Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children

Jill King; Zoi-Dorothea  Pana; Thomas Lehrnbecher; Adilia Warris; William J.  Steinbach

doi:10.1093/jpids/pix053

Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children

Jill King, Zoi-Dorothea Pana, Thomas Lehrnbecher, Adilia Warris, William J. Steinbach

Applied Medicine

Research output: Contribution to journal › Article › peer-review

44 Citations (Scopus)

8 Downloads (Pure)

Abstract

Invasive fungal diseases (IFD) are devastating opportunistic infections that result in significant morbidity and mortality in a broad range of pediatric patients, particularly those with a compromised immune system. Recognition can be difficult, with non specific clinical signs and symptoms or isolated fever frequently the only presenting features. A high index of clinical suspicion in patients at increased risk of IFD is therefore necessary, and this requires knowledge of the pediatric patient population at risk, additional predisposing factors within this population, and the clinical signs and symptoms of IFD. This review aims to summarize our current knowledge regarding the recognition and clinical presentation of IFD in neonates and children.

Original language	English
Pages (from-to)	S12-S21
Number of pages	10
Journal	Journal of the Pediatric Infectious Diseases Society
Volume	6
Issue number	Suppl 1
Early online date	31 Aug 2017
DOIs	https://doi.org/10.1093/jpids/pix053
Publication status	Published - Sept 2017

Bibliographical note

AW and JK are supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen

Keywords

invasive fungal disease
clinical presentation
invasive aspergillosis
invasive candidiasis
pediatric patients

Access to Document

10.1093/jpids/pix053Licence: CC BY

Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children
© The Author 2017. Published by Oxford University Press on behalf of The Journal of the Pediatric Infectious Diseases Society. This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/4.0/), which permits unrestricted reuse, distribution, and reproduction in any medium, provided the original work is properly cited.
Final published version, 208 KBLicence: CC BY

Cite this

@article{56615e977bc04913a561e84312e637a8,

title = "Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children",

abstract = "Invasive fungal diseases (IFD) are devastating opportunistic infections that result in significant morbidity and mortality in a broad range of pediatric patients, particularly those with a compromised immune system. Recognition can be difficult, with non specific clinical signs and symptoms or isolated fever frequently the only presenting features. A high index of clinical suspicion in patients at increased risk of IFD is therefore necessary, and this requires knowledge of the pediatric patient population at risk, additional predisposing factors within this population, and the clinical signs and symptoms of IFD. This review aims to summarize our current knowledge regarding the recognition and clinical presentation of IFD in neonates and children. ",

keywords = "invasive fungal disease, clinical presentation, invasive aspergillosis, invasive candidiasis, pediatric patients",

author = "Jill King and Zoi-Dorothea Pana and Thomas Lehrnbecher and Adilia Warris and Steinbach, {William J.}",

note = "AW and JK are supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen",

year = "2017",

month = sep,

doi = "10.1093/jpids/pix053",

language = "English",

volume = "6",

pages = "S12--S21",

journal = "Journal of the Pediatric Infectious Diseases Society",

issn = "2048-7193",

publisher = "Oxford University Press",

number = "Suppl 1",

}

TY - JOUR

T1 - Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children

AU - King, Jill

AU - Pana, Zoi-Dorothea

AU - Lehrnbecher, Thomas

AU - Warris, Adilia

AU - Steinbach, William J.

N1 - AW and JK are supported by the Wellcome Trust Strategic Award (grant 097377) and the MRC Centre for Medical Mycology (grant MR/N006364/1) at the University of Aberdeen

PY - 2017/9

Y1 - 2017/9

N2 - Invasive fungal diseases (IFD) are devastating opportunistic infections that result in significant morbidity and mortality in a broad range of pediatric patients, particularly those with a compromised immune system. Recognition can be difficult, with non specific clinical signs and symptoms or isolated fever frequently the only presenting features. A high index of clinical suspicion in patients at increased risk of IFD is therefore necessary, and this requires knowledge of the pediatric patient population at risk, additional predisposing factors within this population, and the clinical signs and symptoms of IFD. This review aims to summarize our current knowledge regarding the recognition and clinical presentation of IFD in neonates and children.

AB - Invasive fungal diseases (IFD) are devastating opportunistic infections that result in significant morbidity and mortality in a broad range of pediatric patients, particularly those with a compromised immune system. Recognition can be difficult, with non specific clinical signs and symptoms or isolated fever frequently the only presenting features. A high index of clinical suspicion in patients at increased risk of IFD is therefore necessary, and this requires knowledge of the pediatric patient population at risk, additional predisposing factors within this population, and the clinical signs and symptoms of IFD. This review aims to summarize our current knowledge regarding the recognition and clinical presentation of IFD in neonates and children.

KW - invasive fungal disease

KW - clinical presentation

KW - invasive aspergillosis

KW - invasive candidiasis

KW - pediatric patients

U2 - 10.1093/jpids/pix053

DO - 10.1093/jpids/pix053

M3 - Article

SN - 2048-7193

VL - 6

SP - S12-S21

JO - Journal of the Pediatric Infectious Diseases Society

JF - Journal of the Pediatric Infectious Diseases Society

IS - Suppl 1

ER -

Recognition and Clinical Presentation of Invasive Fungal Disease in Neonates and Children

Abstract

Bibliographical note

Keywords

Access to Document

Fingerprint

Cite this