Reduced lung function both before bronchiolitis and at 11 years

Stephen William Turner, S. Young, L. I. Landau, P. N. Le Souef

Research output: Contribution to journalArticle

75 Citations (Scopus)

Abstract

Background and Aims: We have previously shown an association between reduced premorbid lung function (V'maxFRC) and bronchiolitis. We hypothesised that individuals with bronchiolitis will go on to have reduced lung function and increased respiratory symptoms in childhood.

Methods: V'maxFRC was measured at 1 month of age; individuals with bronchiolitis were prospectively identified. Annual symptom questionnaires were completed from 3 to 6 years. At 11 years of age, children underwent an assessment including questionnaire, lung function, airway response to histamine (AR), and skin prick testing.

Results: Eighteen individuals with bronchiolitis were ascertained from 253 cohort members. Children with bronchiolitis had increased viral induced wheeze at 3 (OR 5.8, 95% CI 1.4 to 25.2; n=103) and 5 years (OR 5.3, 95% CI 1.1 to 25.5; n=101). At 11 years of age, 194 children were assessed including 16 with past bronchiolitis. These 16 individuals had reduced mean z scores for % V'maxFRC compared with other children (-0.56 and 0.06 respectively) and mean z scores for % FEF25-75 at 11 years (-0.53 and 0.06 respectively). At 11 years, FEV1, FVC PEF, AR, atopy, wheeze, and diagnosed asthma were not different between groups.

Conclusions: Reduced lung function is present before and after bronchiolitis; the level of reduction is comparable. The mechanism for wheeze and reduced lung function after bronchiolitis appears to be related to premorbid lung function and not bronchiolitis per se.

Original languageEnglish
Pages (from-to)417-420
Number of pages3
JournalArchives of Disease in Childhood
Volume87
Issue number5
DOIs
Publication statusPublished - 2002

Keywords

  • RESPIRATORY SYNCYTIAL VIRUS
  • BRONCHIAL HYPERRESPONSIVENESS
  • ASTHMA
  • INFANTS
  • ALLERGY
  • LIFE
  • RESPONSIVENESS
  • INFECTION
  • CHILDREN
  • RISK

Cite this

Reduced lung function both before bronchiolitis and at 11 years. / Turner, Stephen William; Young, S.; Landau, L. I.; Le Souef, P. N.

In: Archives of Disease in Childhood, Vol. 87, No. 5, 2002, p. 417-420.

Research output: Contribution to journalArticle

Turner, Stephen William ; Young, S. ; Landau, L. I. ; Le Souef, P. N. / Reduced lung function both before bronchiolitis and at 11 years. In: Archives of Disease in Childhood. 2002 ; Vol. 87, No. 5. pp. 417-420.
@article{a525da67dd6340ac9efe60f3ef687a7a,
title = "Reduced lung function both before bronchiolitis and at 11 years",
abstract = "Background and Aims: We have previously shown an association between reduced premorbid lung function (V'maxFRC) and bronchiolitis. We hypothesised that individuals with bronchiolitis will go on to have reduced lung function and increased respiratory symptoms in childhood.Methods: V'maxFRC was measured at 1 month of age; individuals with bronchiolitis were prospectively identified. Annual symptom questionnaires were completed from 3 to 6 years. At 11 years of age, children underwent an assessment including questionnaire, lung function, airway response to histamine (AR), and skin prick testing.Results: Eighteen individuals with bronchiolitis were ascertained from 253 cohort members. Children with bronchiolitis had increased viral induced wheeze at 3 (OR 5.8, 95{\%} CI 1.4 to 25.2; n=103) and 5 years (OR 5.3, 95{\%} CI 1.1 to 25.5; n=101). At 11 years of age, 194 children were assessed including 16 with past bronchiolitis. These 16 individuals had reduced mean z scores for {\%} V'maxFRC compared with other children (-0.56 and 0.06 respectively) and mean z scores for {\%} FEF25-75 at 11 years (-0.53 and 0.06 respectively). At 11 years, FEV1, FVC PEF, AR, atopy, wheeze, and diagnosed asthma were not different between groups.Conclusions: Reduced lung function is present before and after bronchiolitis; the level of reduction is comparable. The mechanism for wheeze and reduced lung function after bronchiolitis appears to be related to premorbid lung function and not bronchiolitis per se.",
keywords = "RESPIRATORY SYNCYTIAL VIRUS, BRONCHIAL HYPERRESPONSIVENESS, ASTHMA, INFANTS, ALLERGY, LIFE, RESPONSIVENESS, INFECTION, CHILDREN, RISK",
author = "Turner, {Stephen William} and S. Young and Landau, {L. I.} and {Le Souef}, {P. N.}",
year = "2002",
doi = "10.1136/adc.87.5.417",
language = "English",
volume = "87",
pages = "417--420",
journal = "Archives of Disease in Childhood",
issn = "0003-9888",
publisher = "BMJ Publishing Group",
number = "5",

