Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.

S.k. Mittal; Benedict Jon Milner; Mark Adrian Vickers

doi:10.1111/j.1365-2257.2005.00730.x

Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone.

S.k. Mittal, Benedict Jon Milner, Mark Adrian Vickers

Research output: Contribution to journal › Article

7 Citations (Scopus)

Abstract

The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.

Original language	English
Pages (from-to)	402-404
Number of pages	2
Journal	Clinical and Laboratory Haematology
Volume	27
DOIs	https://doi.org/10.1111/j.1365-2257.2005.00730.x
Publication status	Published - 2005

Keywords

pyoderma gangrenosum
gamma and delta T-cell clone
sterile abscess
splenomegaly and monoclonal gammopathy
IGA GAMMOPATHY
ANTIPHOSPHOLIPID SYNDROME

Cite this

Mittal, S. K., Milner, B. J., & Vickers, M. A. (2005). Pyoderma gangrenosum as a cause of splenomegaly and association with a T-cell clone. Clinical and Laboratory Haematology, 27, 402-404. https://doi.org/10.1111/j.1365-2257.2005.00730.x

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abstract = "The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.",

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AU - Milner, Benedict Jon

AU - Vickers, Mark Adrian

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Y1 - 2005

N2 - The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.

AB - The spectrum of clinical presentation of haematological disease is wide. We highlight two features of this principle: a rare cause of a 'haematological' presentation and a possible haematological cause of a disease not normally considered as such. A case of systemic pyoderma gangrenosum presented with splenomegaly in the absence of a rash. A clonal gamma- and beta-T-cell receptor rearrangement was demonstrated. Such clones may be a general phenomenon involved in the pathogenesis of this condition.

KW - pyoderma gangrenosum

KW - gamma and delta T-cell clone

KW - sterile abscess

KW - splenomegaly and monoclonal gammopathy

KW - IGA GAMMOPATHY

KW - ANTIPHOSPHOLIPID SYNDROME

U2 - 10.1111/j.1365-2257.2005.00730.x

DO - 10.1111/j.1365-2257.2005.00730.x

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JO - Clinical and Laboratory Haematology

JF - Clinical and Laboratory Haematology

SN - 0141-9854

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10.1111/j.1365-2257.2005.00730.x