In this paper we demonstrate how Morven, a computational framework which can perform qualitative, semi-quantitative, and quantitative simulation of dynamical systems using the same model formalism, is applied to study the osmotic stress response pathway in yeast. First the Morven framework itself is briefly introduced in terms of the model formalism employed and output format. We then built a qualitative model for the biophysical process of the osmoregulation in yeast, and a global qualitative-level picture was obtained through qualitative simulation of this model. Furthermore, we constructed a Morven model based on existing quantitative model of the osmoregulation system. This model was then simulated qualitatively, semi-quantitatively, and quantitatively. The obtained simulation results are presented with an analysis. Finally the future development of the Morven framework for modelling the dynamic biological systems is discussed.
|Number of pages||11|
|Early online date||9 Apr 2015|
|Publication status||Published - May 2015|
- osmotic stress response
- Semi-quantitative simulation
- qualitative simulation
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- School of Natural & Computing Sciences, Computing Science - Emeritus Professor
- Institute for Complex Systems and Mathematical Biology (ICSMB)
Person: Academic, Honorary