Abstract
Objective: To examine the risk of recurrence of stillbirth in a second pregnancy.
Design: Retrospective cohort study.
Setting: Scotland, UK.
Population: All women who delivered their first and second pregnancies in Scotland between 1981 and 2005.
Methods: All women delivering for the first time between 1981 and 2000 were linked to records of their second pregnancy using routinely collected data from the Scottish Morbidity Returns. Women who had an intrauterine death in their first pregnancy formed the exposed cohort, whereas those who had a live birth formed the unexposed cohort.
Main outcome measure: Stillbirth in a second pregnancy.
Results: After adjusting for confounding factors, the odds of recurrence of stillbirth in a second pregnancy were found to be 1.94 (99% CI 1.29-2.92) compared with women who had had a live birth in their first pregnancy. Other factors associated with recurrence of stillbirth in a second pregnancy included placental abruption (adjusted OR 1.96; 99% CI 1.60-2.41), preterm delivery (adjusted OR 7.45; 99% CI 5.91-9.39) and low birthweight (adjusted OR 6.69; 99% CI 5.31-8.42). A Bayesian analysis using minimally informative normal priors found the risk of recurrence of stillbirth in a second pregnancy to be 1.59 (99% CI 1.10-2.33).
Conclusions: Women who have stillbirth in their first pregnancy have a higher risk of recurrence in their next pregnancy.
| Original language | English |
|---|---|
| Pages (from-to) | 1243-1247 |
| Number of pages | 5 |
| Journal | BJOG-An International Journal of Obstetrics and Gynaecology |
| Volume | 117 |
| Issue number | 10 |
| Early online date | 24 Jun 2010 |
| DOIs | |
| Publication status | Published - Sep 2010 |
Keywords
- Intrauterine death
- recurrence
- stillbirth
- prior fetal-death
- subsequent pregnancies
- cohort
- women
Cite this
Recurrence risk of stillbirth in a second pregnancy. / Bhattacharya, S.; Prescott, Gordon James; Black, Mairead Eileen; Shetty, A.
In: BJOG-An International Journal of Obstetrics and Gynaecology, Vol. 117, No. 10, 09.2010, p. 1243-1247.Research output: Contribution to journal › Article
}
TY - JOUR
T1 - Recurrence risk of stillbirth in a second pregnancy
AU - Bhattacharya, S.
AU - Prescott, Gordon James
AU - Black, Mairead Eileen
AU - Shetty, A.
PY - 2010/9
Y1 - 2010/9
N2 - Objective: To examine the risk of recurrence of stillbirth in a second pregnancy.Design: Retrospective cohort study.Setting: Scotland, UK.Population: All women who delivered their first and second pregnancies in Scotland between 1981 and 2005.Methods: All women delivering for the first time between 1981 and 2000 were linked to records of their second pregnancy using routinely collected data from the Scottish Morbidity Returns. Women who had an intrauterine death in their first pregnancy formed the exposed cohort, whereas those who had a live birth formed the unexposed cohort.Main outcome measure: Stillbirth in a second pregnancy.Results: After adjusting for confounding factors, the odds of recurrence of stillbirth in a second pregnancy were found to be 1.94 (99% CI 1.29-2.92) compared with women who had had a live birth in their first pregnancy. Other factors associated with recurrence of stillbirth in a second pregnancy included placental abruption (adjusted OR 1.96; 99% CI 1.60-2.41), preterm delivery (adjusted OR 7.45; 99% CI 5.91-9.39) and low birthweight (adjusted OR 6.69; 99% CI 5.31-8.42). A Bayesian analysis using minimally informative normal priors found the risk of recurrence of stillbirth in a second pregnancy to be 1.59 (99% CI 1.10-2.33).Conclusions: Women who have stillbirth in their first pregnancy have a higher risk of recurrence in their next pregnancy.
AB - Objective: To examine the risk of recurrence of stillbirth in a second pregnancy.Design: Retrospective cohort study.Setting: Scotland, UK.Population: All women who delivered their first and second pregnancies in Scotland between 1981 and 2005.Methods: All women delivering for the first time between 1981 and 2000 were linked to records of their second pregnancy using routinely collected data from the Scottish Morbidity Returns. Women who had an intrauterine death in their first pregnancy formed the exposed cohort, whereas those who had a live birth formed the unexposed cohort.Main outcome measure: Stillbirth in a second pregnancy.Results: After adjusting for confounding factors, the odds of recurrence of stillbirth in a second pregnancy were found to be 1.94 (99% CI 1.29-2.92) compared with women who had had a live birth in their first pregnancy. Other factors associated with recurrence of stillbirth in a second pregnancy included placental abruption (adjusted OR 1.96; 99% CI 1.60-2.41), preterm delivery (adjusted OR 7.45; 99% CI 5.91-9.39) and low birthweight (adjusted OR 6.69; 99% CI 5.31-8.42). A Bayesian analysis using minimally informative normal priors found the risk of recurrence of stillbirth in a second pregnancy to be 1.59 (99% CI 1.10-2.33).Conclusions: Women who have stillbirth in their first pregnancy have a higher risk of recurrence in their next pregnancy.
KW - Intrauterine death
KW - recurrence
KW - stillbirth
KW - prior fetal-death
KW - subsequent pregnancies
KW - cohort
KW - women
U2 - 10.1111/j.1471-0528.2010.02641.x
DO - 10.1111/j.1471-0528.2010.02641.x
M3 - Article
VL - 117
SP - 1243
EP - 1247
JO - BJOG-An International Journal of Obstetrics and Gynaecology
JF - BJOG-An International Journal of Obstetrics and Gynaecology
SN - 1470-0328
IS - 10
ER -