Rate maintenance and resonance in the entorhinal cortex

Julie S. Haas, Thomas Kreuz, Alessandro Torcini, Antonio Politi, H. D. I. Abarbanel

Research output: Contribution to journalArticle

3 Citations (Scopus)

Abstract

Throughout the brain, neurons encode information in fundamental units of spikes. Each spike represents the combined thresholding of synaptic inputs and intrinsic neuronal dynamics. Here, we address a basic question of spike train formation: how do perithreshold synaptic inputs perturb the output of a spiking neuron? We recorded from single entorhinal principal cells in vitro and drove them to spike steadily at similar to 5 Hz (theta range) with direct current injection, then used a dynamic-clamp to superimpose strong excitatory conductance inputs at varying rates. Neurons spiked most reliably when the input rate matched the intrinsic neuronal firing rate. We also found a striking tendency of neurons to preserve their rates and coefficients of variation, independently of input rates. As mechanisms for this rate maintenance, we show that the efficacy of the conductance inputs varied with the relationship of input rate to neuronal firing rate, and with the arrival time of the input within the natural period. Using a novel method of spike classification, we developed a minimal Markov model that reproduced the measured statistics of the output spike trains and thus allowed us to identify and compare contributions to the rate maintenance and resonance. We suggest that the strength of rate maintenance may be used as a new categorization scheme for neuronal response and note that individual intrinsic spiking mechanisms may play a significant role in forming the rhythmic spike trains of activated neurons; in the entorhinal cortex, individual pacemakers may dominate production of the regional theta rhythm.

Original languageEnglish
Pages (from-to)1930-1939
Number of pages10
JournalEuropean Journal of Neuroscience
Volume32
Issue number11
Early online date29 Oct 2010
DOIs
Publication statusPublished - Dec 2010

Keywords

  • coding
  • entorhinal cortex
  • rat
  • reliability
  • resonance
  • spiking
  • theta
  • cat neocortical neurons
  • II stellate cells
  • layer-II
  • cortical-neurons
  • differential electroresponsivenss
  • ionic mechanisms
  • integration
  • dynamics
  • channels

Cite this

Rate maintenance and resonance in the entorhinal cortex. / Haas, Julie S.; Kreuz, Thomas; Torcini, Alessandro; Politi, Antonio; Abarbanel, H. D. I.

In: European Journal of Neuroscience, Vol. 32, No. 11, 12.2010, p. 1930-1939.

Research output: Contribution to journalArticle

Haas, Julie S. ; Kreuz, Thomas ; Torcini, Alessandro ; Politi, Antonio ; Abarbanel, H. D. I. / Rate maintenance and resonance in the entorhinal cortex. In: European Journal of Neuroscience. 2010 ; Vol. 32, No. 11. pp. 1930-1939.
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