Protective mechanisms against toxic electrophiles in Escherichia coli

G P Ferguson

Research output: Contribution to journalLiterature review

41 Citations (Scopus)

Abstract

Escherichia coli are exposed to toxic electrophiles from both endogenous and exogenous sources. To survive, E. coli have developed novel protective mechanisms that appear unique to bacteria. In the absence of one of these mechanisms, electrophiles induce rapid killing. Hence it appears that electrophile-protective mechanisms represent novel targets for antibacterial drug research.

Original languageEnglish
Pages (from-to)242-247
Number of pages6
JournalTrends in Microbiology
Volume7
Publication statusPublished - 1999

Keywords

  • METHYLGLYOXAL PRODUCTION
  • POTASSIUM CHANNELS
  • OXIDATIVE-STRESS
  • N-ETHYLMALEIMIDE
  • GLUTATHIONE
  • SURVIVAL
  • CELLS
  • K+
  • DETOXIFICATION
  • ACTIVATION

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