}

TY - JOUR

T1 - Reduced lung function both before bronchiolitis and at 11 years

AU - Turner, Stephen William

AU - Young, S.

AU - Landau, L. I.

AU - Le Souef, P. N.

PY - 2002

Y1 - 2002

N2 - Background and Aims: We have previously shown an association between reduced premorbid lung function (V'maxFRC) and bronchiolitis. We hypothesised that individuals with bronchiolitis will go on to have reduced lung function and increased respiratory symptoms in childhood.Methods: V'maxFRC was measured at 1 month of age; individuals with bronchiolitis were prospectively identified. Annual symptom questionnaires were completed from 3 to 6 years. At 11 years of age, children underwent an assessment including questionnaire, lung function, airway response to histamine (AR), and skin prick testing.Results: Eighteen individuals with bronchiolitis were ascertained from 253 cohort members. Children with bronchiolitis had increased viral induced wheeze at 3 (OR 5.8, 95% CI 1.4 to 25.2; n=103) and 5 years (OR 5.3, 95% CI 1.1 to 25.5; n=101). At 11 years of age, 194 children were assessed including 16 with past bronchiolitis. These 16 individuals had reduced mean z scores for % V'maxFRC compared with other children (-0.56 and 0.06 respectively) and mean z scores for % FEF25-75 at 11 years (-0.53 and 0.06 respectively). At 11 years, FEV1, FVC PEF, AR, atopy, wheeze, and diagnosed asthma were not different between groups.Conclusions: Reduced lung function is present before and after bronchiolitis; the level of reduction is comparable. The mechanism for wheeze and reduced lung function after bronchiolitis appears to be related to premorbid lung function and not bronchiolitis per se.

AB - Background and Aims: We have previously shown an association between reduced premorbid lung function (V'maxFRC) and bronchiolitis. We hypothesised that individuals with bronchiolitis will go on to have reduced lung function and increased respiratory symptoms in childhood.Methods: V'maxFRC was measured at 1 month of age; individuals with bronchiolitis were prospectively identified. Annual symptom questionnaires were completed from 3 to 6 years. At 11 years of age, children underwent an assessment including questionnaire, lung function, airway response to histamine (AR), and skin prick testing.Results: Eighteen individuals with bronchiolitis were ascertained from 253 cohort members. Children with bronchiolitis had increased viral induced wheeze at 3 (OR 5.8, 95% CI 1.4 to 25.2; n=103) and 5 years (OR 5.3, 95% CI 1.1 to 25.5; n=101). At 11 years of age, 194 children were assessed including 16 with past bronchiolitis. These 16 individuals had reduced mean z scores for % V'maxFRC compared with other children (-0.56 and 0.06 respectively) and mean z scores for % FEF25-75 at 11 years (-0.53 and 0.06 respectively). At 11 years, FEV1, FVC PEF, AR, atopy, wheeze, and diagnosed asthma were not different between groups.Conclusions: Reduced lung function is present before and after bronchiolitis; the level of reduction is comparable. The mechanism for wheeze and reduced lung function after bronchiolitis appears to be related to premorbid lung function and not bronchiolitis per se.

KW - RESPIRATORY SYNCYTIAL VIRUS

KW - BRONCHIAL HYPERRESPONSIVENESS

KW - ASTHMA

KW - INFANTS

KW - ALLERGY

KW - LIFE

KW - RESPONSIVENESS

KW - INFECTION

KW - CHILDREN

KW - RISK

U2 - 10.1136/adc.87.5.417

DO - 10.1136/adc.87.5.417

M3 - Article

VL - 87

SP - 417

EP - 420

JO - Archives of Disease in Childhood

JF - Archives of Disease in Childhood

SN - 0003-9888

IS - 5

ER -