Psammaplin A, a chitinase inhibitor isolated from the Fijian marine sponge Aplysinella rhax

J. N. Tabudravu, V. G.H. Eijsink, G. W. Gooday, M. Jaspars*, D. Komander, M. Legg, B. Synstad, D. M.F. Van Aalten

*Corresponding author for this work

Research output: Contribution to journalArticle

87 Citations (Scopus)

Abstract

Several brominated tyrosine derived compounds, psammaplins A (1), K (2) and (3) as well as bisaprasin (4) were isolated from the Fijian marine sponge Aplysinella rhax during a bioassay guided isolation protocol. Their structures were determined using NMR and MS techniques. Psammaplin A was found to moderately inhibit chitinase B from Serratia marcescens, the mode of inhibition being non-competitive. Crystallographic studies suggest that a disordered psammaplin A molecule is bound near the active site. Interestingly, psammaplin A was found to be a potent antifungal agent.

Original languageEnglish
Pages (from-to)1123-1128
Number of pages6
JournalBioorganic and Medicinal Chemistry
Volume10
Issue number4
DOIs
Publication statusPublished - 21 Feb 2002

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