Purealidin S and Purpuramine J, Bromotyrosine Alkaloids from the Fijian Marine Sponge Druinella sp.

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Abstract

Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.

Original languageEnglish
Pages (from-to)1798-1801
Number of pages3
JournalJournal of Natural Products
Volume65
DOIs
Publication statusPublished - 2002

Keywords

  • DIBROMOTYROSINE-DERIVED METABOLITE
  • BROMINATED TYROSINE METABOLITES
  • PSAMMAPLYSILLA-PURPUREA
  • PSEUDOCERATINA-PURPUREA
  • VERONGIDA SPONGES
  • AIOLOCHROIA-CRASSA
  • DERIVATIVES
  • CHEMISTRY
  • CYANOFORMAMIDE
  • CONSTITUENTS

Cite this

@article{6ebd896667204e14948c9de05a43f188,
title = "Purealidin S and Purpuramine J, Bromotyrosine Alkaloids from the Fijian Marine Sponge Druinella sp.",
abstract = "Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.",
keywords = "DIBROMOTYROSINE-DERIVED METABOLITE, BROMINATED TYROSINE METABOLITES, PSAMMAPLYSILLA-PURPUREA, PSEUDOCERATINA-PURPUREA, VERONGIDA SPONGES, AIOLOCHROIA-CRASSA, DERIVATIVES, CHEMISTRY, CYANOFORMAMIDE, CONSTITUENTS",
author = "Tabudravu, {Jioji Natadra} and Marcel Jaspars",
year = "2002",
doi = "10.1021/np020275n",
language = "English",
volume = "65",
pages = "1798--1801",
journal = "Journal of Natural Products",
issn = "0163-3864",
publisher = "American Chemical Society",

}

TY - JOUR

T1 - Purealidin S and Purpuramine J, Bromotyrosine Alkaloids from the Fijian Marine Sponge Druinella sp.

AU - Tabudravu, Jioji Natadra

AU - Jaspars, Marcel

PY - 2002

Y1 - 2002

N2 - Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.

AB - Two bromotyrosine alkaloids, purealidin S (2) and purpuramine J (5), were isolated from the Fijian marine sponge Druinella sp. Eight known bromotyrosine compounds were also isolated. This is the first report of a bromotyrosine N-oxide containing alkaloid. These two compounds were found to have moderate cytotoxic activity. In addition, bioassay data for the eight known bromotyrosine metabolites are reported.

KW - DIBROMOTYROSINE-DERIVED METABOLITE

KW - BROMINATED TYROSINE METABOLITES

KW - PSAMMAPLYSILLA-PURPUREA

KW - PSEUDOCERATINA-PURPUREA

KW - VERONGIDA SPONGES

KW - AIOLOCHROIA-CRASSA

KW - DERIVATIVES

KW - CHEMISTRY

KW - CYANOFORMAMIDE

KW - CONSTITUENTS

U2 - 10.1021/np020275n

DO - 10.1021/np020275n

M3 - Article

VL - 65

SP - 1798

EP - 1801

JO - Journal of Natural Products

JF - Journal of Natural Products

SN - 0163-3864

ER -