Radial glial cells in the adult dentate gyrus: What are they and where do they come from?

Daniel A. Berg, Allison M. Bond, Guo li Ming, Hongjun Song* (Corresponding Author)

*Corresponding author for this work

Research output: Contribution to journalReview article

24 Citations (Scopus)
1 Downloads (Pure)

Abstract

Adult neurogenesis occurs in the dentate gyrus in the mammalian hippocampus. These new neurons arise from neural precursor cells named radial glia-like cells, which are situated in the subgranular zone of the dentate gyrus. Here, we review the emerging topic of precursor heterogeneity in the adult subgranular zone. We also discuss how this heterogeneity may be established during development and focus on the embryonic origin of the dentate gyrus and radial glia-like stem cells. Finally, we discuss recently developed single-cell techniques, which we believe will be critical to comprehensively investigate adult neural stem cell origin and heterogeneity.

Original languageEnglish
Article number277
JournalF1000Research
Volume7
Early online date5 Mar 2018
DOIs
Publication statusPublished - 5 Mar 2018

Keywords

  • Dentate gyrus
  • Radial glial cells
  • Stem cell heterogeneity

ASJC Scopus subject areas

  • Biochemistry, Genetics and Molecular Biology(all)
  • Immunology and Microbiology(all)
  • Pharmacology, Toxicology and Pharmaceutics(all)

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