Purified Pseudomonas aeruginosa PA-I lectin induces gut growth when orally ingested by rats

George Grant, S BARDOCZ, S.w.b. Ewen, David Stanley Brown, T J DUGUID, A PUSZTAI, D AVICHEZER, D SUDAKEVITZ, A BELZ, N C GARBER, N GILBOAGARBER

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Abstract

The effects of PA-I lectin isolated from the human pathogen Pseudomonas aeruginosa upon cellular metabolism in vivo have been studied using the rat gut as a model system. Orally ingested PA-I lectin stimulated metabolic activity and induced polyamine accumulation and growth in the small intestine, caecum and colon. The nature and extent of the changes induced by PA-I lectin were similar to those caused by dietary kidney bean lectin and were likely to lead to impaired epithelial cell function and integrity. This finding contributes to our understanding of the possible roles of these lectins in Pseudomonas aeruginosa infection.

Original languageEnglish
Pages (from-to)191-195
Number of pages5
JournalFEMS Immunology and Medical Microbiology
Volume11
Issue number3
DOIs
Publication statusPublished - Jun 1995

Keywords

  • pseudomonas aeruginosa
  • lectin
  • gut
  • epithelium
  • rat
  • basolateral polyamine uptake
  • phaseolus-vulgaris
  • splenocytes
  • lymphocytes
  • infection
  • adhesins
  • binding

Cite this

Grant, G., BARDOCZ, S., Ewen, S. W. B., Brown, D. S., DUGUID, T. J., PUSZTAI, A., AVICHEZER, D., SUDAKEVITZ, D., BELZ, A., GARBER, N. C., & GILBOAGARBER, N. (1995). Purified Pseudomonas aeruginosa PA-I lectin induces gut growth when orally ingested by rats. FEMS Immunology and Medical Microbiology, 11(3), 191-195. https://doi.org/10.1016/0928-8244(95)00025-3