'Real world' pragmatic clinical trials: what are they and what do they tell us?

Peter Joseph Benedict Helms

Research output: Contribution to journalArticle

40 Citations (Scopus)

Abstract

Although the explanatory clinical therapeutic trial remains the foundation for assessing drug efficacy and is required for licensing purposes, the overall effectiveness of a treatment can be best judged by carefully designed and well conducted pragmatic 'real world' randomized trials. Pragmatic trials seek to inform prescribers and health care planners on the most effective and cost beneficial treatments. Pragmatic trials deserve more attention and should be included in evidence based guidelines for the pharmacological management of common diseases such as asthma and atopy.

Original languageEnglish
Pages (from-to)4-9
Number of pages5
JournalPediatric Allergy & Immunology
Volume13
Issue number1
DOIs
Publication statusPublished - 2002

Keywords

  • LABEL DRUG-USE
  • CHILDHOOD ASTHMA
  • BECLOMETHASONE DIPROPIONATE
  • INHALED CORTICOSTEROIDS
  • FLUTICASONE PROPIONATE
  • CHILDREN
  • BUDESONIDE
  • MEDICATION
  • EFFICACY
  • SAFETY

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