Protocol for the CHEST Australia Trial

a phase II randomised controlled trial of an intervention to reduce time-to-consult with symptoms of lung cancer

Sonya R Murray, Peter Murchie, Neil Campbell, Fiona M Walter, Danielle Mazza, Emily Habgood, Yvonne Kutzer, Andrew Martin, Stephen Goodall, David J Barnes, Jon D Emery

Research output: Contribution to journalArticle

10 Citations (Scopus)
6 Downloads (Pure)

Abstract

Lung cancer is the most common cancer worldwide, with 1.3 million new cases diagnosed every year. It has one of the lowest survival outcomes of any cancer because over two-thirds of patients are diagnosed when curative treatment is not possible. International research has focused on screening and community interventions to promote earlier presentation to a healthcare provider to improve early lung cancer detection. This paper describes the protocol for a phase II, multisite, randomised controlled trial, for patients at increased risk of lung cancer in the primary care setting, to facilitate early presentation with symptoms of lung cancer.

Methods/analysis The intervention is based on a previous Scottish CHEST Trial that comprised of a primary-care nurse consultation to discuss and implement a self-help manual, followed by self-monitoring reminders to improve symptom appraisal and encourage help-seeking in patients at increased risk of lung cancer. We aim to recruit 550 patients from two Australian states: Western Australia and Victoria. Patients will be randomised to the Intervention (a health consultation involving a self-help manual, monthly prompts and spirometry) or Control (spirometry followed by usual care). Eligible participants are long-term smokers with at least 20 pack years, aged 55 and over, including ex-smokers if their cessation date was less than 15 years ago. The primary outcome is consultation rate for respiratory symptoms.

Ethics and dissemination Ethical approval has been obtained from The University of Western Australia's Human Research Ethics Committee (RA/4/1/6018) and The University of Melbourne Human Research Committee (1 441 433). A summary of the results will be disseminated to participants and we plan to publish the main trial outcomes in a single paper. Further publications are anticipated after further data analysis. Findings will be presented at national and international conferences from late 2016.
Original languageEnglish
Article numbere008046
Number of pages7
JournalBMJ Open
Volume5
Issue number5
DOIs
Publication statusPublished - 18 May 2015

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Lung Neoplasms
Randomized Controlled Trials
Western Australia
Referral and Consultation
Spirometry
Primary Health Care
Victoria
Research Ethics Committees
Respiratory Rate
Early Detection of Cancer
Research
Ethics
Health Personnel
Publications
Neoplasms
Nurses
Survival
Health
Therapeutics

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Protocol for the CHEST Australia Trial : a phase II randomised controlled trial of an intervention to reduce time-to-consult with symptoms of lung cancer. / Murray, Sonya R; Murchie, Peter; Campbell, Neil; Walter, Fiona M; Mazza, Danielle; Habgood, Emily; Kutzer, Yvonne; Martin, Andrew; Goodall, Stephen; Barnes, David J; Emery, Jon D.

In: BMJ Open, Vol. 5, No. 5, e008046, 18.05.2015.

Research output: Contribution to journalArticle

Murray, SR, Murchie, P, Campbell, N, Walter, FM, Mazza, D, Habgood, E, Kutzer, Y, Martin, A, Goodall, S, Barnes, DJ & Emery, JD 2015, 'Protocol for the CHEST Australia Trial: a phase II randomised controlled trial of an intervention to reduce time-to-consult with symptoms of lung cancer', BMJ Open, vol. 5, no. 5, e008046. https://doi.org/10.1136/bmjopen-2015-008046
Murray, Sonya R ; Murchie, Peter ; Campbell, Neil ; Walter, Fiona M ; Mazza, Danielle ; Habgood, Emily ; Kutzer, Yvonne ; Martin, Andrew ; Goodall, Stephen ; Barnes, David J ; Emery, Jon D. / Protocol for the CHEST Australia Trial : a phase II randomised controlled trial of an intervention to reduce time-to-consult with symptoms of lung cancer. In: BMJ Open. 2015 ; Vol. 5, No. 5.
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abstract = "Lung cancer is the most common cancer worldwide, with 1.3 million new cases diagnosed every year. It has one of the lowest survival outcomes of any cancer because over two-thirds of patients are diagnosed when curative treatment is not possible. International research has focused on screening and community interventions to promote earlier presentation to a healthcare provider to improve early lung cancer detection. This paper describes the protocol for a phase II, multisite, randomised controlled trial, for patients at increased risk of lung cancer in the primary care setting, to facilitate early presentation with symptoms of lung cancer. Methods/analysis The intervention is based on a previous Scottish CHEST Trial that comprised of a primary-care nurse consultation to discuss and implement a self-help manual, followed by self-monitoring reminders to improve symptom appraisal and encourage help-seeking in patients at increased risk of lung cancer. We aim to recruit 550 patients from two Australian states: Western Australia and Victoria. Patients will be randomised to the Intervention (a health consultation involving a self-help manual, monthly prompts and spirometry) or Control (spirometry followed by usual care). Eligible participants are long-term smokers with at least 20 pack years, aged 55 and over, including ex-smokers if their cessation date was less than 15 years ago. The primary outcome is consultation rate for respiratory symptoms. Ethics and dissemination Ethical approval has been obtained from The University of Western Australia's Human Research Ethics Committee (RA/4/1/6018) and The University of Melbourne Human Research Committee (1 441 433). A summary of the results will be disseminated to participants and we plan to publish the main trial outcomes in a single paper. Further publications are anticipated after further data analysis. Findings will be presented at national and international conferences from late 2016.",
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AU - Habgood, Emily

AU - Kutzer, Yvonne

AU - Martin, Andrew

AU - Goodall, Stephen

AU - Barnes, David J

AU - Emery, Jon D

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N2 - Lung cancer is the most common cancer worldwide, with 1.3 million new cases diagnosed every year. It has one of the lowest survival outcomes of any cancer because over two-thirds of patients are diagnosed when curative treatment is not possible. International research has focused on screening and community interventions to promote earlier presentation to a healthcare provider to improve early lung cancer detection. This paper describes the protocol for a phase II, multisite, randomised controlled trial, for patients at increased risk of lung cancer in the primary care setting, to facilitate early presentation with symptoms of lung cancer. Methods/analysis The intervention is based on a previous Scottish CHEST Trial that comprised of a primary-care nurse consultation to discuss and implement a self-help manual, followed by self-monitoring reminders to improve symptom appraisal and encourage help-seeking in patients at increased risk of lung cancer. We aim to recruit 550 patients from two Australian states: Western Australia and Victoria. Patients will be randomised to the Intervention (a health consultation involving a self-help manual, monthly prompts and spirometry) or Control (spirometry followed by usual care). Eligible participants are long-term smokers with at least 20 pack years, aged 55 and over, including ex-smokers if their cessation date was less than 15 years ago. The primary outcome is consultation rate for respiratory symptoms. Ethics and dissemination Ethical approval has been obtained from The University of Western Australia's Human Research Ethics Committee (RA/4/1/6018) and The University of Melbourne Human Research Committee (1 441 433). A summary of the results will be disseminated to participants and we plan to publish the main trial outcomes in a single paper. Further publications are anticipated after further data analysis. Findings will be presented at national and international conferences from late 2016.

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