Fluoride binding by artificial receptors in water remains a challenging task due to the high hydration enthalpy of this anion. A novel cationic boron-based tripodal receptor featuring three flexible ammonium-containing arms has been prepared. NMR spectroscopy studies show that the receptor is capable of binding selectively the fluoride anion with high affinity in acidic water.
Trembleau, L., Smith, T. A. D., & Abdelrahman, M. H. (2013). Receptor conformational change induces fluoride binding despite competitive water binding. Chemical Communications, 49(52), 5850-5852. https://doi.org/10.1039/c3cc43019g