Abstract
In this paper we present the radiochemical synthesis of the novel compound [N-methyl-C-11]methylene blue. The synthesis of [N-methyl-C-11]methylene blue was accomplished by means of C-11-methylation of commercially available Azure B using [C-11]methyl trifluoromethanesulfonate ([C-11]methyl triflate). Following purification [N-methyl-C-11]methylene blue was obtained with a radiochemical purity greater than 97% in a 4-6% decay corrected radiochemical yield. The synthesis was completed in an average of 35min following the end of bombardment. Copyright (C) 2003 John Wiley Sons, Ltd.
Original language | English |
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Pages (from-to) | 1221-1228 |
Number of pages | 7 |
Journal | Journal of Labelled Compounds and Radiopharmaceuticals |
Volume | 46 |
DOIs | |
Publication status | Published - 2003 |
Keywords
- [N-methyl-C-11]methylene blue
- [C-11]methyl triflate
- PET
- C-11 METHYL TRIFLATE
- PET RADIOLIGANDS