Protein glycosylation in Candida

Hector M Mora-Montes, Patricia Ponce-Noyola, Julio C Villagómez-Castro, Neil A R Gow, Arturo Flores-Carreón, Everardo López-Romero

Research output: Contribution to journalArticle

44 Citations (Scopus)

Abstract

Candidiasis is a significant cause of invasive human mycosis with associated mortality rates that are equivalent to, or worse than, those cited for most cases of bacterial septicemia. As a result, considerable efforts are being made to understand how the fungus invades host cells and to identify new targets for fungal chemotherapy. This has led to an increasing interest in Candida glycobiology, with an emphasis on the identification of enzymes essential for glycoprotein and adhesion metabolism, and the role of N- and O-linked glycans in host recognition and virulence. Here, we refer to studies dealing with the identification and characterization of enzymes such as dolichol phosphate mannose synthase, dolichol phosphate glucose synthase and processing glycosidases and synthesis, structure and recognition of mannans and discuss recent findings in the context of Candida albicans pathogenesis.
Original languageEnglish
Pages (from-to)1167-1183
Number of pages17
JournalFuture Microbiology
Volume4
Issue number9
DOIs
Publication statusPublished - Nov 2009

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Glycosylation
Candida
Dolichol Phosphates
Glycomics
Mannans
Candidiasis
Glycoside Hydrolases
Enzymes
Candida albicans
Polysaccharides
Virulence
Sepsis
Glycoproteins
Fungi
Glucose
Drug Therapy
Mortality
dolichyl-phosphate beta-D-mannosyltransferase
Invasive Fungal Infections

Keywords

  • candida
  • candidiasis
  • cell adhesion
  • glycosylation
  • host-pathogen interactions
  • humans
  • transferases
  • virulence

Cite this

Mora-Montes, H. M., Ponce-Noyola, P., Villagómez-Castro, J. C., Gow, N. A. R., Flores-Carreón, A., & López-Romero, E. (2009). Protein glycosylation in Candida. Future Microbiology, 4(9), 1167-1183. https://doi.org/10.2217/fmb.09.88

Protein glycosylation in Candida. / Mora-Montes, Hector M; Ponce-Noyola, Patricia; Villagómez-Castro, Julio C; Gow, Neil A R; Flores-Carreón, Arturo; López-Romero, Everardo.

In: Future Microbiology, Vol. 4, No. 9, 11.2009, p. 1167-1183.

Research output: Contribution to journalArticle

Mora-Montes, HM, Ponce-Noyola, P, Villagómez-Castro, JC, Gow, NAR, Flores-Carreón, A & López-Romero, E 2009, 'Protein glycosylation in Candida', Future Microbiology, vol. 4, no. 9, pp. 1167-1183. https://doi.org/10.2217/fmb.09.88
Mora-Montes HM, Ponce-Noyola P, Villagómez-Castro JC, Gow NAR, Flores-Carreón A, López-Romero E. Protein glycosylation in Candida. Future Microbiology. 2009 Nov;4(9):1167-1183. https://doi.org/10.2217/fmb.09.88
Mora-Montes, Hector M ; Ponce-Noyola, Patricia ; Villagómez-Castro, Julio C ; Gow, Neil A R ; Flores-Carreón, Arturo ; López-Romero, Everardo. / Protein glycosylation in Candida. In: Future Microbiology. 2009 ; Vol. 4, No. 9. pp. 1167-1183.
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