Abstract
The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.
| Original language | English |
|---|---|
| Pages (from-to) | 402-404 |
| Number of pages | 2 |
| Journal | Clinical and Laboratory Haematology |
| Volume | 27 |
| DOIs | |
| Publication status | Published - 2005 |
Keywords
- pyoderma gangrenosum
- gamma and delta T-cell clone
- sterile abscess
- splenomegaly and monoclonal gammopathy
- IGA GAMMOPATHY
- ANTIPHOSPHOLIPID SYNDROME
Cite this
Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone. / Mittal, S.k.; Milner, Benedict Jon; Vickers, Mark Adrian.
In: Clinical and Laboratory Haematology, Vol. 27, 2005, p. 402-404.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.
AU - Mittal, S.k.
AU - Milner, Benedict Jon
AU - Vickers, Mark Adrian
PY - 2005
Y1 - 2005
N2 - The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.
AB - The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.
KW - pyoderma gangrenosum
KW - gamma and delta T-cell clone
KW - sterile abscess
KW - splenomegaly and monoclonal gammopathy
KW - IGA GAMMOPATHY
KW - ANTIPHOSPHOLIPID SYNDROME
U2 - 10.1111/j.1365-2257.2005.00730.x
DO - 10.1111/j.1365-2257.2005.00730.x
M3 - Article
VL - 27
SP - 402
EP - 404
JO - Clinical and Laboratory Haematology
JF - Clinical and Laboratory Haematology
SN - 0141-9854
ER -