Substitution reactions of 1,2-difluoro-4,5-dinitrobenzene were explored in dimethylformamide alone and with KOH/H2O, Hünig?s base or Et3N and with Me2NHCl/Et3N in EtOH. The fluorine atoms were always displaced in preference to the nitro groups. Three compounds were prepared from these studies and were characterised by X-ray single crystal structure determinations.
|Number of pages||8|
|Journal||Journal of Chemical Research|
|Early online date||20 Feb 2023|
|Publication status||Published - Feb 2023|
- Hofmann elimination
- Hünig’s base
- nucleophilic substitution