Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor

Christine A Parker, Roger N Gunn, Eugenii A Rabiner, Mark Slifstein, Robert Comley, Cristian Salinas, Christopher N Johnson, Steen Jakobsen, Sylvain Houle, Marc Laruelle, Vincent J Cunningham, Laurent Martarello

Research output: Contribution to journalArticle

33 Citations (Scopus)

Abstract

The development of a PET radioligand for imaging 5-hydroxytryptamine (5-HT) 6 receptors in the brain would, for the first time, enable in vivo imaging of this target along with assessment of its involvement in disease pathophysiology. In addition, such a tool would assist in the development of novel drugs targeting the 5-HT6 receptor.
Original languageEnglish
Pages (from-to)295-303
Number of pages9
JournalJournal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume53
Issue number2
Early online date5 Jan 2012
DOIs
Publication statusPublished - 1 Feb 2012

Fingerprint

Drug Delivery Systems
Brain
serotonin 6 receptor
GSK215083

Keywords

  • PET
  • serotonin
  • 5-HT6
  • receptor
  • radioligand

Cite this

Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor. / Parker, Christine A; Gunn, Roger N; Rabiner, Eugenii A; Slifstein, Mark; Comley, Robert; Salinas, Cristian; Johnson, Christopher N; Jakobsen, Steen; Houle, Sylvain; Laruelle, Marc; Cunningham, Vincent J; Martarello, Laurent.

In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine, Vol. 53, No. 2, 01.02.2012, p. 295-303.

Research output: Contribution to journalArticle

Parker, CA, Gunn, RN, Rabiner, EA, Slifstein, M, Comley, R, Salinas, C, Johnson, CN, Jakobsen, S, Houle, S, Laruelle, M, Cunningham, VJ & Martarello, L 2012, 'Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 53, no. 2, pp. 295-303. https://doi.org/10.2967/jnumed.111.093419
Parker, Christine A ; Gunn, Roger N ; Rabiner, Eugenii A ; Slifstein, Mark ; Comley, Robert ; Salinas, Cristian ; Johnson, Christopher N ; Jakobsen, Steen ; Houle, Sylvain ; Laruelle, Marc ; Cunningham, Vincent J ; Martarello, Laurent. / Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor. In: Journal of nuclear medicine : official publication, Society of Nuclear Medicine. 2012 ; Vol. 53, No. 2. pp. 295-303.
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