Rapid multi-field T-1 estimation algorithm for Fast Field-Cycling MRI

Research output: Contribution to journalArticle

6 Citations (Scopus)

Abstract

Fast Field-Cycling MRI (FFC-MRI) is an emerging MRI technique that allows the main magnetic field to vary, allowing probing T1 at various magnetic field strengths. This technique offers promising possibilities but requires long scan times to improve the signal-to-noise ratio.
This paper presents an algorithm derived from the two-point method proposed by Edelstein that can estimate T1 using only one image per field, thereby shortening the scan time by a factor of nearly two, taking advantage of the fact that the equilibrium magnetisation is proportional to the magnetic field strength.
Therefore the equilibrium magnetisation only needs measuring once, then T1 can be found from inversion recovery experiments using the Bloch equations. The precision and accuracy of the algorithm are estimated using both simulated and experimental data, by Monte-Carlo simulations and by comparison with standard techniques on a phantom.
The results are acceptable but usage is limited to the case where variations of the main magnetic field are fast compared with T1 and where the dispersion curve is relatively linear. The speed-up of T1 -dispersion measurements resulting from the new method is likely to make FFC-MRI more acceptable when it is applied in the clinic.
Original languageEnglish
Pages (from-to)44-51
Number of pages8
JournalJournal of Magnetic Resonance
Volume238
Early online date31 Oct 2013
DOIs
Publication statusPublished - Jan 2014

Keywords

  • Fast Field-Cycling MRI
  • dispersion curve
  • data processing
  • two-point method algorithm

Cite this

Rapid multi-field T-1 estimation algorithm for Fast Field-Cycling MRI. / Broche, Lionel M.; Ross, Peter James; Pine, Kerrin J.; Lurie, David J.

In: Journal of Magnetic Resonance, Vol. 238, 01.2014, p. 44-51.

Research output: Contribution to journalArticle

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