PTP1B in the periphery

regulating insulin sensitivity and ER stress

Research output: Chapter in Book/Report/Conference proceedingChapter

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Abstract

Protein tyrosine phosphatase 1B (PTP1B) is a major regulator of body mass and insulin sensitivity and plays an important role in signal transduction of many important metabolic pathways such as insulin, leptin, integrin, growth hormone and endoplasmic reticulum (ER) stress response signaling. In this article we review current literature on the divergent role of PTP1B in different tissues in ER stress response signal transduction and its control of insulin sensitivity in vivo. Recent evidence suggests that PTP1B is a direct player in the ER stress response pathway probably due to direct dephosphorylation of PKR-like ER kinase (PERK) on its tyrosine 619 site. Considering that ER stress response pathway is involved in the pathophysiology of insulin and leptin resistance, aging, neurodegenerative disorders, cancer and other diseases, it implicates PTP1B inhibitors as a viable therapeutic target in the treatment and/or prevention of a number of these diseases.
Original languageEnglish
Title of host publicationProtein tyrosine phosphatase control of metabolism
EditorsKendra K. Bence
Place of PublicationLondon
PublisherSpringer
Pages91-105
Number of pages15
ISBN (Electronic)978-1-4614-7855-3
ISBN (Print)978-1-4614-7854-6
DOIs
Publication statusPublished - 2013

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Non-Receptor Type 1 Protein Tyrosine Phosphatase
Endoplasmic Reticulum Stress
Insulin Resistance
Leptin
Signal Transduction
Metabolic Networks and Pathways
Integrins
Endoplasmic Reticulum
Neurodegenerative Diseases
Growth Hormone
Tyrosine
Phosphotransferases
Insulin
Neoplasms

Cite this

Delibegovic, M., & Mody, N. (2013). PTP1B in the periphery: regulating insulin sensitivity and ER stress. In K. K. Bence (Ed.), Protein tyrosine phosphatase control of metabolism (pp. 91-105). London: Springer . https://doi.org/10.1007/978-1-4614-7855-3_5

PTP1B in the periphery : regulating insulin sensitivity and ER stress. / Delibegovic, Mirela; Mody, Nimesh.

Protein tyrosine phosphatase control of metabolism. ed. / Kendra K. Bence. London : Springer , 2013. p. 91-105.

Research output: Chapter in Book/Report/Conference proceedingChapter

Delibegovic, M & Mody, N 2013, PTP1B in the periphery: regulating insulin sensitivity and ER stress. in KK Bence (ed.), Protein tyrosine phosphatase control of metabolism. Springer , London, pp. 91-105. https://doi.org/10.1007/978-1-4614-7855-3_5
Delibegovic M, Mody N. PTP1B in the periphery: regulating insulin sensitivity and ER stress. In Bence KK, editor, Protein tyrosine phosphatase control of metabolism. London: Springer . 2013. p. 91-105 https://doi.org/10.1007/978-1-4614-7855-3_5
Delibegovic, Mirela ; Mody, Nimesh. / PTP1B in the periphery : regulating insulin sensitivity and ER stress. Protein tyrosine phosphatase control of metabolism. editor / Kendra K. Bence. London : Springer , 2013. pp. 91-105
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