Recurrence risk of unexplained stillbirth: A systematic review and meta-analysis

KA Lamont, S Bhattacharya, GT Jones, NW Scott

Research output: Contribution to journalAbstractpeer-review

Abstract

Background Stillbirth remains a significant problem worldwide. Unexplained stillbirth is the most common classification of cause of death accounting for between 10–70%. Studies that investigate recurrence risk of unexplained stillbirth yield inconsistent results.

Objective To investigate the association between unexplained stillbirth in a first pregnancy and recurrence risk of stillbirth in a subsequent pregnancy in high-income countries.

Methods Six databases were searched using a comprehensive search strategy to identify relevant cohort and case-control studies. No publication status, language or date restrictions were applied. Internet resources and reference lists of relevant papers were also searched. Using explicit a priori criteria two reviewers independently screened titles to identify eligible studies, extract data and assess methodological quality. Random-effects meta-analyses were used to combine results of included studies.

Results Seventeen studies were included in the systematic review fifteen of which were considered eligible for the meta-analysis. Stillbirth and unexplained stillbirth in a first pregnancy was associated with an increased risk of stillbirth in a subsequent pregnancy. Compared with women who had a live birth in a first pregnancy the pooled crude and adjusted odds ratios (OR) and 95% confidence intervals (CI) of stillbirth recurrence for women with a previous stillbirth were 4.75(3.74, 6.03) and 2.34(1.53, 3.57) respectively. Compared with women who had a live birth in a first pregnancy the pooled adjusted OR of stillbirth recurrence for women with a previous unexplained stillbirth was 1.83(1.38, 2.44)

Conclusion This systematic review and meta-analysis provides some evidence to support an increased recurrence risk for unexplained stillbirth.
Original languageEnglish
Pages (from-to)A153
JournalArchives of Disease in Childhood. Fetal and Neonatal Edition
Volume99
Issue numberSuppl. 1
DOIs
Publication statusPublished - 2014

Bibliographical note

Poster

Fingerprint

Dive into the research topics of 'Recurrence risk of unexplained stillbirth: A systematic review and meta-analysis'. Together they form a unique fingerprint.

Cite this