Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor

Christine A Parker, Roger N Gunn, Eugenii A Rabiner, Mark Slifstein, Robert Comley, Cristian Salinas, Christopher N Johnson, Steen Jakobsen, Sylvain Houle, Marc Laruelle, Vincent J Cunningham, Laurent Martarello

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Abstract

The development of a PET radioligand for imaging 5-hydroxytryptamine (5-HT) 6 receptors in the brain would, for the first time, enable in vivo imaging of this target along with assessment of its involvement in disease pathophysiology. In addition, such a tool would assist in the development of novel drugs targeting the 5-HT6 receptor.
Original languageEnglish
Pages (from-to)295-303
Number of pages9
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume53
Issue number2
Early online date5 Jan 2012
DOIs
Publication statusPublished - 1 Feb 2012

Keywords

  • PET
  • serotonin
  • 5-HT6
  • receptor
  • radioligand

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    Parker, C. A., Gunn, R. N., Rabiner, E. A., Slifstein, M., Comley, R., Salinas, C., Johnson, C. N., Jakobsen, S., Houle, S., Laruelle, M., Cunningham, V. J., & Martarello, L. (2012). Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(2), 295-303. https://doi.org/10.2967/jnumed.111.093419