Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor

Christine A Parker; Roger N Gunn; Eugenii A Rabiner; Mark Slifstein; Robert Comley; Cristian Salinas; Christopher N Johnson; Steen Jakobsen; Sylvain Houle; Marc Laruelle; Vincent J Cunningham; Laurent Martarello

doi:10.2967/jnumed.111.093419

Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor

Christine A Parker, Roger N Gunn, Eugenii A Rabiner, Mark Slifstein, Robert Comley, Cristian Salinas, Christopher N Johnson, Steen Jakobsen, Sylvain Houle, Marc Laruelle, Vincent J Cunningham, Laurent Martarello

Applied Medicine

Research output: Contribution to journal › Article › peer-review

50 Citations (Scopus)

Abstract

The development of a PET radioligand for imaging 5-hydroxytryptamine (5-HT) 6 receptors in the brain would, for the first time, enable in vivo imaging of this target along with assessment of its involvement in disease pathophysiology. In addition, such a tool would assist in the development of novel drugs targeting the 5-HT6 receptor.

Original language	English
Pages (from-to)	295-303
Number of pages	9
Journal	Journal of nuclear medicine : official publication, Society of Nuclear Medicine
Volume	53
Issue number	2
Early online date	5 Jan 2012
DOIs	https://doi.org/10.2967/jnumed.111.093419
Publication status	Published - 1 Feb 2012

Keywords

PET
serotonin
5-HT6
receptor
radioligand

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10.2967/jnumed.111.093419

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Parker, C. A., Gunn, R. N., Rabiner, E. A., Slifstein, M., Comley, R., Salinas, C., Johnson, C. N., Jakobsen, S., Houle, S., Laruelle, M., Cunningham, V. J., & Martarello, L. (2012). Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor. Journal of nuclear medicine : official publication, Society of Nuclear Medicine, 53(2), 295-303. https://doi.org/10.2967/jnumed.111.093419

Parker, CA, Gunn, RN, Rabiner, EA, Slifstein, M, Comley, R, Salinas, C, Johnson, CN, Jakobsen, S, Houle, S, Laruelle, M, Cunningham, VJ & Martarello, L 2012, 'Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor', Journal of nuclear medicine : official publication, Society of Nuclear Medicine, vol. 53, no. 2, pp. 295-303. https://doi.org/10.2967/jnumed.111.093419

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AU - Rabiner, Eugenii A

AU - Slifstein, Mark

AU - Comley, Robert

AU - Salinas, Cristian

AU - Johnson, Christopher N

AU - Jakobsen, Steen

AU - Houle, Sylvain

AU - Laruelle, Marc

AU - Cunningham, Vincent J

AU - Martarello, Laurent

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AB - The development of a PET radioligand for imaging 5-hydroxytryptamine (5-HT) 6 receptors in the brain would, for the first time, enable in vivo imaging of this target along with assessment of its involvement in disease pathophysiology. In addition, such a tool would assist in the development of novel drugs targeting the 5-HT6 receptor.

KW - PET

KW - serotonin

KW - 5-HT6

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KW - radioligand

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ER -

Radiosynthesis and Characterization of 11C-GSK215083 as a PET Radioligand for the 5-HT6 Receptor

Abstract

Keywords

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