PTP1B in the periphery: regulating insulin sensitivity and ER stress

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Abstract

Protein tyrosine phosphatase 1B (PTP1B) is a major regulator of body mass and insulin sensitivity and plays an important role in signal transduction of many important metabolic pathways such as insulin, leptin, integrin, growth hormone and endoplasmic reticulum (ER) stress response signaling. In this article we review current literature on the divergent role of PTP1B in different tissues in ER stress response signal transduction and its control of insulin sensitivity in vivo. Recent evidence suggests that PTP1B is a direct player in the ER stress response pathway probably due to direct dephosphorylation of PKR-like ER kinase (PERK) on its tyrosine 619 site. Considering that ER stress response pathway is involved in the pathophysiology of insulin and leptin resistance, aging, neurodegenerative disorders, cancer and other diseases, it implicates PTP1B inhibitors as a viable therapeutic target in the treatment and/or prevention of a number of these diseases.
Original languageEnglish
Title of host publicationProtein tyrosine phosphatase control of metabolism
EditorsKendra K. Bence
Place of PublicationLondon
PublisherSpringer
Pages91-105
Number of pages15
ISBN (Electronic)978-1-4614-7855-3
ISBN (Print)978-1-4614-7854-6
DOIs
Publication statusPublished - 2013

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