Radiosynthesis of [N-methyl-C-11]methylene blue

Lutz Frank Schweiger, Stuart A P Craib, Andrew Welch, Peter Frederick Sharp

Research output: Contribution to journalArticle

5 Citations (Scopus)

Abstract

In this paper we present the radiochemical synthesis of the novel compound [N-methyl-C-11]methylene blue. The synthesis of [N-methyl-C-11]methylene blue was accomplished by means of C-11-methylation of commercially available Azure B using [C-11]methyl trifluoromethanesulfonate ([C-11]methyl triflate). Following purification [N-methyl-C-11]methylene blue was obtained with a radiochemical purity greater than 97% in a 4-6% decay corrected radiochemical yield. The synthesis was completed in an average of 35min following the end of bombardment. Copyright (C) 2003 John Wiley Sons, Ltd.

Original languageEnglish
Pages (from-to)1221-1228
Number of pages7
JournalJournal of Labelled Compounds and Radiopharmaceuticals
Volume46
DOIs
Publication statusPublished - 2003

Keywords

  • [N-methyl-C-11]methylene blue
  • [C-11]methyl triflate
  • PET
  • C-11 METHYL TRIFLATE
  • PET RADIOLIGANDS

Cite this

Radiosynthesis of [N-methyl-C-11]methylene blue. / Schweiger, Lutz Frank; Craib, Stuart A P; Welch, Andrew; Sharp, Peter Frederick.

In: Journal of Labelled Compounds and Radiopharmaceuticals, Vol. 46, 2003, p. 1221-1228.

Research output: Contribution to journalArticle

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abstract = "In this paper we present the radiochemical synthesis of the novel compound [N-methyl-C-11]methylene blue. The synthesis of [N-methyl-C-11]methylene blue was accomplished by means of C-11-methylation of commercially available Azure B using [C-11]methyl trifluoromethanesulfonate ([C-11]methyl triflate). Following purification [N-methyl-C-11]methylene blue was obtained with a radiochemical purity greater than 97{\%} in a 4-6{\%} decay corrected radiochemical yield. The synthesis was completed in an average of 35min following the end of bombardment. Copyright (C) 2003 John Wiley Sons, Ltd.",
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AU - Schweiger, Lutz Frank

AU - Craib, Stuart A P

AU - Welch, Andrew

AU - Sharp, Peter Frederick

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N2 - In this paper we present the radiochemical synthesis of the novel compound [N-methyl-C-11]methylene blue. The synthesis of [N-methyl-C-11]methylene blue was accomplished by means of C-11-methylation of commercially available Azure B using [C-11]methyl trifluoromethanesulfonate ([C-11]methyl triflate). Following purification [N-methyl-C-11]methylene blue was obtained with a radiochemical purity greater than 97% in a 4-6% decay corrected radiochemical yield. The synthesis was completed in an average of 35min following the end of bombardment. Copyright (C) 2003 John Wiley Sons, Ltd.

AB - In this paper we present the radiochemical synthesis of the novel compound [N-methyl-C-11]methylene blue. The synthesis of [N-methyl-C-11]methylene blue was accomplished by means of C-11-methylation of commercially available Azure B using [C-11]methyl trifluoromethanesulfonate ([C-11]methyl triflate). Following purification [N-methyl-C-11]methylene blue was obtained with a radiochemical purity greater than 97% in a 4-6% decay corrected radiochemical yield. The synthesis was completed in an average of 35min following the end of bombardment. Copyright (C) 2003 John Wiley Sons, Ltd.

KW - [N-methyl-C-11]methylene blue

KW - [C-11]methyl triflate

KW - PET

KW - C-11 METHYL TRIFLATE

KW - PET RADIOLIGANDS

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JO - Journal of Labelled Compounds and Radiopharmaceuticals

JF - Journal of Labelled Compounds and Radiopharmaceuticals

SN - 0362-4803

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