Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis

Jenna Gregory; F. M. Waldron; T. Soane; L. Fulton; D. Leighton; Jeremy  Chataway; S. Pal; S. Chandran; Malcolm R. Macleod

doi:10.1002/ebm2.23

Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis

Jenna Gregory, F. M. Waldron, T. Soane, L. Fulton, D. Leighton, Jeremy Chataway, S. Pal, S. Chandran, Malcolm R. Macleod

Medical Sciences

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Abstract

Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no cure and limited treatment options. There is therefore an urgent need for effective therapeutic interventions in this disease. This protocol outlines the strategy for a systematic review and meta-analysis to identify, from in vivo animal and human induced pluripotent stem cell (hiPSC) studies, potential therapeutic interventions for ALS. Our aim is to perform a comprehensive review of the ALS literature to compile a list of (1) candidate interventions and (2) target pathways that may be of therapeutic benefit in patients with ALS.

Original language	English
Pages (from-to)	17-19
Journal	Evidence-based Preclinical Medicine
Volume	3
Issue number	2
DOIs	https://doi.org/10.1002/ebm2.23 https://doi.org/10.1002/ebm2.23
Publication status	Published - Dec 2016

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10.1002/ebm2.23Licence: CC BY

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title = "Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis",

abstract = "Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no cure and limited treatment options. There is therefore an urgent need for effective therapeutic interventions in this disease. This protocol outlines the strategy for a systematic review and meta-analysis to identify, from in vivo animal and human induced pluripotent stem cell (hiPSC) studies, potential therapeutic interventions for ALS. Our aim is to perform a comprehensive review of the ALS literature to compile a list of (1) candidate interventions and (2) target pathways that may be of therapeutic benefit in patients with ALS.",

author = "Jenna Gregory and Waldron, {F. M.} and T. Soane and L. Fulton and D. Leighton and Jeremy Chataway and S. Pal and S. Chandran and Macleod, {Malcolm R.}",

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AU - Gregory, Jenna

AU - Waldron, F. M.

AU - Soane, T.

AU - Fulton, L.

AU - Leighton, D.

AU - Chataway, Jeremy

AU - Pal, S.

AU - Chandran, S.

AU - Macleod, Malcolm R.

PY - 2016/12

Y1 - 2016/12

N2 - Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no cure and limited treatment options. There is therefore an urgent need for effective therapeutic interventions in this disease. This protocol outlines the strategy for a systematic review and meta-analysis to identify, from in vivo animal and human induced pluripotent stem cell (hiPSC) studies, potential therapeutic interventions for ALS. Our aim is to perform a comprehensive review of the ALS literature to compile a list of (1) candidate interventions and (2) target pathways that may be of therapeutic benefit in patients with ALS.

AB - Amyotrophic lateral sclerosis (ALS) is a rapidly progressive neurodegenerative disease with no cure and limited treatment options. There is therefore an urgent need for effective therapeutic interventions in this disease. This protocol outlines the strategy for a systematic review and meta-analysis to identify, from in vivo animal and human induced pluripotent stem cell (hiPSC) studies, potential therapeutic interventions for ALS. Our aim is to perform a comprehensive review of the ALS literature to compile a list of (1) candidate interventions and (2) target pathways that may be of therapeutic benefit in patients with ALS.

UR - https://onlinelibrary.wiley.com/doi/10.1002/ebm2.23

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JO - Evidence-based Preclinical Medicine

JF - Evidence-based Preclinical Medicine

IS - 2

ER -

Protocol for a systematic review and meta-analysis of experimental models of amyotrophic lateral sclerosis

Abstract

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