Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.

S.k. Mittal, Benedict Jon Milner, Mark Adrian Vickers

Research output: Contribution to journalArticle

7 Citations (Scopus)

Abstract

The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.

Original languageEnglish
Pages (from-to)402-404
Number of pages2
JournalClinical and Laboratory Haematology
Volume27
DOIs
Publication statusPublished - 2005

Keywords

  • pyoderma gangrenosum
  • gamma and delta T-cell clone
  • sterile abscess
  • splenomegaly and monoclonal gammopathy
  • IGA GAMMOPATHY
  • ANTIPHOSPHOLIPID SYNDROME

Cite this

Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone. / Mittal, S.k.; Milner, Benedict Jon; Vickers, Mark Adrian.

In: Clinical and Laboratory Haematology, Vol. 27, 2005, p. 402-404.

Research output: Contribution to journalArticle

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AB - The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.

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