Putrescine bisamides from Aglaia gigantea

N.D. Tu; R. Edrada; R. Ebel; V. Wray; W. Frank; T.D. Anh; H.L. Wen; P. Proksch

doi:10.1021/np070184w

Putrescine bisamides from Aglaia gigantea

N.D. Tu, R. Edrada, R. Ebel, V. Wray, W. Frank, T.D. Anh, H.L. Wen, P. Proksch

Chemistry

Research output: Contribution to journal › Article › peer-review

21 Citations (Scopus)

Abstract

Phytochemical analysis of the leaves of Aglaia gigantea collected in Vietnam yielded three cinnamoyl putrescine bisamide derivatives, which included the known compound dasyclamide (1), as well as two new natural products, gigantamide A (2) and grandiamide D (3). In this study, the structure of dasyclamide (1) was confirmed by X-ray crystallography. The structures of the two new alkaloids, gigantamide A (2) and grandiamide D (3), were elucidated through extensive 1D and 2D NMR spectroscopy and analysis of their mass spectrometric (ESIMS, HRQTOFMS) data. The absolute configuration of grandiamide D (3) was determined via Mosher ester derivatization.

Original language	English
Pages (from-to)	1640-1643
Number of pages	4
Journal	Journal of Natural Products
Volume	70
Issue number	10
DOIs	https://doi.org/10.1021/np070184w
Publication status	Published - 1 Oct 2007

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AU - Tu, N.D.

AU - Edrada, R.

AU - Ebel, R.

AU - Wray, V.

AU - Frank, W.

AU - Anh, T.D.

AU - Wen, H.L.

AU - Proksch, P.

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Putrescine bisamides from Aglaia gigantea

Abstract

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