Protein turnover rates in sick, premature neonates during the first few days of life

S G Mitton, Alexander Graham Calder, P J Garlick

    Research output: Contribution to journalArticle

    43 Citations (Scopus)

    Abstract

    Rates of protein turnover were measured in 19 infants during the first few days of life while they were receiving i.v. glucose. The technique consisted of a continuous i.v. infusion of L-[1-13C]leucine to measure whole body leucine flux and determination of total urinary nitrogen excretion to assess leucine oxidation rates. Subsequent to each of the studies, the decision to start total parenteral nutrition (TPN) was made by the clinician concerned, with the result that seven infants did not start TPN and 12 did. There were significantly greater urinary nitrogen excretion (p less than 0.001) and lower rates of whole body protein synthesis (p = 0.024) and breakdown (p = 0.015) in those who did start TPN compared with those who did not. The marked difference in nitrogen excretion between the two groups suggests that this could be a useful determinant for deciding which neonate should start TPN.
    Original languageEnglish
    Pages (from-to)418-422
    Number of pages5
    JournalPediatric Research
    Volume30
    Issue number5
    Publication statusPublished - 1 Nov 1991

    Fingerprint

    Total Parenteral Nutrition
    Leucine
    Newborn Infant
    Nitrogen
    Proteins
    Body Weights and Measures
    Glucose

    Keywords

    • Carbon Isotopes
    • Humans
    • Infant Nutritional Physiological Phenomena
    • Infant, Low Birth Weight
    • Infant, Newborn
    • Infant, Premature
    • Leucine
    • Male
    • Nitrogen
    • Nutritional Requirements
    • Parenteral Nutrition, Total
    • Proteins

    Cite this

    Mitton, S. G., Calder, A. G., & Garlick, P. J. (1991). Protein turnover rates in sick, premature neonates during the first few days of life. Pediatric Research, 30(5), 418-422.

    Protein turnover rates in sick, premature neonates during the first few days of life. / Mitton, S G; Calder, Alexander Graham; Garlick, P J.

    In: Pediatric Research, Vol. 30, No. 5, 01.11.1991, p. 418-422.

    Research output: Contribution to journalArticle

    Mitton, SG, Calder, AG & Garlick, PJ 1991, 'Protein turnover rates in sick, premature neonates during the first few days of life', Pediatric Research, vol. 30, no. 5, pp. 418-422.
    Mitton, S G ; Calder, Alexander Graham ; Garlick, P J. / Protein turnover rates in sick, premature neonates during the first few days of life. In: Pediatric Research. 1991 ; Vol. 30, No. 5. pp. 418-422.
    @article{2568c3adba04429cac095c1c273eed2d,
    title = "Protein turnover rates in sick, premature neonates during the first few days of life",
    abstract = "Rates of protein turnover were measured in 19 infants during the first few days of life while they were receiving i.v. glucose. The technique consisted of a continuous i.v. infusion of L-[1-13C]leucine to measure whole body leucine flux and determination of total urinary nitrogen excretion to assess leucine oxidation rates. Subsequent to each of the studies, the decision to start total parenteral nutrition (TPN) was made by the clinician concerned, with the result that seven infants did not start TPN and 12 did. There were significantly greater urinary nitrogen excretion (p less than 0.001) and lower rates of whole body protein synthesis (p = 0.024) and breakdown (p = 0.015) in those who did start TPN compared with those who did not. The marked difference in nitrogen excretion between the two groups suggests that this could be a useful determinant for deciding which neonate should start TPN.",
    keywords = "Carbon Isotopes, Humans, Infant Nutritional Physiological Phenomena, Infant, Low Birth Weight, Infant, Newborn, Infant, Premature, Leucine, Male, Nitrogen, Nutritional Requirements, Parenteral Nutrition, Total, Proteins",
    author = "Mitton, {S G} and Calder, {Alexander Graham} and Garlick, {P J}",
    year = "1991",
    month = "11",
    day = "1",
    language = "English",
    volume = "30",
    pages = "418--422",
    journal = "Pediatric Research",
    issn = "0031-3998",
    publisher = "Lippincott Williams and Wilkins",
    number = "5",

    }

    TY - JOUR

    T1 - Protein turnover rates in sick, premature neonates during the first few days of life

    AU - Mitton, S G

    AU - Calder, Alexander Graham

    AU - Garlick, P J

    PY - 1991/11/1

    Y1 - 1991/11/1

    N2 - Rates of protein turnover were measured in 19 infants during the first few days of life while they were receiving i.v. glucose. The technique consisted of a continuous i.v. infusion of L-[1-13C]leucine to measure whole body leucine flux and determination of total urinary nitrogen excretion to assess leucine oxidation rates. Subsequent to each of the studies, the decision to start total parenteral nutrition (TPN) was made by the clinician concerned, with the result that seven infants did not start TPN and 12 did. There were significantly greater urinary nitrogen excretion (p less than 0.001) and lower rates of whole body protein synthesis (p = 0.024) and breakdown (p = 0.015) in those who did start TPN compared with those who did not. The marked difference in nitrogen excretion between the two groups suggests that this could be a useful determinant for deciding which neonate should start TPN.

    AB - Rates of protein turnover were measured in 19 infants during the first few days of life while they were receiving i.v. glucose. The technique consisted of a continuous i.v. infusion of L-[1-13C]leucine to measure whole body leucine flux and determination of total urinary nitrogen excretion to assess leucine oxidation rates. Subsequent to each of the studies, the decision to start total parenteral nutrition (TPN) was made by the clinician concerned, with the result that seven infants did not start TPN and 12 did. There were significantly greater urinary nitrogen excretion (p less than 0.001) and lower rates of whole body protein synthesis (p = 0.024) and breakdown (p = 0.015) in those who did start TPN compared with those who did not. The marked difference in nitrogen excretion between the two groups suggests that this could be a useful determinant for deciding which neonate should start TPN.

    KW - Carbon Isotopes

    KW - Humans

    KW - Infant Nutritional Physiological Phenomena

    KW - Infant, Low Birth Weight

    KW - Infant, Newborn

    KW - Infant, Premature

    KW - Leucine

    KW - Male

    KW - Nitrogen

    KW - Nutritional Requirements

    KW - Parenteral Nutrition, Total

    KW - Proteins

    M3 - Article

    VL - 30

    SP - 418

    EP - 422

    JO - Pediatric Research

    JF - Pediatric Research

    SN - 0031-3998

    IS - 5

    ER -