Real-life comparison of beclometasone dipropionate as an extrafine- or larger-particle formulation for asthma

David Price, Mike Thomas, John Haughney, Richard A Lewis, Anne Burden, Julie von Ziegenweidt, Alison Chisholm, Elizabeth V Hillyer, Christopher J Corrigan

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Abstract

BACKGROUND: Beclometasone dipropionate is an inhaled corticosteroid (ICS) available in both extrafine and larger-particle hydrofluoroalkane formulations. Extrafine beclometasone has greater small airway distribution and inhalation technique tolerance than larger-particle beclometasone; therefore, its use may be associated with improved asthma outcomes at population levels. The study objective was to compare real-life effectiveness of extrafine and larger-particle beclometasone.

METHODS: Retrospective matched cohort study including primary care patients with asthma (ages 12-60 and non-smokers 61-80 years) prescribed extrafine or larger-particle beclometasone by metered-dose inhaler. We studied patients receiving their first ICS (initiation population, n = 11,289) or switched from another ICS without dose change (switch population, n = 19,065). The extrafine and larger-particle beclometasone cohorts were matched in each population for demographic and database measures of asthma control during a baseline year; and endpoints assessed during 1 outcome year were adjusted for residual confounding factors.

RESULTS: The odds of no loss of asthma control (no asthma-related hospital attendance, consultation for lower respiratory tract infection, or oral corticosteroids) were significantly higher in the extrafine beclometasone cohorts of both initiation population (adjusted odds ratio [aOR] 1.12; 95% CI 1.02-1.23) and switch population (aOR 1.10; 95% CI 1.01-1.19). The odds of better adherence to ICS therapy were also significantly higher in both extrafine beclometasone cohorts (initiation population, aOR 1.64; 95% CI 1.52-1.75 and switch population, aOR 1.35; 95% CI 1.27-1.43).

CONCLUSIONS: These findings are consistent with the hypothesis that delivery of beclometasone in extrafine particle size produces real-life asthma treatment benefits. Clinical trials no. NCT01400217.

Original languageEnglish
Pages (from-to)987-1000
Number of pages14
JournalRespiratory Medicine
Volume107
Issue number7
Early online date3 May 2013
DOIs
Publication statusPublished - Jul 2013

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Keywords

  • Administration, Inhalation
  • Adolescent
  • Adult
  • Aged
  • Aged, 80 and over
  • Anti-Asthmatic Agents
  • Asthma
  • Beclomethasone
  • Chemistry, Pharmaceutical
  • Child
  • Drug Administration Schedule
  • Female
  • Glucocorticoids
  • Humans
  • Male
  • Medication Adherence
  • Metered Dose Inhalers
  • Middle Aged
  • Particle Size
  • Primary Health Care
  • Retrospective Studies
  • Treatment Outcome
  • Young Adult

Cite this

Price, D., Thomas, M., Haughney, J., Lewis, R. A., Burden, A., von Ziegenweidt, J., Chisholm, A., Hillyer, E. V., & Corrigan, C. J. (2013). Real-life comparison of beclometasone dipropionate as an extrafine- or larger-particle formulation for asthma. Respiratory Medicine, 107(7), 987-1000. https://doi.org/10.1016/j.rmed.2013.03.009