Pullularins E and F, two new peptides from the endophytic fungus Bionectria ochroleuca isolated from the mangrove plant Sonneratia caseolaris

Weaam Ebrahim, Julia Kjer, Mustapha El Amrani, Victor Wray, Wenhan Lin, Rainer Ebel, Daowan Lai*, Peter Proksch

*Corresponding author for this work

Research output: Contribution to journalArticle

43 Citations (Scopus)
7 Downloads (Pure)

Abstract

Chemical investigation of the EtOAc extract of the endophytic fungus Bionectria ochroleuca, isolated from the inner leaf tissues of the plant Sonneratia caseolaris (Sonneratiaceae) from Hainan island (China), yielded two new peptides, pullularins E and F (1 and 2) together with three known compounds (3-5). The structures of the new compounds were unambiguously determined on the basis of one- and two-dimensional NMR spectroscopy as well as by high-resolution mass spectrometry. The absolute configurations of amino acids were determined by HPLC analysis of acid hydrolysates using Marfey's method. The isolated compounds exhibited pronounced to moderate cytotoxic activity against the mouse lymphoma cells (L5178Y) with EC50 values ranging between 0.1 and 6.7 μg/mL.

Original languageEnglish
Pages (from-to)1081-1091
Number of pages11
JournalMarine Drugs
Volume10
Issue number5
Early online date18 May 2012
DOIs
Publication statusPublished - 18 May 2012

Keywords

  • Bionectria
  • Endophytes
  • Mangrove plants
  • Marfey's method
  • Peptide
  • Sonneratia
  • Structure elucidation

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