Recombinational repair and restart of damaged replication forks

Peter McGlynn, R. G. Lloyd

Research output: Contribution to journalEditorial

341 Citations (Scopus)

Abstract

Genome duplication necessarily involves the replication of imperfect DNA templates and, if left to their own devices, replication complexes regularly run into problems. The details of how cells overcome these replicative 'hiccups' are beginning to emerge, revealing a complex interplay between DNA replication, recombination and repair that ensures faithful passage of the genetic material from one generation to the next.

Original languageEnglish
Pages (from-to)859-870
Number of pages11
JournalNature Reviews. Molecular Cell Biology
Volume3
Issue number11
DOIs
Publication statusPublished - Nov 2002

Keywords

  • irradiated escherichia-coli
  • syndrome gene-product
  • strand break repair
  • synthetic holliday junctions
  • DNA-replication
  • saccharomyces-cerevisiae
  • lagging-strand
  • RNA-polymerase
  • in-vitro
  • transcription elongation

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