Proteomic analysis of human plasma and blood cells in nutritional studies: development of biomarkers to aid disease prevention

    Research output: Contribution to journalArticle

    21 Citations (Scopus)

    Abstract

    Proteomics is emerging as a valuable tool in nutritional research. Proteome analysis from plasma and blood cells can identify thousands of proteins that can potentially provide valuable new biomarkers for health, reveal early indications for disease disposition, assist in dietary responders from nonresponders, and enable the discovery of mechanisms of beneficial food component effects. This review discusses the latest developments in plasma, platelet and peripheral blood mononuclear cell proteomics, specifically in the field of nutritional proteomics, including issues relating to study design, sample preparation and data interpretation.
    Original languageEnglish
    Pages (from-to)819-826
    Number of pages8
    JournalExpert Review of Proteomics
    Volume5
    Issue number6
    DOIs
    Publication statusPublished - 1 Dec 2008

    Fingerprint

    Plasma (human)
    Biomarkers
    Plasma Cells
    Proteomics
    Blood Cells
    Blood
    Cells
    Plasmas
    Proteome
    Platelets
    Blood Platelets
    Health
    Food
    Research
    Proteins

    Keywords

    • animals
    • biological markers
    • blood cells
    • diet
    • disease
    • humans
    • plasma
    • proteomics
    • nutritional studies
    • peripheral blood mononuclear cell
    • platelet
    • study design

    Cite this

    @article{29dfa52ee9bf4452b662f78d52f6f497,
    title = "Proteomic analysis of human plasma and blood cells in nutritional studies: development of biomarkers to aid disease prevention",
    abstract = "Proteomics is emerging as a valuable tool in nutritional research. Proteome analysis from plasma and blood cells can identify thousands of proteins that can potentially provide valuable new biomarkers for health, reveal early indications for disease disposition, assist in dietary responders from nonresponders, and enable the discovery of mechanisms of beneficial food component effects. This review discusses the latest developments in plasma, platelet and peripheral blood mononuclear cell proteomics, specifically in the field of nutritional proteomics, including issues relating to study design, sample preparation and data interpretation.",
    keywords = "animals, biological markers, blood cells, diet, disease, humans, plasma, proteomics, nutritional studies, peripheral blood mononuclear cell, platelet , study design",
    author = "{De Roos}, Baukje",
    year = "2008",
    month = "12",
    day = "1",
    doi = "10.1586/14789450.5.6.819",
    language = "English",
    volume = "5",
    pages = "819--826",
    journal = "Expert Review of Proteomics",
    issn = "1478-9450",
    publisher = "TAYLOR & FRANCIS LTD",
    number = "6",

    }

    TY - JOUR

    T1 - Proteomic analysis of human plasma and blood cells in nutritional studies

    T2 - development of biomarkers to aid disease prevention

    AU - De Roos, Baukje

    PY - 2008/12/1

    Y1 - 2008/12/1

    N2 - Proteomics is emerging as a valuable tool in nutritional research. Proteome analysis from plasma and blood cells can identify thousands of proteins that can potentially provide valuable new biomarkers for health, reveal early indications for disease disposition, assist in dietary responders from nonresponders, and enable the discovery of mechanisms of beneficial food component effects. This review discusses the latest developments in plasma, platelet and peripheral blood mononuclear cell proteomics, specifically in the field of nutritional proteomics, including issues relating to study design, sample preparation and data interpretation.

    AB - Proteomics is emerging as a valuable tool in nutritional research. Proteome analysis from plasma and blood cells can identify thousands of proteins that can potentially provide valuable new biomarkers for health, reveal early indications for disease disposition, assist in dietary responders from nonresponders, and enable the discovery of mechanisms of beneficial food component effects. This review discusses the latest developments in plasma, platelet and peripheral blood mononuclear cell proteomics, specifically in the field of nutritional proteomics, including issues relating to study design, sample preparation and data interpretation.

    KW - animals

    KW - biological markers

    KW - blood cells

    KW - diet

    KW - disease

    KW - humans

    KW - plasma

    KW - proteomics

    KW - nutritional studies

    KW - peripheral blood mononuclear cell

    KW - platelet

    KW - study design

    U2 - 10.1586/14789450.5.6.819

    DO - 10.1586/14789450.5.6.819

    M3 - Article

    VL - 5

    SP - 819

    EP - 826

    JO - Expert Review of Proteomics

    JF - Expert Review of Proteomics

    SN - 1478-9450

    IS - 6

    ER -