Reducing mucus production after urinary reconstruction: A prospective randomised trial.

James Michael Olu N'Dow, C. N. Robson, J. N. S. Matthews, D. E. Neal, J. P. Pearson

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29 Citations (Scopus)

Abstract

Purpose: After transposition into the urinary tract, intestinal segments continue to produce mucus. We determine the effectiveness of muco-regulatory drugs, including N-acetylcysteine, aspirin and ranitidine, in reducing mucus secretion and urine viscosity in patients with transposed segments.

Materials and Methods: Our trial was a prospective randomized, double-blind placebo controlled crossover study involving 12 patients who underwent ileal conduit and 31 who underwent bladder reconstruction, Each treatment lasted 3 weeks with a a-week washout. Pretreatment and posttreatment 24-hour urine samples were analyzed for mucin and viscosity after papain digestion, sodium dodecyl sulfate-polyacrylamide gel electrophoresis and periodic acid-Schiff assay. A disease specific questionnaire and SF-36 quality of life survey were completed.

Results: According to the questionnaire, mucus production did not decrease with time in 67% of patients. Mucin comprised 3% of the total nondialyzable material in urine (65 mg./24-hour for ileal conduit and 60 mg,/24-hour for bladder reconstruction). Analysis of questionnaires and laboratory results failed to demonstrate any benefit of taking muco-regulatory agents compared with placebo.

Conclusions: The use of N-acetylcysteine, aspirin and ranitidine did not result in a reduction in mucin production, urine viscosity or improvement in quality of life.

Original languageEnglish
Pages (from-to)1433-1440
Number of pages7
JournalJournal of Urology
Volume165
Issue number5
DOIs
Publication statusPublished - 2001

Keywords

  • mucus
  • expectorants
  • acetylcysteine
  • aspirin
  • ranitidine
  • HUMAN GALL-BLADDER
  • TRACT RECONSTRUCTION
  • ILEAL NEOBLADDER
  • ACETYLCYSTEINE
  • GLYCOPROTEIN
  • MUCIN
  • ENTEROCYSTOPLASTY
  • AUGMENTATION
  • DISSOLUTION
  • CYSTOPLASTY

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