Abstract
Candida auris is a newly emerging pathogenic microbe, having been identified as a medically relevant fungus as recently as 2009. It is the most drug-resistant yeast species known to date and its emergence and population structure are unusual. Because of its recent emergence we are largely ignorant about fundamental aspects of its general biology, life cycle, and population dynamics. Here we report the karyotype variability of 26 C. auris strains representing the four main clades. We demonstrate that all strains are haploid and have a highly plastic karyotype containing five to seven chromosomes, which can undergo marked alterations within a short time-frame when the fungus is put under genotoxic, heat, or osmotic stress. No simple correlation was found between karyotype pattern, drug resistance, and clade affiliation indicating that karyotype heterogeneity is rapidly evolving. As with other Candida species, these marked karyotype differences between isolates are likely to have an important impact on pathogenic traits of C. auris.
Original language | English |
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Pages (from-to) | 1217-1228 |
Number of pages | 12 |
Journal | Current Genetics |
Volume | 65 |
Issue number | 5 |
Early online date | 24 Apr 2019 |
DOIs | |
Publication status | Published - Oct 2019 |
Keywords
- Candida auris
- chromosome number
- chromosome size
- genome size
- rRNA genes
- Genome size
- Chromosome size
- Chromosome number
- Karyotype evolution
- PHENOTYPIC VARIATION
- DE-NOVO
- NUMBER
- INSTABILITY
- MECHANISM
- GENOME
- ANEUPLOIDY
- MUTANTS
- RIBOSOMAL DNA
- ALBICANS
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Iain Fraser Cytometry Centre
Andrea Holme (Manager), Linda Duncan (Senior Application Scientist), Ailsa Laird (Technician) & Kate Burgoyne (Technician)
Institute of Medical SciencesResearch Facilities: Facility