Recombinational repair and restart of damaged replication forks

Peter McGlynn; R. G. Lloyd

doi:10.1038/nrm951

Recombinational repair and restart of damaged replication forks

Peter McGlynn, R. G. Lloyd

Medical Sciences

Research output: Contribution to journal › Editorial › peer-review

362 Citations (Scopus)

Abstract

Genome duplication necessarily involves the replication of imperfect DNA templates and, if left to their own devices, replication complexes regularly run into problems. The details of how cells overcome these replicative 'hiccups' are beginning to emerge, revealing a complex interplay between DNA replication, recombination and repair that ensures faithful passage of the genetic material from one generation to the next.

Original language	English
Pages (from-to)	859-870
Number of pages	11
Journal	Nature Reviews. Molecular Cell Biology
Volume	3
Issue number	11
DOIs	https://doi.org/10.1038/nrm951
Publication status	Published - Nov 2002

Keywords

irradiated escherichia-coli
syndrome gene-product
strand break repair
synthetic holliday junctions
DNA-replication
saccharomyces-cerevisiae
lagging-strand
RNA-polymerase
in-vitro
transcription elongation

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10.1038/nrm951

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abstract = "Genome duplication necessarily involves the replication of imperfect DNA templates and, if left to their own devices, replication complexes regularly run into problems. The details of how cells overcome these replicative 'hiccups' are beginning to emerge, revealing a complex interplay between DNA replication, recombination and repair that ensures faithful passage of the genetic material from one generation to the next.",

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AU - Lloyd, R. G.

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AB - Genome duplication necessarily involves the replication of imperfect DNA templates and, if left to their own devices, replication complexes regularly run into problems. The details of how cells overcome these replicative 'hiccups' are beginning to emerge, revealing a complex interplay between DNA replication, recombination and repair that ensures faithful passage of the genetic material from one generation to the next.

KW - irradiated escherichia-coli

KW - syndrome gene-product

KW - strand break repair

KW - synthetic holliday junctions

KW - DNA-replication

KW - saccharomyces-cerevisiae

KW - lagging-strand

KW - RNA-polymerase

KW - in-vitro

KW - transcription elongation

U2 - 10.1038/nrm951

DO - 10.1038/nrm951

M3 - Editorial

VL - 3

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JO - Nature Reviews. Molecular Cell Biology

JF - Nature Reviews. Molecular Cell Biology

SN - 1471-0072

IS - 11

ER -

Recombinational repair and restart of damaged replication forks

Abstract

Keywords

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