.; Fraser, Lynn R.; Geraedts, Joep P.M.; Gianaroli, Luca; La Vecchia, Carlo; Magli, Cristina; Negri, Eva; Sunde, Arne; Tapanainen, Juha S.; Tarlatzis, Basil C.; Steirteghem, Andre Van; Veiga, Anna.

In: Human Reproduction, Vol. 33, No. 5, 31.05.2018, p. 770-776.

Research output: Contribution to journalArticle

Ioannidis, JPA, Bhattacharya, S, Evers, JLH, Der Veen, FV, Somigliana, E, Barratt, CLR, Bontempi, G, Baird, DT, Crosignani, P, Devroey, P, Diedrich, K, Farquharson, RG, Fraser, LR, Geraedts, JPM, Gianaroli, L, La Vecchia, C, Magli, C, Negri, E, Sunde, A, Tapanainen, JS, Tarlatzis, BC, Steirteghem, AV & Veiga, A 2018, 'Protect us from poor-quality medical research', Human Reproduction, vol. 33, no. 5, pp. 770-776. https://doi.org/10.1093/humrep/dey056
Ioannidis JPA, Bhattacharya S, Evers JLH, Der Veen FV, Somigliana E, Barratt CLR et al. Protect us from poor-quality medical research. Human Reproduction. 2018 May 31;33(5):770-776. https://doi.org/10.1093/humrep/dey056
Ioannidis, John P.A. ; Bhattacharya, Siladitya ; Evers, J. L.H. ; Der Veen, Fulco Van ; Somigliana, Edgardo ; Barratt, Christopher L.R. ; Bontempi, Gianluca ; Baird, David T. ; Crosignani, Piergiorgio ; Devroey, Paul ; Diedrich, Klaus ; Farquharson, Roy G. ; Fraser, Lynn R. ; Geraedts, Joep P.M. ; Gianaroli, Luca ; La Vecchia, Carlo ; Magli, Cristina ; Negri, Eva ; Sunde, Arne ; Tapanainen, Juha S. ; Tarlatzis, Basil C. ; Steirteghem, Andre Van ; Veiga, Anna. / Protect us from poor-quality medical research. In: Human Reproduction. 2018 ; Vol. 33, No. 5. pp. 770-776.
@article{5b7348fce94046be9903a959318035e2,
title = "Protect us from poor-quality medical research",
abstract = "Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.",
keywords = "equipose, medical research, meta-analysis, P -value, randomized clinical trial",
author = "Ioannidis, {John P.A.} and Siladitya Bhattacharya and Evers, {J. L.H.} and {Der Veen}, {Fulco Van} and Edgardo Somigliana and Barratt, {Christopher L.R.} and Gianluca Bontempi and Baird, {David T.} and Piergiorgio Crosignani and Paul Devroey and Klaus Diedrich and Farquharson, {Roy G.} and Fraser, {Lynn R.} and Geraedts, {Joep P.M.} and Luca Gianaroli and {La Vecchia}, Carlo and Cristina Magli and Eva Negri and Arne Sunde and Tapanainen, {Juha S.} and Tarlatzis, {Basil C.} and Steirteghem, {Andre Van} and Anna Veiga",
year = "2018",
month = "5",
day = "31",
doi = "10.1093/humrep/dey056",
language = "English",
volume = "33",
pages = "770--776",
journal = "Human Reproduction",
issn = "0268-1161",
publisher = "OXFORD UNIV PRESS",
number = "5",

}

TY - JOUR

T1 - Protect us from poor-quality medical research

AU - Ioannidis, John P.A.

AU - Bhattacharya, Siladitya

AU - Evers, J. L.H.

AU - Der Veen, Fulco Van

AU - Somigliana, Edgardo

AU - Barratt, Christopher L.R.

AU - Bontempi, Gianluca

AU - Baird, David T.

AU - Crosignani, Piergiorgio

AU - Devroey, Paul

AU - Diedrich, Klaus

AU - Farquharson, Roy G.

AU - Fraser, Lynn R.

AU - Geraedts, Joep P.M.

AU - Gianaroli, Luca

AU - La Vecchia, Carlo

AU - Magli, Cristina

AU - Negri, Eva

AU - Sunde, Arne

AU - Tapanainen, Juha S.

AU - Tarlatzis, Basil C.

AU - Steirteghem, Andre Van

AU - Veiga, Anna

PY - 2018/5/31

Y1 - 2018/5/31

N2 - Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

AB - Much of the published medical research is apparently flawed, cannot be replicated and/or has limited or no utility. This article presents an overview of the current landscape of biomedical research, identifies problems associated with common study designs and considers potential solutions. Randomized clinical trials, observational studies, systematic reviews and meta-analyses are discussed in terms of their inherent limitations and potential ways of improving their conduct, analysis and reporting. The current emphasis on statistical significance needs to be replaced by sound design, transparency and willingness to share data with a clear commitment towards improving the quality and utility of clinical research.

KW - equipose

KW - medical research

KW - meta-analysis

KW - P -value

KW - randomized clinical trial

UR - http://www.scopus.com/inward/record.url?scp=85046942537&partnerID=8YFLogxK

U2 - 10.1093/humrep/dey056

DO - 10.1093/humrep/dey056

M3 - Article

VL - 33

SP - 770

EP - 776

JO - Human Reproduction

JF - Human Reproduction

SN - 0268-1161

IS - 5

ER -