Proteomics for early detection of colorectal cancer: recent updates

Abdo Alnabulsi, Graeme I. Murray*

*Corresponding author for this work

Research output: Contribution to journalReview article

6 Citations (Scopus)
5 Downloads (Pure)

Abstract

Introduction: Colorectal cancer (CRC) is a common type of cancer with a relatively poor survival rate. The survival rate of patients could be improved if CRC is detected early. Biomarkers associated with early stages of tumour development might provide useful tools for the early diagnosis of colorectal cancer.

Area covered: Online searches using PubMed and Google Scholar were performed using keywords and with a focus on recent proteomic studies. The aim of this review is to highlight the need for biomarkers to improve the detection rate of early CRC and provide an overview of proteomic technologies used for biomarker discovery and validation. This review will also discuss recent proteomic studies which focus on identifying biomarkers associated with the early stages of CRC development.

Expert opinion: A large number of CRC biomarkers are increasingly being identified by proteomics using diverse approaches. However, the clinical relevance and introduction of these markers into clinical practice cannot be determined without a robust validation process. The size of validation cohorts remains a major limitation in many biomarker studies.
Original languageEnglish
Pages (from-to)55-63
Number of pages9
JournalExpert Review of Proteomics
Volume15
Issue number1
Early online date6 Nov 2017
DOIs
Publication statusPublished - 2018

Fingerprint

Biomarkers
Early Detection of Cancer
Proteomics
Colorectal Neoplasms
Survival Rate
Tumor Biomarkers
Expert Testimony
Tumors
PubMed
Neoplasms
Technology

Keywords

  • Biomarker
  • colorectal cancer
  • diagnosis
  • early detection
  • proteomics
  • screening
  • FECAL IMMUNOCHEMICAL TEST
  • URINARY PGE-M
  • BIOMARKER DISCOVERY
  • MASS-SPECTROMETRY
  • CLINICAL IMPACT
  • BLOOD-TEST
  • MISS RATE
  • ADENOMAS
  • PROTEINS
  • PROGRESSION

Cite this

Proteomics for early detection of colorectal cancer : recent updates. / Alnabulsi, Abdo; Murray, Graeme I.

In: Expert Review of Proteomics, Vol. 15, No. 1, 2018, p. 55-63.

Research output: Contribution to journalReview article

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title = "Proteomics for early detection of colorectal cancer: recent updates",
abstract = "Introduction: Colorectal cancer (CRC) is a common type of cancer with a relatively poor survival rate. The survival rate of patients could be improved if CRC is detected early. Biomarkers associated with early stages of tumour development might provide useful tools for the early diagnosis of colorectal cancer.Area covered: Online searches using PubMed and Google Scholar were performed using keywords and with a focus on recent proteomic studies. The aim of this review is to highlight the need for biomarkers to improve the detection rate of early CRC and provide an overview of proteomic technologies used for biomarker discovery and validation. This review will also discuss recent proteomic studies which focus on identifying biomarkers associated with the early stages of CRC development.Expert opinion: A large number of CRC biomarkers are increasingly being identified by proteomics using diverse approaches. However, the clinical relevance and introduction of these markers into clinical practice cannot be determined without a robust validation process. The size of validation cohorts remains a major limitation in many biomarker studies.",
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author = "Abdo Alnabulsi and Murray, {Graeme I.}",
note = "Funding: This manuscript was not funded.",
year = "2018",
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journal = "Expert Review of Proteomics",
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T1 - Proteomics for early detection of colorectal cancer

T2 - recent updates

AU - Alnabulsi, Abdo

AU - Murray, Graeme I.

N1 - Funding: This manuscript was not funded.

PY - 2018

Y1 - 2018

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AB - Introduction: Colorectal cancer (CRC) is a common type of cancer with a relatively poor survival rate. The survival rate of patients could be improved if CRC is detected early. Biomarkers associated with early stages of tumour development might provide useful tools for the early diagnosis of colorectal cancer.Area covered: Online searches using PubMed and Google Scholar were performed using keywords and with a focus on recent proteomic studies. The aim of this review is to highlight the need for biomarkers to improve the detection rate of early CRC and provide an overview of proteomic technologies used for biomarker discovery and validation. This review will also discuss recent proteomic studies which focus on identifying biomarkers associated with the early stages of CRC development.Expert opinion: A large number of CRC biomarkers are increasingly being identified by proteomics using diverse approaches. However, the clinical relevance and introduction of these markers into clinical practice cannot be determined without a robust validation process. The size of validation cohorts remains a major limitation in many biomarker studies.

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KW - URINARY PGE-M

KW - BIOMARKER DISCOVERY

KW - MASS-SPECTROMETRY

KW - CLINICAL IMPACT

KW - BLOOD-TEST

KW - MISS RATE

KW - ADENOMAS

KW - PROTEINS

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